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Table 1. Summary of salient characteristic of RCTs and CCTs included in the review

Study

Population enrolled

Risk of bias

Likely bias

Generalisability

Bloom 1975

282

High

Reporting

Low

Ceyan 2001

1000

Moderate

Detection

Medium

Edees 1991

420

Moderate

Detection

Medium

Lerman 1981

502

Low

Detection

Medium

Peltola 1986

686

Low

Detection

High

Schwarz 1975

1481

High

Reporting

Low
Figuras y tablas -
Table 1. Summary of salient characteristic of RCTs and CCTs included in the review
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Table 2. Reporting of temp. in RCTs (MMR versus single components/placebo/do‐nothing)

Temp. increment (C)

Measurement site

Reporting frequency

Observation period

Reference

38.0 ‐ 38.4

Axilla

All episodes

21

Schwarz 1975

38.0 ‐ 38.4

Rectal

All episodes

21

Schwarz 1975

38.5 ‐ 38.9

Axilla

All episodes

21

Schwarz 1975

38.5 ‐ 38.9

Rectal

All episodes

21

Schwarz 1975

38.6 ‐ 39.5

Not reported

Mean number of episodes

21

Peltola 1986

39.0 ‐ 39.4

Axilla

All episodes

21

Schwarz 1975

39.0 ‐ 39.4

Rectal

All episodes

21

Schwarz 1975

39.5 ‐ 39.9

Axilla

All episodes

21

Schwarz 1975

39.5 ‐ 39.9

Rectal

All episodes

21

Schwarz 1975

40.0 ‐ 40.4

Rectal

All episodes

21

Schwarz 1975

Up to 38.5

Not reported

Mean number of episodes

21

Peltola 1986

> 1 C above normal

Not reported

First episode

21

Bloom 1975

> 38

Not reported

All episodes

42

Lerman 1981

Not reported

Not reported

First episode

21

Edees 1991

Up to 39.5

Not reported

Mean number of episodes

21

Peltola 1986
Figuras y tablas -
Table 2. Reporting of temp. in RCTs (MMR versus single components/placebo/do‐nothing)
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Table 3. Summary of salient characteristics of Cohort studies included in the review

Study

Population enrolled

Risk of bias

Likely bias

Generalisability

Beck 1989

196 *

High

Selection

Low

Benjamin 1992

5017

Moderate

Detection

Medium

Dunlop 1989

335

High

Selection

Low

Makino 1990

1638

High

Selection

Low

Miller 1989

12185

High

Reporting

Low

Robertson 1988

319

Moderate

Selection

Medium

Stokes 1971

966

High

Selection

Low

Swartz 1974

59

High

Selection

Low

Weibel 1980

135

High

Selection

Low

Madsen 2002

537303

Moderate

Detection

High

Fombonne 2001

263

High

Selection

Low

Makela 2002

561089

Moderate

Selection

Medium

Vestergaard 2004

537171

Low

Selection

High

DeStefano 2002

167240

Moderate

Selection

Medium

* The number enrolled is unclear
Figuras y tablas -
Table 3. Summary of salient characteristics of Cohort studies included in the review
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Table 4. Summary of salient characteristics of other study designs included in the review

Study

Design

Population

Risk of bias

Likely bias

Generalisability

Davis 2001

Case ‐ control

211

Low

‐

High

Black 1997

Case ‐ control

587

Low

‐

High

DeStefano 2004

Case ‐ control

2448

Moderate

Selection

Medium

Black 2003

Case ‐ control

139

Moderate

Selection

Medium

Smeeth 2004

Case ‐ control

10697

Moderate

Selection

Medium

Dourado 2000

Before and after

452,344

Moderate

Detection

Medium

Freeman 1993

Before and after

375

High

Attrition

Low

Jonville‐Bera 1996

Ecological

9,205,483*

Moderate

Selection

Medium

Taylor 1999

Case‐coverage

498

Moderate

Confounding

Medium

Park 2004

Case‐crossover

39

Moderate

Selection

Medium

Da Cuhna 2002

Before and after

845,889

Moderate

Selection

High

*Estimated number of vaccine doses
Figuras y tablas -
Table 4. Summary of salient characteristics of other study designs included in the review
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