Appendix 1. MEDLINE search strategy

MEDLINE (Ovid version) search strategy
1 randomised controlled trial. pt.
2 controlled clinical trial. pt.
3 randomised controlled trials/
4 random allocation/
5 double blind method/
6 single‐blind method/
7 or/1‐6
8 animal/ not human/
9 7 not 8
10 clinical trial. pt.
11 Exp clinical trials/
12 (clin$ adj25 trial$).ti,ab.
13 ((singl$ or doubl$ or treb$) adj25 (blind$ or mask$)).ti,ab.
14 placebos/
15 placebo$.ti,ab.
16 random$.ti,ab.
17 research design/
18 or/10‐17
19 18 not 8
20 19 not 9
21 comparative study/
22 exp evaluation studies/
23 follow up studies/
24 prospective studies/
25 (control$ or prospectiv$ or volunteer$).ti,ab.
26 or/21‐25
27 26 not 8
28 27 not (9 or 20)
29 9 or 20 or 28
30. exp Hydroxymethylglutaryl‐CoA Reductase Inhibitors/
31. "hydroxymethylglutaryl‐CoA reductase inhibitor$".tw.
32. "HMG CoA reductase inhibitor$".tw.
33. "HMG Co A reductase inhibitor$".tw.
34. statin$.tw. "17. fluvastatin.tw.
35. simvastatin.tw.
36. pravastatin.tw.
37. lovastatin.tw.
38.rosuvastatin. tw.
39. fluvastatin. tw.
40. cerivastatin.tw.
41. atorvastatin.tw.
42. or/30‐41
43. hypertension/
44. hypertension. tw.
45. 43 or 44
46. 29 and 42 and 45