| 1 Mortality per antibiotic (ABX) treatment Show forest plot | 25 | 5444 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.14 [0.84, 1.55] |
|
| 1.1 Quinolone (atypical arm) | 19 | 3698 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.98 [0.69, 1.39] |
| 1.2 Macrolide (atypical arm) | 4 | 540 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.25 [0.52, 3.01] |
| 1.3 Combined quinolone and macrolide (atypical arm) | 1 | 808 | Risk Ratio (M‐H, Fixed, 95% CI) | 2.29 [0.81, 6.44] |
| 1.4 Pristinamycine (atypical arm) | 1 | 398 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.98 [0.37, 10.69] |
| 2 Mortality per age Show forest plot | 25 | 5444 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.14 [0.84, 1.55] |
|
| 2.1 Mean age under 65 years old | 15 | 3820 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.21 [0.75, 1.94] |
| 2.2 Mean age over 65 years old | 8 | 1439 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.10 [0.72, 1.69] |
| 2.3 Data unavailable | 2 | 185 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.0 [0.34, 2.93] |
| 3 Mortality ‐ per geographical area Show forest plot | 25 | 5444 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.14 [0.84, 1.55] |
|
| 3.1 Europe | 14 | 3209 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.22 [0.79, 1.89] |
| 3.2 North America | 3 | 232 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.42 [0.52, 3.86] |
| 3.3 Other | 8 | 2003 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.62, 1.60] |
| 4 Mortality per allocation generation Show forest plot | 25 | 5444 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.14 [0.84, 1.55] |
|
| 4.1 A | 10 | 1953 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.07 [0.68, 1.68] |
| 4.2 B | 15 | 3491 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.20 [0.79, 1.81] |
| 4.3 C | 0 | 0 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Mortality per allocation concealment Show forest plot | 25 | 5444 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.14 [0.84, 1.55] |
|
| 5.1 A | 7 | 1590 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.05 [0.66, 1.65] |
| 5.2 B | 18 | 3854 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.22 [0.81, 1.83] |
| 5.3 C | 0 | 0 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6 Mortality per blinding Show forest plot | 25 | 5444 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.14 [0.84, 1.55] |
|
| 6.1 Non‐blinded | 16 | 2290 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.04 [0.72, 1.50] |
| 6.2 Single‐blind | 0 | 0 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6.3 Double or triple‐blind | 9 | 3154 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.37 [0.79, 2.38] |
| 7 Mortality ‐ ITT analysis Show forest plot | 12 | 2143 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.23 [0.70, 2.15] |
|
| 7.1 ITT (type 1) | 12 | 2143 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.23 [0.70, 2.15] |
| 8 Clinical failure per antibiotic (ABx) treatment Show forest plot | 28 | 5419 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.84, 1.04] |
|
| 8.1 Quinolone (atypical arm) | 21 | 3704 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.89 [0.79, 1.02] |
| 8.2 Macrolide (atypical arm) | 5 | 536 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.11 [0.76, 1.62] |
| 8.3 Combined quinolone and macrolide (atypical arm) | 1 | 808 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.75, 1.17] |
| 8.4 Pristinamycine (atypical arm) | 1 | 371 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.18 [0.77, 1.81] |
| 9 Clinical failure per age Show forest plot | 28 | 5419 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.84, 1.04] |
|
| 9.1 Mean age under 65 years old | 15 | 3554 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.81, 1.06] |
| 9.2 Mean age over 65 years old | 8 | 1439 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.91 [0.75, 1.10] |
| 9.3 Data unavailable | 5 | 426 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.07 [0.77, 1.50] |
| 10 Clinical failure per geographical area Show forest plot | 28 | 5419 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.84, 1.04] |
|
| 10.1 Europe | 15 | 3084 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.85 [0.74, 0.98] |
| 10.2 North America | 3 | 232 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.59, 1.45] |
| 10.3 Other | 10 | 2103 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.06 [0.90, 1.24] |
| 11 Clinical failure per allocation generation Show forest plot | 28 | 5419 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.84, 1.04] |
|
| 11.1 A | 10 | 1878 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.82, 1.19] |
| 11.2 B | 17 | 3467 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.79, 1.02] |
| 11.3 C | 1 | 74 | Risk Ratio (M‐H, Fixed, 95% CI) | 7.29 [0.41, 130.64] |
| 12 Clinical failure per allocation concealment Show forest plot | 28 | 5419 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.84, 1.04] |
|
| 12.1 A | 7 | 1583 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.82, 1.19] |
| 12.2 B | 20 | 3762 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.80, 1.02] |
| 12.3 C | 1 | 74 | Risk Ratio (M‐H, Fixed, 95% CI) | 7.29 [0.41, 130.64] |
| 13 Clinical failure per blinding Show forest plot | 28 | 5419 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.84, 1.04] |
|
| 13.1 Non‐blinded | 18 | 2415 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.77, 1.05] |
| 13.2 Single‐blind | 0 | 0 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13.3 Double or triple‐blind | 10 | 3004 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.97 [0.84, 1.11] |
| 14 Clinical failure ‐ ITT analysis Show forest plot | 28 | 5682 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.85, 1.02] |
|
| 14.1 ITT studies (type 1) | 7 | 1232 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.76, 1.12] |
| 14.2 Dropouts assumed as failure (type 2) | 15 | 3849 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.94 [0.84, 1.05] |
| 14.3 Non‐ITT, dropouts cannot be calculated (type 3) | 6 | 601 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.85 [0.63, 1.15] |
| 15 Clinical failure ‐ pneumococcal pneumonia Show forest plot | 18 | 1021 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.22 [0.88, 1.70] |
|
| 16 Clinical failure ‐ atypical pathogens Show forest plot | 4 | 158 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.52 [0.24, 1.10] |
|
| 17 Clinical failure ‐ Legionella pneumophilae Show forest plot | 5 | 43 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.17 [0.05, 0.63] |
|
| 18 Clinical failure per sponsorship Show forest plot | 28 | 5419 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.84, 1.04] |
|
| 18.1 Sponsored trials | 21 | 4540 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.97 [0.86, 1.08] |
| 18.2 Non‐sponsored trials | 3 | 288 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.02 [0.64, 1.62] |
| 18.3 Unclear sponsorship | 4 | 591 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.67 [0.49, 0.93] |
| 19 Bacteriological failure Show forest plot | 21 | 2310 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.80 [0.65, 0.98] |
|
| 19.1 Overall | 21 | 2310 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.80 [0.65, 0.98] |
| 20 Bacteriological failure per allocation generation Show forest plot | 21 | 2310 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.80 [0.65, 0.98] |
|
| 20.1 A | 8 | 708 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.61, 1.32] |
| 20.2 B | 13 | 1602 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.76 [0.59, 0.96] |
| 21 Adverse events ‐ total Show forest plot | 24 | 4918 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.02 [0.93, 1.13] |
|
| 22 Adverse events ‐ gastrointestinal events Show forest plot | 16 | 4129 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.70 [0.53, 0.92] |
|
| 23 Adverse events ‐ requiring discontinuation of treatment Show forest plot | 12 | 3806 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.01 [0.72, 1.41] |
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