Intramuscular arteether for treating severe malaria

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Analysis 1.1

Comparison 1 Arteether versus quinine, Outcome 1 Death.

Analysis 1.2

Comparison 1 Arteether versus quinine, Outcome 2 Neurological complications at follow up.

Analysis 1.3

Comparison 1 Arteether versus quinine, Outcome 3 Time to regain consciousness (hours).

Analysis 1.4

Comparison 1 Arteether versus quinine, Outcome 4 Parasite clearance time (hours).

Analysis 1.5

Comparison 1 Arteether versus quinine, Outcome 5 Presence of parasites at day 7.

Analysis 1.6

Comparison 1 Arteether versus quinine, Outcome 6 Presence of parasites at day 28.

Analysis 1.7

Comparison 1 Arteether versus quinine, Outcome 7 Fever clearance time (hours).

Analysis 1.8

Comparison 1 Arteether versus quinine, Outcome 8 People with any adverse events.

Analysis 1.9

Comparison 1 Arteether versus quinine, Outcome 9 People with serious adverse events.

Table 1. Detailed search strategies

Search set	CIDG SR^a	CENTRAL	MEDLINE^b	EMBASE^b	NLM Gateway^b	Web Science Citation^b	LILACS^b
1	artemotil	artemotil	artemotil	artemotil	artemotil	artemotil	artemotil
2	arteether	arteether	artemotil	arteether	arteether	arteether	arteether
3	beta arteether	beta arteether	artemotil	beta arteether	beta arteether	beta arteether	1 or 2
4	alpha arteether	alpha arteether	alpha arteether	alpha arteether	alpha arteether	alpha arteether	—
5	artecef	artecef	artecef	artecef	artecef	artecef	—
6	E‐MAL	1 or 2 or 3 or 4 or 5	E‐MAL	E‐MAL	E‐MAL	E‐MAL	—
7	malaria	malaria	1 or 2 or 3 or 4 or 5 or 6	1 or 2 or 3 or 4 or 5 or 6	1 or 2 or 3 or 4 or 5 or 6	1 or 2 or 3 or 4 or 5 or 6	—
8	—	6 and 7	Exp MALARIA	Exp MALARIA	Exp MALARIA	Malaria	—
9	—	—	7 and 8	7 and 8	7 and 8	7 and 8	—
10	—	—	Limit to human	Limit to human	—	—	—
^aCochrane Infectious Diseases Group Specialized Register. ^bSearch terms used in combination with the search strategy for retrieving trials developed by The Cochrane Collaboration (Lefebvre 2008); upper case: MeSH or EMTREE heading; lower case: free text term.

Table 1. Detailed search strategies

Comparison 1. Arteether versus quinine

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death Show forest plot	2	194	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.43, 1.30]

2 Neurological complications at follow up Show forest plot	1	58	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [0.31, 4.46]

3 Time to regain consciousness (hours) Show forest plot	2	153	Mean Difference (IV, Fixed, 95% CI)	6.69 [‐3.19, 16.57]

4 Parasite clearance time (hours) Show forest plot	2	152	Mean Difference (IV, Fixed, 95% CI)	1.32 [‐6.48, 9.11]

5 Presence of parasites at day 7 Show forest plot	2	151	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.19, 1.67]

6 Presence of parasites at day 28 Show forest plot	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.39, 1.49]

7 Fever clearance time (hours) Show forest plot	2	146	Mean Difference (IV, Fixed, 95% CI)	5.10 [‐5.76, 15.95]

8 People with any adverse events Show forest plot	1	92	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.77, 1.22]

9 People with serious adverse events Show forest plot	1	102	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 8.00]

Comparison 1. Arteether versus quinine