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Forest plot of comparison: 3 Paracetamol 500 mg versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 4 to 6 hours.
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Figure 1

Forest plot of comparison: 3 Paracetamol 500 mg versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 4 to 6 hours.

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Forest plot of comparison: 4 Paracetamol 600‐650 mg versus placebo, outcome: 4.1 Participants with at least 50% pain relief over 4 to 6 hours.
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Figure 2

Forest plot of comparison: 4 Paracetamol 600‐650 mg versus placebo, outcome: 4.1 Participants with at least 50% pain relief over 4 to 6 hours.

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Forest plot of comparison: 5 Paracetamol 975‐1000 mg versus placebo, outcome: 5.1 Participants with at least 50% pain relief over 4 to 6 hours.
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Figure 3

Forest plot of comparison: 5 Paracetamol 975‐1000 mg versus placebo, outcome: 5.1 Participants with at least 50% pain relief over 4 to 6 hours.

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Forest plot of comparison: 3 Paracetamol 500 mg versus placebo, outcome: 3.4 Participants using rescue medication over 4 to 6 hours.
Figuras y tablas -
Figure 4

Forest plot of comparison: 3 Paracetamol 500 mg versus placebo, outcome: 3.4 Participants using rescue medication over 4 to 6 hours.

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Forest plot of comparison: 4 Paracetamol 600‐650 mg versus placebo, outcome: 4.4 Participants using rescue medication over 4 to 6 hours.
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Figure 5

Forest plot of comparison: 4 Paracetamol 600‐650 mg versus placebo, outcome: 4.4 Participants using rescue medication over 4 to 6 hours.

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Forest plot of comparison: 5 Paracetamol 975‐1000 mg versus placebo, outcome: 5.4 Participants using rescue medication over 4 to 6 hours.
Figuras y tablas -
Figure 6

Forest plot of comparison: 5 Paracetamol 975‐1000 mg versus placebo, outcome: 5.4 Participants using rescue medication over 4 to 6 hours.

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Forest plot of comparison: 1 Paracetamol all doses versus placebo, outcome: 1.3 Participants with any adverse event.
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Figure 7

Forest plot of comparison: 1 Paracetamol all doses versus placebo, outcome: 1.3 Participants with any adverse event.

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Forest plot of comparison: 3 Paracetamol 500 mg versus placebo, outcome: 3.5 Participants with any adverse event.
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Figure 8

Forest plot of comparison: 3 Paracetamol 500 mg versus placebo, outcome: 3.5 Participants with any adverse event.

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Forest plot of comparison: 4 Paracetamol 600‐650 mg versus placebo, outcome: 4.5 Participants with any adverse event.
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Figure 9

Forest plot of comparison: 4 Paracetamol 600‐650 mg versus placebo, outcome: 4.5 Participants with any adverse event.

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Forest plot of comparison: 5 Paracetamol 975‐1000 mg versus placebo, outcome: 5.5 Participants with any adverse event.
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Figure 10

Forest plot of comparison: 5 Paracetamol 975‐1000 mg versus placebo, outcome: 5.5 Participants with any adverse event.

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Comparison 1 Paracetamol all doses versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 1.1

Comparison 1 Paracetamol all doses versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 1 Paracetamol all doses versus placebo, Outcome 2 Participants using rescue medication over 4 to 6 hours.
Figuras y tablas -
Analysis 1.2

Comparison 1 Paracetamol all doses versus placebo, Outcome 2 Participants using rescue medication over 4 to 6 hours.

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Comparison 1 Paracetamol all doses versus placebo, Outcome 3 Participants with any adverse event.
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Analysis 1.3

Comparison 1 Paracetamol all doses versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 1 Paracetamol all doses versus placebo, Outcome 4 Participants with any adverse event, dental.
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Analysis 1.4

Comparison 1 Paracetamol all doses versus placebo, Outcome 4 Participants with any adverse event, dental.

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Comparison 1 Paracetamol all doses versus placebo, Outcome 5 Participants with any adverse event, surgical.
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Analysis 1.5

Comparison 1 Paracetamol all doses versus placebo, Outcome 5 Participants with any adverse event, surgical.

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Comparison 2 Paracetamol 325 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 2.1

Comparison 2 Paracetamol 325 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 3 Paracetamol 500 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 3.1

Comparison 3 Paracetamol 500 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 3 Paracetamol 500 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours, dental.
Figuras y tablas -
Analysis 3.2

Comparison 3 Paracetamol 500 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours, dental.

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Comparison 3 Paracetamol 500 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, surgical.
Figuras y tablas -
Analysis 3.3

Comparison 3 Paracetamol 500 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, surgical.

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Comparison 3 Paracetamol 500 mg versus placebo, Outcome 4 Participants using rescue medication over 4 to 6 hours.
Figuras y tablas -
Analysis 3.4

Comparison 3 Paracetamol 500 mg versus placebo, Outcome 4 Participants using rescue medication over 4 to 6 hours.

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Comparison 3 Paracetamol 500 mg versus placebo, Outcome 5 Participants with any adverse event.
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Analysis 3.5

Comparison 3 Paracetamol 500 mg versus placebo, Outcome 5 Participants with any adverse event.

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Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
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Analysis 4.1

Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours, dental.
Figuras y tablas -
Analysis 4.2

Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours, dental.

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Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, surgical.
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Analysis 4.3

Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, surgical.

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Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 4 Participants using rescue medication over 4 to 6 hours.
Figuras y tablas -
Analysis 4.4

Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 4 Participants using rescue medication over 4 to 6 hours.

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Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 5 Participants with any adverse event.
Figuras y tablas -
Analysis 4.5

Comparison 4 Paracetamol 600‐650 mg versus placebo, Outcome 5 Participants with any adverse event.

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Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 5.1

Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours, dental.
Figuras y tablas -
Analysis 5.2

Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours, dental.

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Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, surgical.
Figuras y tablas -
Analysis 5.3

Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, surgical.

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Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 4 Participants using rescue medication over 4 to 6 hours.
Figuras y tablas -
Analysis 5.4

Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 4 Participants using rescue medication over 4 to 6 hours.

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Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 5 Participants with any adverse event.
Figuras y tablas -
Analysis 5.5

Comparison 5 Paracetamol 975‐1000 mg versus placebo, Outcome 5 Participants with any adverse event.

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Comparison 6 Paracetamol 1500 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 6.1

Comparison 6 Paracetamol 1500 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 1 Quality score of 3 or more.
Figuras y tablas -
Analysis 7.1

Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 1 Quality score of 3 or more.

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Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 2 Quality of 2.
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Analysis 7.2

Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 2 Quality of 2.

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Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 3 More than 40 patients in each arm, 975/1000mg paracetamol vs placebo, quality score of three of more, dental.
Figuras y tablas -
Analysis 7.3

Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 3 More than 40 patients in each arm, 975/1000mg paracetamol vs placebo, quality score of three of more, dental.

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Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 4 Less than 40 patients in each arm, 975/1000mg paracetamol vs placebo, quality score of three of more, dental.
Figuras y tablas -
Analysis 7.4

Comparison 7 Paracetamol versus placebo, sensitivity analysis, Outcome 4 Less than 40 patients in each arm, 975/1000mg paracetamol vs placebo, quality score of three of more, dental.

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Table 1. Summary of Outcomes: analgesia and use of rescue medication

Analgesia

Rescue medication

Study ID

Treatment

PI or PR

Number with 50% PR

PGE: very good or excellent

Time to use (hr)

% using

Bentley 1987

(1) Paracetamol 1000 mg, n=41

(2) Paracetamol+codeine 1000/60 mg, n=41

(3) Codeine 60 mg, n=21

(4) Placebo, n=17

TOTPAR 5:

(1) 8.7

(4) 4.9

(1) 19/41

(4) 4/17

No data

Median:

(1) 3.3

(4) 1.4

at 4 hrs:

(1) 68

(4) 81

Berry 1975

(1) Paracetamol 1000 mg, n=76

(2) Propoxyphene, 65 mg, n=73

(3) Placebo, n=76

non standard scales

(1) 63/76

(3) 18/76

Global rating > good:

(1) 63/76

(3) 18/76

No data

at 4 hrs:

(1) 2

(3) 17

Bhounsule 1990

(1) Paracetamol 1000 mg, n=20

(2) Ibuprofen 400 mg, n=20

(3) Aspirin 600 mg, n=20

(4) Analgin 500 mg, n=20

(5) Placebo, n=20

SPID 6:

(1) 5.4

(5) 4.4

(1) 7/20

(5) 6/20

No data

No data

No data

Bjune 1996

(1) Paracetamol 1000 mg, n=50

(2) Paracetamol+codeine 800/60 mg, n=50

(3) Placebo, n=25

TOTPAR 6:

severe pain

(1) 6.4

(3) 0

moderate pain

(1) 8.0

(3) 1.5

(1) 12/43

(3) 0/21

No data

No data

No data

Cooper 1980

(1) Paracetamol 500 mg, n=37

(2) Oxycodone 5 mg, n=42

(3) Paracetamol+oxycodone 500/5 mg, n=45

(4) Paracetamol+oxycodone 1000/5 mg, n=40

(5) Paracetamol+oxycodone 1000/10 mg, n=45

(6) Placebo, n=38

TOTPAR 4:

(1) 5.1

(6) 4.8

(1) 11/37

(6) 11/38

No data

Mean:

(1) 2.8

(6) 2.5

No data

Cooper 1981

(1) Paracetamol 650 mg, n=37

(2) Paracetamol+codeine 650/60 mg, n=42

(3) Paracetamol+d‐propoxyphene 650/100 mg, n=42

(4) Ibuprofen 200 mg, n=42

(5) Placebo, n=37

TOTPAR 4:

(1) 8.2

(3) 3.4

(1) 21/37

(5) 6/37

No usable data

Mean:

(1) 3.5

(5) 2.9

at 4 hrs:

(1) 5

(5) 54

Cooper 1986

(1) Paracetamol 1000 mg, n=38

(2) Paracetamol+codeine+caffeine 1000/16/30 mg, n=39

(3) Placebo, n=22

TOTPAR 6:

(1) 11.6

(3) 4.3

(1) 20/38

(3) 3/22

No data

Mean:

(1) 4.7

(3) 3.5

No data

Cooper 1988

(1) Paracetamol 600 mg, n=36

(2) Paracetamol+codeine 600+60 mg, n=31

(3) Placebo, n=40

TOTPAR 6:

(1) 8.0

(3) 6.3

(1) 12/36

(3) 9/40

(1) 12/36

(3) 8/40

No data

at 6 hrs:

(1) 78

(3) 82

Cooper 1989

(1) Paracetamol 1000 mg, n=59

(2) Ibuprofen 400 mg, n=61

(3) Placebo, n=64

TOTPAR 6:

(1) 10.2

(3) 4.7

(1) 27/59

(3) 9/64

(1) 16/59

(3) 4/64

Median:

(1) 3.7

(3) 2.3

Mean:

(1) 4.1

(3) 3.3

at 6 hrs:

(1) 63

(3) 78

Cooper 1991

(1) Paracetamol 650 mg, n=37

(2) Paracetamol+codeine 650/60 mg, n=39

(3) Zomepirac 100 mg, n=23

(4) Flurbiprofen 50 mg, n=42

(5) Flurbiprofen 100 mg, n=41

(6) Placebo, n=44

TOTPAR 6:

(1) 6.8

(6) 5.7

(1) 10/37

(6) 9/44

(1) 3/37

(6) 2/44

Mean:

(1) 3.2

(6) 3.1

at 6 hrs:

(1) 95

(6) 84

Cooper 1998

(1) Paracetamol 1000 mg n=50

(2) Ketoprofen 100 mg, n=51

(3) Ketoprofen 1000 mg, n=50

(4) Placebo, n=26

TOTPAR 6:

(1) 8.2

(4) 4.5

(1) 17/50

(4) 3/26

No data

median:

(1) 3.3

(4) 1.7

at 6 hrs:

(1) 60

(4) 78

Dionne 1994

(1) Paracetamol 650 mg, n=27

(2) Paracetamol+codeine 650/60 mg, n=24

(3) Flurbiprofen 50 mg, n=25

(4) Flurbiprofen 100 mg, n=22

(5) Placebo, n=25

TOTPAR 6:

(1) 18.4

(5) 14.9

(1) 24/27

(5) 18/25

No usable data

no data

no data

Dolci 1994

(1) Paracetamol 500 mg, n=72

(2) Piroxicam 20 mg, n=76

(3) Piroxicam cyclodextrin =20 mg, n=74

(4) Placebo, n=76

TOTPAR 4:

(1) 10.5

(6) 5.4

(1) 54/72

(4) 25/76

No usable data

no data

at 4 hrs:

(1) 15/72

(4) 46/76

Edwards 2002

(1) Paracetamol 650 mg, n=340

(2) Placebo, n=339

5 dental studies included in meta‐analysis

TOTPAR 6:

values not given

(1) 108/340

(2) 14/339

(1) 110/340

(2) 34/337

No data

1) 9

2) 36

Edwards 2002

(1) Paracetamol 975 mg, n=100

(2) Placebo, n=100

2 gynae or ortho studies in meta‐analysis

TOTPAR 6:

values not given

(1) 45/100

(2) 25/100

(1) 37/100

(2) 22/100

No data

1) 3

2) 1

Fassolt 1983

(1) Paracetamol 650 mg, n=29

(2) Suprofen 200 mg, n=32

(3) Suprofen 400 mg, n=28

(4) Paracetamol+suprofen 650/100 mg, n=29

(5) Placebo, n=28

TOTPAR 6:

(1) 15.1

(5) 7.5

(1) 21/29

(5) 8/28

(1) 21/29

(5) 5/27

No data

at 6 hrs:

(1) 4/29

(5) 19/28

Forbes 1982

(1) Paracetamol 600 mg, n=34

(2) Paracetamol+codeine 600/60 mg, n=31

(3) Diflusinal 500 mg, n=32

(4) Diflusinal 1000 mg, n=32

(5) Placebo, n=30

TOTPAR 4:

(1) 8.9

(5) 3.8

(1) 15/34

(5) 6/30

No usable data

Median:

(1) 3.5

(5) 2.4

at 6 hrs:

(1) 70

(5) 82

Forbes 1983

(1) Paracetamol 600 mg, n=26

(2) Paracetamol+codeine 600/60 mg, n=26

(3) Diflusinal 500 mg, n=26

(4) Diflusinal 1000 mg, n=28

(5) Placebo, n=26

TOTPAR 6:

(1) 11.2

(5) 5.4

(1) 13/26

(5) 5/26

No usable data

Median:

(1) 4.0

(5) 1.9

at 6 hrs:

(1) 73

(5) 86

Forbes 1984a

(1) Paracetamol 650 mg, n=39

(2) Phenyltoloxamine 60 mg, n=33

(3) Patacetamol+phenyltoxolamine 650/60 mg, n=40

(4) Placebo, n=36

TOTPAR 6:

(1) 6.7

(4) 2.1

(1) 10/39

(4) 0/36

No usable data

Mean:

(1) 4.3

(4) 2.7

at 6 hrs:

(1) 74

(4) 97

Forbes 1984b

(1) Paracetamol 650 mg, n=31

(2) Nalbuphine 30 mg, n=32

(3) Paracetamol+nalbuphine 650/30 mg, n=33

(4) Placebo, n=33

TOTPAR 6:

(1) 8.5

(4) 4.5

(1) 11/31

(4) 4/33

No usable data

No data

No data

Forbes 1989

(1) Paracetamol 600 mg, n=22

(2) Paracetamol+codeine 600/60 mg, n=17

(3) Flurbiprofen 100 mg, n=26

(4) Placebo, n=23

(1) 4.6

(4) 2.0

(1) 1/22

(4) 0/23

No usable data

Median:

(1) 2.8

(4) 1.7

at 4 hrs:

(1) 82

(4) 91

Forbes 1990

(1) Paracetamol 600 mg, n=36

(2) Paracetamol+codeine 600/60 mg, n=38

(3) Ketorolac 10 mg, n=31

(4) Ketorolac 20 mg, n=35

(5) Ibuprofen 400 mg, n=32

(6) Placebo, n=34

TOTPAR 6:

(1) 5.8

(6) 1.9

(1) 7/3

(6) 0/34

No usable data

Median:

(1) 3.0

(6) 1.8

Mean:

(1) 3.9

(6) 2.9

at 6 hrs:

(1) 81

(6) 97

Haglund 2006

(1) Paracetamol 1000 mg, n=20

(2) Rofecoxib+paracetamol 50/1000 mg, n=34

(3) Rofecoxib 50 mg, n=36

(4) Placebo n=17

TOTPAR 6:

(1) 11.5

(4) 0.25

(1) 10/20

(4) 0/17

No usable data

Median:

(1) >8

(4) 1.5

At 8 hrs:

(1) 40.0

(4) 71

At 6 hrs:

(1) 24

(4) 70

Hersch 2000

(1) Paracetamol capsule 1000 mg, n=63

(2) Ibuprofen liquigel 200 mg, n=61

(3) Ibuprofen liquigel, 400 mg n=59

(4) Placebo, n=27

TOTPAR 6:

(1) 11.99

(4) 5.25

at 6 hrs:

(1) 52%

(4) 14%

Median:

(1) 6

(4) 1.63

at 6 hrs:

(1) 50

(4) 75

Honig 1984

(1) Paracetamol 600 mg, n = 28

(2) Paracetamol+codeine 600/60 mg, n=28

(3) Codeine 60 mg, n=28

(4) Placebo, n = 25

TOTPAR 6:

(1) value not given

(4) 8.9

(1) 11/28

(4) 6/30

at 6 hrs:

(1) 8/28

(4) 4/25

No data

at 6 hrs:

(1) 16/28

(4) 114/30

Jain 1986

(1) Paracetamol 650 mg, n=30

(2) Nalbuphine 30 mg, n=34

(3) Paracetamol+nalbuphine 650/30 mg, n=32

(4) Placebo, n=32

TOTPAR 6:

(1) 10.4

(4) 7.9

(1) 13/29

(4) 10/30

No data

No data

at 6 hrs:

(1) 10/30

(4) 11/32

Kiersch 1994

(1) Paracetamol 1000 mg, n=92

(2) Naproxen Na 440 mg, n=89

(3) Placebo, n=45

TOTPAR 6:

(1) 6.2

(3) 3.1

(1) 21/92

(3) 3/45

No usable data

Median:

(1) 3.1

(3) 2.0

at 6 hrs:

(1) 69

(3) 85

Kubitzek 2003

(1) Paracetamol 1000 mg, n=78

(2) Diclofenac K 25 mg, n=83

(3) Placebo, n=84

TOTPAR 6:

values not given

At 6 hrs:

(1) 45/78

(3) 7/84

at 6 hrs:

(1) 17/78

(3) 1/84

Median:

(1) 4.2

(3) 1.5

at 6h:

(1) 76

(3) 89

Laska 1983 (Study 3)

(1) Paracetamol 500 mg, n=81

(2) Paracetamol 1000 mg, n=81

(3) Paracetamol 1500 mg, n=81

(4) Placebo, n=57

%max SPID:

(1) 43

(2) 46.4

(3) 49.8

(4) 29.9

(1) 46/81

(2) 49/81

(3) 53/81

(4) 22/57

No data

not estimable

at 4 hrs:

None

Lenhert 1990

(1) Paracetamol 1000 mg, n=49

(2) Aspirin 1000 mg, n=45

(3) Placebo, n=40

SPID 6:

(1) 5.8

(3) 1.5

(1) 24/49

(3) 5/40

No usable data

No data

No data

McQuay 1988

(1) Paracetamol 1000 mg, n=30

(2) Bromfenac 5 mg, n=30

(3) Bromfenac 10 mg, n=30

(4) Bromfenac 25 mg, n=30

(5) Placebo, n=30

TOTPAR 6:

(1) 7.9

(5) 4.1

(1) 10/30

(5) 3/30

No usable data

Median:

(1) 3.7

(5) 3.0

at 6 hrs:

(1) 63

(5) 87

Mehlisch 1984

(1) Paracetamol 1000 mg, n=58

(2) Aspirin 650 mg, n=49

(3) Placebo, n=55

TOTPAR 6:

(1) 7.0

(3) 1.8

(1) 16/58

(3) 0/55

No usable data

No data

at 6hrs:

(1) 45/58

(3) 52/55

Mehlisch 1990

(1) Paracetamol 1000 mg, n=306

(2) Ibuprofen 400 mg, n=306

(3) Placebo, n=85

(1) 4.1

(3) 1.2

(1) 131/306

(3) 9/85

No data

No data

No data

Mehlisch 1995

(1) Paracetamol 1000 mg, n=101

(2) Ibuprofen 400 mg, n=98

(3) Placebo, n=40

(1) 8.4

(3) 2.6

(1) 35/101

(3) 1/40

(1) 31/101

(3) 1/40

Median:

(1) 4.2

(3) 1.4

at 6 hrs:

(1) 60

(3) 88

Moller 2000

(1) Paracetamol tablet 1000 mg, n=60

(2) Placebo tablet, n=60

(3) Paracetamol effervescent 1000 mg, n = 60

(4) Placebo effervescent, n=62

TOTPAR 6:

(1) 4.4

(2) 0.8

(3) 3.7

(4) 0.8

(1) 15/60

(2) 0/60

(3) 12/60

(4) 0/62

No usable data

Median:

(1) 2.7

(2) 1.0

(3) 2.1

(4) 1.0

(1) 73

(2) 93

(3) 85

(4) 100

Moller 2005

(1) Paracetamol tablet 1000 mg, n=50

(2) Propacetamol 2000 mg iv bolus, n=50

(3) Propacetamol 2000 mg 15 min infusion, n=50

(4) Placebo, n=25

TOTPAR 6:

(1) 9.4

(4) 5.0

(1) 22/50

(4) 4/25

No data

Median:

(1) 4.6

(4) 1.1

No data

Olson 2001

(1) Paracetamol 1000 mg, n=66

(2) Ibuprofen liquigel 400 mg, n=67

(3) Ketoprofen 25 mg, n=67

(4) Placebo, n=39

TOTPAR 6:

(1) 13.3

(4) 4.3

(1) 41/66

(4) 5/39

at 6 hrs:

(1) 57%

(4) 11%

Median:

(1) >6

(4) 1.3

at 6 hrs:

(1) 25/66

(4) 31/39

Pinto 1984

(1) Paracetamol 500 mg, n = 29

(2) Dipyrone 500 mg, n=29

(3) Placebo, n = 29

TOTPAR 4:

(1) 11.4

(3) 5.6

(1) 24/29

(3) 10/29

No usable data

No data

at 4 hrs:

(1) 0

(3) 28

Rubin 1984

(1) Paracetamol 1000 mg, n=123

(2) Paracetamol+aspirin 648/648 mg, n=123

(3) Aspirin+caffeine 800/6.5 mg, n=121

(4) Placebo, n=109

%max SPID:

(1) 53.3

(4) 36.6

(1) 86/123

(4) 52/109

no data

no data

at 4 hrs:

(1) 1/123

(4) 15/109

Rubinstein 1986

(1) Paracetamol 500 mg, n=30

(2) Dypyrone 500 mg, n=30

(3) Placebo, n=30

TOTPAR 4:

(1) 10.1

(3) 4.7

(1) 22/30

(3) 8/30

No usable data

No data

at 4 hrs:

(1) 7

(3) 20

Sakata 1986

(1) Paracetamol 1000 mg, n=30

(2) Dipyrone 1000 mg, n=30

(3) Placebo, n=27

TOTPAR 4:

(1) 8.4

(3) 2.8

(1) 17/30

(3) 3/27

No usable data

No data

No data

Santos Pereira 1986

(1) Paracetamol 1000 mg, n=28

(2) Dipyrone 1000 mg, n=28

(3) Placebo, n=29

SPID 4:

(1) 6.4

(3) 2.1

(1) 22/28

(3) 7/29

No usable data

No data

(1) 0

(3) 38

Schachtel 1989

(1) Paracetamol 1000 mg, n=37

(2) Ibuprofen 400 mg, n=36

(3) Placebo, n=38

TOTPAR 6:

(1) 7.9

(3) 5.5

(1) 20/37

(3) 13/38

No usable data

No data

at 6 hrs:

(1) 35

(3) 58

Seymour 1996

(1) Paracetamol 500 mg n=41

(2) Paracetamol 1000 mg n=41

(3) Ketoprofen 12.5 mg n=42

(4) ketoprofen 25 mg n=41

(5) Placebo, n=41

VAS SPID 6:

(1) 135.4

(2) 150.0

(5) 75

(1) 19/41

(2) 21/41

(5) 10/41

at 6 hr:

(1) 15/41

(2) 23/41

(5) 8/41

Median:

(1) 2.8

(2) 4.1

(5) 1.8

(1) 32/40

(2) 33/40

(5) 38/39

Seymour 2003

(1) Paracetamol 1000 mg, n=62

(2) Aspirin (soluble) 900 mg, n=59

(3) Placebo, n=32

SPID 4 (VAS):

(1) 40.7

(3) 22.6

(1) 13/62

(3) 3/32

at 4 hrs:

(1) 53%

(3) 10%

Median:

(1) 1.6

(3) 1.1

At 4 hrs:

(1) 74%

(3) 91%

Sunshine 1986

(1) Paracetamol 650 mg, n=30

(2) Paracetamol+codeine 650/60 mg, n=31

(3) Flurbiprofen 50 mg, n=31

(4) Flurbiprofen 100 mg, n=29

(5) Zomepirac 100 mg, n=31

(6) Placebo, n=30

TOTPAR 6:

(1) 11.1

(6) 8.3

(1) 15/30

(6) 10/30

No usable data

No data

at 6 hrs:

(1) 47

(6) 43

Sunshine 1989

(1) Paracetamol 650 mg, n=75

(2) Paracetamol+phenyltoloxamine 650/60 mg, n=75

(3) Placebo, n=50

TOTPAR 6:

(1) 7.3

(3) 2.2

(1) 22/75

(3) 0/50

No usable data

No data

at 6 hrs:

(1) 3

(3) 16

Sunshine 1993

(1) Paracetamol 650mg, n=48

(2) Paracetamol+oxycodone 650/10 mg, n=48

(3) Ketoprofen 50 mg, n=48

(4) Ketoprofen 100 mg, n=48

(5) Placebo, n=48

TOTPAR 6:

(1) 10.4

(5) 9.7

(1) 22/48

(5) 20/48

No usable data

Of pts with onset:

Median:

(1) 7 .0

(5) 6.0

No usable data

at 8 hrs:

(1) 88

(5) 73

Winnem 1981

(1) Paracetamol 1000 mg, n=20

(2) Tiaramide 100 mg, n=20

(3) Tiaramide 200 mg, n=19

(4) Placebo, n=20

SPID 6:

(1) 4.3

(4) 1.7

(1) 9/20

(4) 3/20

No data

No usable data

at 6 hrs:

(1) 24

(4) 45

Winter 1979

(1) Paracetamol 325 mg, n=49

(2) Orphenadrine 25 mg, n=50

(3) Paracetamol+orphenadrine 325/25 mg, n=50

(4) Placebo, n=51

SPID 6:

(1) 9.5

(4) 5.9

(1) 34/49

(4) 22/51

No data

Mean:

(1) 3.1

(4) 2.9

at 6 hrs:

(1) 67

(4) 75

Winter 1983

(1) Paracetamol 1000 mg, n=41

(2) Paracetamol+caffeine 1000/130 mg, n=40

(3) Caffeine 130 mg, n=42

(4) Placebo, n=41

TOTPAR 4:

(1) 7.4

(4) 4.0

(1) 20/41

(4) 9/41

No data

No data

at 4 hrs:

(1) 2

(4) 2

Young 1979

Study 1:

(1) Paracetamol 650 mg, n=30

(2 Paracetamol+butorphanol 650/4 mg, n=30

(3) Butorphanol 4 mg, n=30

(4) Placebo, n=29

TOTPAR 4:

(1) 7.3

(4) 7.2

(1) 15/30

(4) 14/29

No usable data

No data

No data
Figuras y tablas -
Table 1. Summary of Outcomes: analgesia and use of rescue medication
Ir a la tabla de la revisión
Table 2. Summary of Outcomes: adverse events and withdrawals

Adverse events

Withdrawals

Study ID

Treatment

Any

Serious

Adverse event

Other

Bentley 1987

(1) Paracetamol 1000 mg, n=41

(2) Paracetamol+codeine 1000/60 mg, n=41

(3) Codeine 60 mg, n=21

(4) Placebo, n=17

(1) 21/42

(4) 9/19

None reported

None reported

7 excluded form efficacy analysis due to invalid data, 1 did not return forms

Berry 1975

(1) Paracetamol 1000 mg, n=76

(2) Propoxyphene 65 mg, n=73

(3) Placebo, n=76

None related to medication

None reported

None reported

None reported

Bhounsule 1990

(1) Paracetamol 1000 mg, n=20

(2) Ibuprofen 400 mg, n=20

(3) Aspirin 600 mg, n=20

(4) Analgin 500 mg, n=20

(5) Placebo, n=20

None related to medication

None reported

None reported

None

Bjune 1996

(1) Paracetamol 1000 mg, n=50

(2) Paracetamol+codeine 800/60 mg, n=50

(3) Placebo, n=25

(1) 10/50

(3) 1/25

None

None

7 paracetamol, 4 placebo pts excluded due to invalid data

Cooper 1980

(1) Paracetamol 500 mg, n=37

(2) Oxycodone 5 mg, n=42

(3) Paracetamol+oxycodone 500/5 mg, n= 5

(4) Paracetamol+oxycodone 1000/5 mg, n=40

(5) Paracetamol+oxycodone 1000/10 mg, n=45

(6) Placebo, n=38

(1) 3/37

(6) 6/38

None reported

None reported

Exclusions due to invalid data, numbers not given per group

Cooper 1981

(1) Paracetamol 650 mg, n=37

(2) Paracetamol+codeine 650/60 mg, n=42

(3) Paracetamol+d‐propoxyphene 650/100 mg, n=42

(4) Ibuprofen 200 mg, n=42

(5) Placebo, n=37

(1) 12/37

(5) 4/37

None

None

Exclusions due to invalid data, numbers not given per group

Cooper 1986

(1) Paracetamol 1000 mg, n=38

(2) Paracetamol+codeine+caffeine 1000/16/30 mg, n=39

(3) Placebo, n=22

No data

None

None

6 paracetamol, 1 placebo excluded due to invalid data

Cooper 1988

(1) Paracetamol 600 mg, n=36

(2) Paracetamol+codeine 600+60 mg, n=31

(3) Placebo, n=40

No data

No data

None

Exclusions due to invalid data, numbers not given per group

Cooper 1989

(1) Paracetamol 1000 mg, n=59

(2) Ibuprofen 400 mg, n=61

(3) Placebo, n=64

(1) 11/63

(3) 7/64

None

None

Exclusions due to invalid data, numbers not given per group

Cooper 1991a

(1) Paracetamol 650 mg, n=37

(2) Paracetamol+codeine 650/60 mg, n=39

(3) Zomepirac 100 mg, n=23

(4) Flurbiprofen 50 mg, n=42

(5) Flurbiprofen 100 mg, n=41

(6) Placebo, n=44

(1) 6/37

(6) 7/44

None reported

None reported

Exclusions due to invalid data, numbers not given per group

Cooper 1998

(1) Paracetamol 1000mg n=50

(2) Ketoprofen 100 mg, n=51

(3) Ketoprofen 1000 mg, n=50

(4) Placebo n=26

(1) 25/50

(4) 4/26

None

None

None

Dionne 1994

(1) Paracetamol 650 mg, n=27

(2) Paracetamol+codeine 650/60 mg, n=24

(3) Flurbiprofen 50 mg, n=25

(4) Flurbiprofen 100 mg, n=22

(5) Placebo, n=25

(1) 7/27

(5) 9/24

None reported

None reported

11 excluded from analysis: enrolled twice, early rescue medication, asleep during observations, lost to follow up

Dolci 1994

(1) Paracetamol 500 mg, n=72

(2) Piroxicam 20 mg, n=76

(3) Piroxicam cyclodextrin =20 mg, n=74

(4) Placebo, n=76

(1) 7/80

(4) 6/82

None reported

(1) 2/80

(4) 1/82

Exclusions due to invalid data, numbers not given per group

Edwards 2002

(1) Paracetamol 650 mg, n=340

(2) Placebo, n=339

5 dental studies included in meta‐analysis

(1) 54/340

(2) 58/337

None reported

(1) 1/340

(2)2/337

No data

Edwards 2002

(1) Paracetamol 975 mg, n=100

(2) Placebo, n=100

2 gynae or ortho studies in meta‐analysis

No data

No data

No data

No data

Fassolt 1983

(1) Paracetamol 650 mg, n=29

(2) Suprofen 200 mg, n=32

(3) Suprofen 400 mg, n=28

(4) Paracetamol+suprofen 650/100 mg, n=29

No data

None reported

No data

No data

Forbes 1982

(1) Paracetamol 600 mg, n=34

(2) Paracetamol+codeine 600/60 mg, n=31

(3) Diflusinal 500 mg, n=32

(4) Diflusinal 1000 mg, n=32

(5) Placebo, n=30

No usable data

None

None

None reported

Forbes 1983

(1) Paracetamol 600 mg, n=26

(2) Paracetamol+codeine 600/60 mg, n=26

(3) Diflusinal 500 mg, n=26

(4) Diflusinal 1000 mg, n=28

(5) Placebo, n=26

(1) 11/26

(5) 4/26

None reported

None

None

Forbes 1984a

(1) Paracetamol 650 mg, n=39

(2) Phenyltoloxamine 60 mg, n=33

(3) Patacetamol+phenyltoxolamine 650/60 mg, n=40

(4) Placebo, n=36

(1) 1/423

(4) 2/40

None

None

Exclusions due to invalid data, numbers not given per group

Forbes 1984b

(1) Paracetamol 650 mg, n=31

(2) Nalbuphine 30 mg, n=32

(3) Paracetamol+nalbuphine 650/30 mg, n=33

(4) Placebo, n=33

(1) 9/33

(4) 8/33

None

None

Three pts excl from efficacy analysis due to invalid data

Forbes 1989

(1) Paracetamol 600 mg, n=22

(2) Paracetamol+codeine 600/60 mg, n=17

(3) Flurbiprofen 100 mg, n=26

(4) Placebo, n=23

(1) 3/26

(4) 4/26

None

None

10 pts excl from efficacy analysis due to invalid data

Forbes 1990

(1) Paracetamol 600 mg, n=36

(2) Paracetamol+codeine 600/60 mg, n=38

(3) Ketorolac 10 mg, n=31

(4) Ketorolac 20 mg, n=35

(5) Ibuprofen 400 mg, n=32

(6) Placebo, n=34

(1) 5/41

(6) 0/38

None

None

37 pts excl from efficacy analysis due to invalid data

Haglund 2006

(1) Paracetamol 1000 mg, n=20

(2) Rofecoxib/paracetamol 50/1000mg, n=34

(3) Rofecoxib 50 mg, n=36

(4) Placebo, n=17

No usable data

None

None reported

5 ‐ inadequately filled in questionnaires. Not included in final analysis

Hersch 2000

(1) Paracetamol capsule 1000 mg, n=63

(2) Ibuprofen liquigel 200 mg, n=61

(3) Ibuprofen liquigel 400 mg n=59

(4) Placebo, n=27

(1) 12/63

(4) 7/27

None

None

None

Honig 1984

(1) Paracetamol 600 mg, n = 28

(2) Paracetamol+codeine 600/60 mg, n=28

(3) Codeine 60 mg, n=28

(4) Placebo, n=25

No data

none

None reported

None reported

Jain 1986

(1) Paracetamol 650 mg, n=30

(2) Nalbuphine 30 mg, n=34

(3) Paracetamol+nalbuphine 650/30 mg, n=32

(4) Placebo, n=32

(1) 9/30

(4) 6/32

None reported

None reported

6 pts excl from efficacy analysis due to invalid data

Kiersch 1994

(1) Paracetamol 1000 mg, n=92

(2) Naproxen Na 440 mg, n=89

(3) Placebo, n=45

(1) 31/94

(3) 13/45

None

(1) 2/94 (vomiting within 10 mins)

(3) 0/45

None

Kubitzek 2003

(1) Paracetamol 1000 mg, n=78

(2) Diclofenac K 25 mg, n= 83

(3) Placebo, n=84

48 hrs:

(1) 4/78

(3) 2/84

None

None

1 in placebo group due to dosing protocol violation

Laska 1983 (Study 3)

(1) Paracetamol 500 mg, n=81

(2) Paracetamol 1000 mg, n=81

(3) Paracetamol 1500 mg, n=81

(4) Placebo, n=57

No data

No data

None reported

Various protocol violations ‐ groups not given

Lenhert 1990

(1) Paracetamol 1000 mg, n=49

(2) Aspirin 1000 mg, n=45

(3) Placebo, n=40

(1) 5/49

(2) 4/40

None reported

None reported

11 did not take the medication, 3 were lost to follow up and 3 for various protocol violations.

McQuay 1988

(1) Paracetamol 1000 mg, n=30

(2) Bromfenac 5 mg, n=30

(3) Bromfenac 10 mg, n=30

(4) Bromfenac 25 mg, n=30

(5) Placebo, n=30

(1) 6/30

(2) 6/30

None

None reported

8 excluded from analysis due to invalid data

Mehlisch 1984

(1) Paracetamol 1000 mg, n=58

(2) Aspirin 650 mg, n=49

(3) Placebo, n=55

No usable data

No data

None

162 analysed. Exclusions: 9 failed to comply with protocol & 3 were lost to follow up.

Mehlisch 1990

(1) Paracetamol 1000 mg, n=306

(2) Ibuprofen 400 mg, n=306

(3) Placebo, n=85

(1) 32/307

(3) 12/85

None reported

None reported

2 Paracetamol lost to follow up, 1 Paracetamol entered in trial twice (invalid data)

Mehlisch 1995

(1) Paracetamol 1000 mg, n=101

(2) Ibuprofen 400 mg, n=98

(3) Placebo, n=40

 

(1) 17/101

(3) 4/40

None

None

None

Moller 2000

(1) Paracetamol tablet 1000 mg, n=60

(2) Placebo tablet, n=60

(3) Paraceamol effervescent 1000 mg, n=60

(4) Placebo effervescent, n=62

(1) 24/60

(2) 21/60

(3) 24/60

(4) 35/60

None

None reported

None

Moller 2005

(1) Paracetamol tablet 1000 mg, n=50

(2) Propacetamol 2000 mg iv bolus, n=50

(3) Propacetamol 2000 mg 15 min infusion, n=50

(4) Placebo, n=25

At 7 days:

(1) 21/50

(4) 12/25

1 in propacetamol iv bolus group

None

None

Olson 2001

(1) Paracetamol 1000 mg, n=66

(2) Ibuprofen liquigel 400 mg, n=67

(3) Ketoprofen 25 mg, n=67

(4) Placebo, n=39

At 6 hrs:

(1) 10/66

(4) 2/39

None

None

None

Pinto 1984

(1) Paracetamol 500 mg, n=29

(2) Dipyrone 500 mg, n=29

(3) Placebo, n=29

(1) 0/29

(3) 0/29

None reported

No data

No data

Rubin 1984

(1) Paracetamol 1000 mg, n=123

(2) Paracetamol+aspirin 648/648 mg, n=123

(3) Aspirin+caffeine 800/6.5 mg, n=121

(4) Placebo, n=109

(1) 6/123

(4) 6/109

None

None

None

Rubinstein 1986

1) Paracetamol 500 mg, n=30

2) Dypyrone 500 mg, n=30

3) Placebo, n=30

(1) 1/30

(3) 0/30

None reported

None

None

Sakata 1986

(1) Paracetamol 1000 mg, n=30

(2) Dipyrone 1000 mg, n=30

(3) Placebo, n=27

No data

No data

No data

No data

Santos Pereira 1986

(1) Paracetamol 1000 mg, n=28

(2) Dipyrone 1000 mg, n=28

(3) Placebo, n = 29

No data

No data

No data

No data

Schachtel 1989

(1) Paracetamol 1000 mg, n=37

(2) Ibuprofen 400 mg, n=36

(3) Placebo, n=38

                      

None

None

None

None

Seymour 1996

(1) Paracetamol 500 mg, n=41

(2) Paracetamol 1000 mg, n=41

(3) Ketoprofen 12.5 mg, n= 42

(4) ketoprofen 25 mg, n=41

(5) Placebo, n=41

No patients reported any AE

None

None

2 placebo, 1 from each paracetamol group excl from efficacy analysis due to early rescue medication

Seymour 2003

(1) Paracetamol 1000 mg, n=62

(2) Aspirin (soluble) 900 mg, n=59

(3) Placebo, n=32

At 4 hrs:

(1) 39/62

(3) 28/32

None reported

None reported

None

Sunshine 1986

(1) Paracetamol 650 mg, n=30

(2) Paracetamol+codeine 650/60 mg, n=31

(3) Flurbiprofen 50 mg, n=31

(4) Flurbiprofen 100 mg, n=29

(5) Zomepirac 100 mg, n=31

(6) Placebo, n=30

               

(1) 1/30

(6) 1/30

  

None

None

None

Sunshine 1989

(1) Paracetamol 650 mg, n=75

(2) Paracetamol+phenyltoloxamine 650/60 mg, n=75

(3) Placebo, n=50

(1) 0/75

(3) 0/50

None

None

None

Sunshine 1993

(1) Paracetamol 650 mg, n=48

(2) Paracetamol+oxycodone 650/10 mg, n=48

(3) Ketoprofen 50 mg, n=48

(4) Ketoprofen 100 mg, n=48

(5) Placebo, n=48

No details for single dose phase

No cases of possible clinical concern

None reported

None

Winnem 1981

(1) Paracetamol 1000 mg, n=20

(2) Tiaramide 100 mg, n=20

(3) Tiaramide 200 mg, n=19

(4) Placebo, n=20

None

None

None

1 excl from analysis for vomiting medication within 30 mins.

Winter 1979

(1) Paracetamol 325 mg, n=49

(2) Orphenadrine 25 mg, n=50

(3) Paracetamol+orphenadrine 325/25 mg, n=50

(4) Placebo, n=51

(1) 0/49

(4) 1/51

None

None

None reported

Winter 1983

(1) Paracetamol 1000 mg, n=41

(2) Paracetamol+caffeine 1000/130 mg, n=40

(3) Caffeine 130 mg, n=42

(4) Placebo, n=41

(1) 0/41

(4) 1/41

None

None

None reported
Figuras y tablas -
Table 2. Summary of Outcomes: adverse events and withdrawals
Ir a la tabla de la revisión
Comparison 1. Paracetamol all doses versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

51

5762

Risk Ratio (M‐H, Fixed, 95% CI)

2.42 [2.21, 2.64]

2 Participants using rescue medication over 4 to 6 hours Show forest plot

32

3182

Risk Ratio (M‐H, Fixed, 95% CI)

0.74 [0.71, 0.78]

3 Participants with any adverse event Show forest plot

35

4283

Risk Ratio (M‐H, Fixed, 95% CI)

1.12 [0.97, 1.29]

4 Participants with any adverse event, dental Show forest plot

25

3439

Risk Ratio (M‐H, Fixed, 95% CI)

1.07 [0.92, 1.24]

5 Participants with any adverse event, surgical Show forest plot

10

846

Risk Ratio (M‐H, Fixed, 95% CI)

1.56 [1.04, 2.33]
Figuras y tablas -
Comparison 1. Paracetamol all doses versus placebo
Ir a la tabla de la revisión
Comparison 2. Paracetamol 325 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 2. Paracetamol 325 mg versus placebo
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Comparison 3. Paracetamol 500 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

6

561

Risk Ratio (M‐H, Fixed, 95% CI)

1.91 [1.57, 2.32]

2 Participants with at least 50% pain relief over 4 to 6 hours, dental Show forest plot

3

305

Risk Ratio (M‐H, Fixed, 95% CI)

1.89 [1.44, 2.50]

3 Participants with at least 50% pain relief over 4 to 6 hours, surgical Show forest plot

3

256

Risk Ratio (M‐H, Fixed, 95% CI)

1.92 [1.46, 2.52]

4 Participants using rescue medication over 4 to 6 hours Show forest plot

3

290

Risk Ratio (M‐H, Fixed, 95% CI)

0.56 [0.45, 0.69]

5 Participants with any adverse event Show forest plot

3

319

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.38, 1.90]
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Comparison 3. Paracetamol 500 mg versus placebo
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Comparison 4. Paracetamol 600‐650 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

19

1886

Risk Ratio (M‐H, Fixed, 95% CI)

2.42 [2.05, 2.84]

2 Participants with at least 50% pain relief over 4 to 6 hours, dental Show forest plot

10

1276

Risk Ratio (M‐H, Fixed, 95% CI)

3.05 [2.42, 3.83]

3 Participants with at least 50% pain relief over 4 to 6 hours, surgical Show forest plot

9

610

Risk Ratio (M‐H, Fixed, 95% CI)

1.79 [1.41, 2.26]

4 Participants using rescue medication over 4 to 6 hours Show forest plot

13

917

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.77, 0.93]

5 Participants with any adverse event Show forest plot

13

1522

Risk Ratio (M‐H, Fixed, 95% CI)

1.18 [0.93, 1.50]
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Comparison 4. Paracetamol 600‐650 mg versus placebo
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Comparison 5. Paracetamol 975‐1000 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

28

3232

Risk Ratio (M‐H, Fixed, 95% CI)

2.67 [2.36, 3.02]

2 Participants with at least 50% pain relief over 4 to 6 hours, dental Show forest plot

18

2171

Risk Ratio (M‐H, Fixed, 95% CI)

4.14 [3.32, 5.17]

3 Participants with at least 50% pain relief over 4 to 6 hours, surgical Show forest plot

10

1075

Risk Ratio (M‐H, Fixed, 95% CI)

1.70 [1.49, 1.95]

4 Participants using rescue medication over 4 to 6 hours Show forest plot

17

1980

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.68, 0.77]

5 Participants with any adverse event Show forest plot

19

2342

Risk Ratio (M‐H, Fixed, 95% CI)

1.10 [0.93, 1.32]
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Comparison 5. Paracetamol 975‐1000 mg versus placebo
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Comparison 6. Paracetamol 1500 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
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Comparison 6. Paracetamol 1500 mg versus placebo
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Comparison 7. Paracetamol versus placebo, sensitivity analysis

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Quality score of 3 or more Show forest plot

48

5549

Risk Ratio (M‐H, Fixed, 95% CI)

2.48 [2.27, 2.72]

2 Quality of 2 Show forest plot

3

214

Risk Ratio (M‐H, Fixed, 95% CI)

2.17 [1.59, 2.97]

3 More than 40 patients in each arm, 975/1000mg paracetamol vs placebo, quality score of three of more, dental Show forest plot

11

1562

Risk Ratio (M‐H, Fixed, 95% CI)

4.47 [3.41, 5.85]

4 Less than 40 patients in each arm, 975/1000mg paracetamol vs placebo, quality score of three of more, dental Show forest plot

2

97

Risk Ratio (M‐H, Fixed, 95% CI)

5.61 [2.06, 15.33]
Figuras y tablas -
Comparison 7. Paracetamol versus placebo, sensitivity analysis
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