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Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 1 Speed of processing.
Figuras y tablas -
Analysis 1.1

Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 1 Speed of processing.

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Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 2 Working Memory.
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Analysis 1.2

Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 2 Working Memory.

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Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 3 Free Recall.
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Analysis 1.3

Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 3 Free Recall.

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Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 4 Executive Function.
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Analysis 1.4

Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 4 Executive Function.

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Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 5 Verbal Ability.
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Analysis 1.5

Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 5 Verbal Ability.

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Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 6 Mood Measures.
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Analysis 1.6

Comparison 1 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women, Outcome 6 Mood Measures.

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Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 1 PLP.
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Analysis 2.1

Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 1 PLP.

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Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 2 Alpha‐EAST.
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Analysis 2.2

Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 2 Alpha‐EAST.

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Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 3 Associated Recognition Task.
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Analysis 2.3

Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 3 Associated Recognition Task.

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Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 4 Forget Scores.
Figuras y tablas -
Analysis 2.4

Comparison 2 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men, Outcome 4 Forget Scores.

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Comparison 1. 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Speed of processing Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 Boxes Test

1

33

Mean Difference (IV, Fixed, 95% CI)

1.57 [‐14.08, 17.22]

1.2 Digit‐Symbol Coding

1

33

Mean Difference (IV, Fixed, 95% CI)

3.89 [‐10.69, 18.47]

1.3 Symbol Search

1

33

Mean Difference (IV, Fixed, 95% CI)

0.06 [‐3.61, 3.73]

2 Working Memory Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 Digit Span‐Backwards

1

33

Mean Difference (IV, Fixed, 95% CI)

‐0.48 [‐2.73, 1.77]

2.2 Letter‐Number Sequencing

1

33

Mean Difference (IV, Fixed, 95% CI)

‐0.55 [‐3.45, 2.35]

3 Free Recall Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 Immediate Recall: RAVLT 1‐5

1

33

Mean Difference (IV, Fixed, 95% CI)

‐2.21 [‐11.40, 6.98]

3.2 Immediate Recall: RAVLT B

1

33

Mean Difference (IV, Fixed, 95% CI)

1.07 [‐0.63, 2.77]

3.3 Delayed Recall: RAVLT 6

1

33

Mean Difference (IV, Fixed, 95% CI)

‐0.32 [‐3.49, 2.85]

3.4 Delayed Recall: RAVLT 7

1

33

Mean Difference (IV, Fixed, 95% CI)

0.67 [‐212.77, 214.11]

3.5 Recognition: RAVLT A

1

33

Mean Difference (IV, Fixed, 95% CI)

0.28 [‐2.61, 3.17]

3.6 Recogntion ‐RAVLT B

1

33

Mean Difference (IV, Fixed, 95% CI)

1.23 [‐2.15, 4.61]

4 Executive Function Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 Stroop Test

1

33

Mean Difference (IV, Fixed, 95% CI)

‐0.06 [‐0.50, 0.38]

4.2 Uses of Objects

1

33

Mean Difference (IV, Fixed, 95% CI)

1.16 [‐3.92, 6.24]

4.3 Trail Making Test A

1

33

Mean Difference (IV, Fixed, 95% CI)

‐12.73 [‐29.05, 3.59]

4.4 Trail Making Test B

1

33

Mean Difference (IV, Fixed, 95% CI)

‐6.05 [‐46.55, 34.45]

4.5 Verbal Fluency ‐Initial Letter

1

33

Mean Difference (IV, Fixed, 95% CI)

‐2.08 [‐8.00, 5.84]

4.6 Verbal Fluency Excluded Letter

1

33

Mean Difference (IV, Fixed, 95% CI)

6.57 [‐2.97, 16.11]

5 Verbal Ability Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

5.1 Vocabulary

1

33

Mean Difference (IV, Fixed, 95% CI)

0.74 [‐6.02, 7.50]

5.2 Spot the Word

1

33

Mean Difference (IV, Fixed, 95% CI)

‐1.65 [‐14.14, 10.84]

6 Mood Measures Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

6.1 CESD

1

33

Mean Difference (IV, Fixed, 95% CI)

0.61 [‐4.78, 6.00]

6.2 POMS total

1

33

Mean Difference (IV, Fixed, 95% CI)

2.77 [‐12.28, 17.82]

6.3 Tension/Anxiety

1

33

Mean Difference (IV, Fixed, 95% CI)

0.20 [‐4.27, 4.67]

6.4 Depression/dejection

1

33

Mean Difference (IV, Fixed, 95% CI)

‐0.64 [‐4.78, 3.50]

6.5 Anger/hostility

1

33

Mean Difference (IV, Fixed, 95% CI)

‐1.28 [‐5.22, 2.66]

6.6 Vigour/Activity

1

33

Mean Difference (IV, Fixed, 95% CI)

‐2.35 [‐8.42, 3.72]

6.7 Fatigue/inertia

1

33

Mean Difference (IV, Fixed, 95% CI)

1.38 [‐2.16, 4.92]

6.8 Confusion/bewilderment

1

33

Mean Difference (IV, Fixed, 95% CI)

0.4 [‐1.90, 2.70]
Figuras y tablas -
Comparison 1. 75 mg Vitamin B6/day for five weeks vs placebo in healthy older women
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Comparison 2. 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 PLP Show forest plot

1

76

Mean Difference (IV, Fixed, 95% CI)

238.00 [211.58, 264.42]

2 Alpha‐EAST Show forest plot

1

76

Mean Difference (IV, Fixed, 95% CI)

0.43 [0.30, 0.56]

3 Associated Recognition Task Show forest plot

1

76

Mean Difference (IV, Fixed, 95% CI)

‐1.02 [‐2.40, 0.36]

4 Forget Scores Show forest plot

1

76

Mean Difference (IV, Fixed, 95% CI)

0.79 [‐0.34, 1.92]
Figuras y tablas -
Comparison 2. 20 mg vitamin B6/day for 12 weeks vs placebo in healthy older men
Ir a la tabla de la revisión