Studies

CD3+ (%)

CD4+ (%)

CD8+ (%)

WBC

Side effects

NK cell (%)

IgG (g/L)

IgA (g/L)

IgM (g/L)

Xiao 1998

Number of patients with WBC less than 3.0 x 10^9 per L:

TCM + chemo group: 7/50 (14%)

chemo alone group: 14/25 (56%)

Rate difference 42% (95% c.i. 20 to 60%)

TCM + chemo group: reduced appetite 9/50 (18%), nausea with vomiting 11/50 (22%), hair loss 8/50 (16%).

chemo alone group: reduced appetite 13/25 (52%), nausea with vomiting 14/25 (56%), hair loss 15/25 (60%)

Rate differences:
Reduced appetite 34% (95% c.i. 12% to 54%)
Nausea and Vomiting 34% (95% c.i. 11% to 54%)
Hair Loss 44% (95% c.i. 21% to 62%)

He 1995

Huangqi compounds decoction group: 4400/ml (95% c.i. 4144 to 4655)

Shenbaibao group: 4100/ml (95% c.i. 3841 to 4358)

Berbamine Hydrochloride group: 3590/ml (95% c.i. 3320 to 3859)

Guo 1999

Huangqi compounds decoction + chemo group: 49.3 (95% c.i. 48.4 to 50.2)

Chemo alone group: 42.9 (95% c.i. 41.9 to 43.9).

Difference (decoction +chemo vs. chemo alone) 6.4% (95% c.i.: 5.1% to 7.7%)

Huangqi compounds decoction + chemo group: 44.6 (95% c.i. 43.6 to 45.6)

Chemo alone group: 38.8 (95% c.i. 38.1 to 39.5)

Difference (decoction +chemo vs. chemo alone) 5.8 (95% c.i. 4.6 to 7.0)

Huangqi compounds decoction + chemo group: 26.9 (95% c.i. 25.4 to 28.4)

Chemo alone group: 24.6 (95% c.i. 23.7 to 25.5)

Difference (decoction+chemo vs. chemo alone) 2.3 (0.5 to 4.1)

Number of patients with WBC less than 3.0 x 10^9 per L:

Huangqi compounds decoction + chemo group: 7/38 (18%)

Chemo alone group 15/31 (48%)

Rate difference: 30% (95% c.i. 7% to 49%)

Huangqi compounds decoction + chemo group: nausea 16/38 (42%), vomiting10/38 (26%), fatigue 14/38 (37%)

Chemo alone group: nausea 25/31 (81%), vomiting 18/31 (58%), fatigue 21/31 (68%)

Rate differences:
Nausea 39% (95% c.i. 16% to 56%)
Vomiting 32% (95% c.i. 8% to 51%)
Fatigue 31% (95% c.i. 7% to 50%)

Huangqi compounds decoction + chemo group: 6.32 (95% c.i. 5.1 to 7.5)

Chemo alone group: 4.32 (95% c.i. 2.6 to 6.0)

Difference 2.0 (95% c.i. 0 to 4.0)

Huangqi compounds decoction + chemo group: 0.67 (95 % c.i. 0 to 1.4)

Chemo alone group: 0.51 (95% c.i. 0 to 2.6)

Huangqi compounds decoction + chemo group: 0.71 (95% c.i. 0 to 1.5)

Chemo alone group: 0.38 (95% c.i. 0 to 1.4)

Li 2000

Huangqi compounds decoction alone group: 63.3 (95% c.i. 59.5 to 67.1);
Huangqi plus chemotherapy group: 59.4 (95% c.i. 55.3 to 63.5); Chemotherapy alone group: 57.2 (95% c.i. 51.8 to 62.6);
Difference (chemo+decoction vs, chemo alone) 2.2% (95%c.i. ‐4.2% to +8.6%)

Huangqi compounds decoction alone group: 39.3 (95% c.i. 35.7 to 42.9);
Huangqi plus chemotherapy group: 38.8 (95% c.i. 34.2 to 43.4);
Chemotherapy alone group: 37.8 (95% c.i. 34.0 to 41.6); Difference (decoction+chemo vs. chemo alone) 1.0 (95% c.i. ‐4.7 to +6.7)

Huangqi compounds decoction alone goup: 32.2 (95% c.i. 28.8 to 35.6);
Huangqi plus chemotherapy group: 33.4 (95% ci.i 28.4 to 38.4);
Chemotherapy alone group: 30.5 (95% c.i.26.6 to 34.4); Difference (decoction+chemo vs. chemo alone) 2.9 (95% c.i. ‐3.1 to +8.9)

Huangqi compounds decoction alone group: 36.4 (95% c.i. 33.6 to 39.2)

Huangqi plus chemotherapy group: 35.5 (95% c.i. 32.6 to 38.4)

Chemotherapy alone group: 34.7 (95% c.i. 31.8 to 37.6)

Huangqi compounds decoction alone group: 18.11 (95% c.i. 14.5 to 21.7)

Huangqi plus chemotherapy group: 17.35 (95% c.i. 14.5 to 20.2)

Chemotherapy group: 15.74 (95% c.i. 14.3 to 17.2)

Huangqi compounds decoction alone group: 2.35 (95% c.i. 2.1 to 2.6)

Huangqi plus chemotherapy group: 2.59 (95% c.i. 1.9 to 3.3)

Chemotherapy group: 2.08 (95% c.i. 1.7 to 2.5)

Huangqi compounds decoction alone group: 1.70 (95% c.i. 1.3 to 2.1)

Huangqi plus chemotherapy group: 1.65 (95% c.i. 1.3 to 2.0)

Chemotherapy group: 1.55 (95% c.i. 1.2 to 1.9)