Appendix 1. CCDANCTR update search ‐ Feb 2018

#1. antidepress* or anti‐depress* or "anti depress*" or MAOI* or RIMA* or “monoamine oxidase inhibit*” or ((serotonin or norepinephrine or noradrenaline or neurotransmitter* or dopamin*) NEAR (uptake or reuptake or re‐uptake or "re uptake")) or SSRI* or SNRI* or NARI* or SARI* or NDRI* or TCA* or tricyclic* or tetracyclic*
#2. Agomelatine or Alaproclate or Amoxapine or Amineptine or Amitriptylin* or Amitriptylinoxide or Atomoxetine or Befloxatone or Benactyzine or Binospirone or Brofaromine or (Bupropion or Amfebutamone) or Butriptyline or Caroxazone or Cianopramine or Cilobamine or Cimoxatone or Citalopram or (Chlorimipramin* or Clomipramin* or Chlomipramin* or Clomipramine) or Clorgyline or Clovoxamine or (CX157 or Tyrima) or Demexiptiline or Deprenyl or (Desipramine* or Pertofrane) or Desvenlafaxine or Dibenzepin or Diclofensine or Dimetacrin* or Dosulepin or Dothiepin or Doxepin or Duloxetine or Desvenlafaxine or DVS‐233
#3. Escitalopram or Etoperidone or Femoxetine or Fluotracen or Fluoxetine or Fluvoxamine or (Hyperforin or Hypericum or “St John*”) or Imipramin* or Iprindole or Iproniazid* or Ipsapirone or Isocarboxazid* or Levomilnacipran or Lofepramine* or (“Lu AA21004” or Vortioxetine) or "Lu AA24530" or (LY2216684 or Edivoxetine) or Maprotiline or Melitracen or Metapramine or Mianserin or Milnacipran or Minaprine or Mirtazapine or Moclobemide or Nefazodone or Nialamide or Nitroxazepine or Nomifensine or Norfenfluramine or Nortriptylin* or Noxiptilin*
#4. Opipramol or Oxaflozane or Paroxetine or Phenelzine or Pheniprazine or Pipofezine or Pirlindole or Pivagabine or Pizotyline or Propizepine or Protriptylin* or Quinupramine or Reboxetine or Rolipram or Scopolamine or Selegiline or Sertraline or Setiptiline or Teciptiline or Thozalinone or Tianeptin* or Toloxatone or Tranylcypromin* or Trazodone or Trimipramine or Venlafaxine or Viloxazine or Vilazodone or Viqualine or Zalospirone
#5. (#1 or #2 or #3 or #4 or #5)
#6. (depress* or dysthymi* or "adjustment disorder*" or "mood disorder*" or "affective disorder*" or "affective symptoms") AND (postpartum or "post partum" or post‐partum or postnatal or "post natal" or post‐natal or puerper*)
#7. (#5 and #6)

Appendix 2. Earlier searches conducted to June 2007

Earlier searches, conducted for the first version of this review used the following search strategies (to 11‐June‐2007):

1. TheCCDANCTR‐Studies Register was searched using the following controlled search terms:

Diagnosis = Depression, Postpartum
AND
Intervention = (Antidepress* or "Monoamine Oxidase Inhibitors" or "Selective Serotonin Reuptake Inhibitors" or "Tricyclic Drugs" or Acetylcarnitine or Alaproclate or Amersergide or Amiflamine or Amineptine or Amitriptyline or Amoxapine or Befloxatone or Benactyzine or Brofaromine or Bupropion or Butriptyline or Caroxazone or Chlorpoxiten or Cilosamine or Cimoxatone or Citalopram or Clomipramine or Clorgyline or Clorimipramine or Clovoxamine or Deanol or Demexiptiline or Deprenyl or Desipramine or Dibenzipin or Diclofensine or Dothiepin or Doxepin or Duloxetine or Escitalopram or Etoperidone or Femoxetine or Fluotracen or Fluoxetine or Fluparoxan or Fluvoxamine or Idazoxan or Imipramine or Iprindole or Iproniazid or isocarboxazid or Litoxetine or Lofepramine or Maprotiline or Medifoxamine or Melitracen or Metapramine or Mianserin or Milnacipran or Minaprine or Mirtazapine or Moclobemide or Nefazodone or Nialamide or Nomifensine or Nortriptyline or Noxiptiline or Opipramol or Oxaflozane or Oxaprotiline or Pargyline or Paroxetine or Phenelzine or Piribedil or Pirlindole or Pivagabine or Prosulpride or Protriptyline or Quinupramine or Reboxetine or Rolipram or Sertraline or Setiptiline or SSRI* or Teniloxine or Tetrindole or Thiazesim or Thozalinone or Tianeptine or Toloxatone or Tomoxetine or Tranylcypromine or Trazodone or Trimipramine or Venlafaxine or Viloxazine or Viqualine or Zimeldine)

2. The CCDANCTR‐References Register was searched using a more sensitive set of free‐text terms to identify additional untagged/uncoded reports of RCTs:

Keyword = Depress* or Dysthymi* or "Adjustment Disorder*" or "Mood Disorder*" or "Affective Disorder*" or "Affective Symptoms"
AND
Free‐text = Postpartum or "post partum" or post‐partum or Postnatal or "post natal" or post‐natal
AND
Free‐text = Antidepress* or "Monoamine Oxidase Inhibitors" or "Selective Serotonin Reuptake Inhibitors" or SSRI* or "Tricyclic Drugs" or Acetylcarnitin* or Alaproclat* or Amersergid* or Amiflamin* or Amineptin* or Amitriptylin* or Amoxapin* or Befloxaton* or Benactyzin* or Brofaromin* or Bupropion or Butriptylin* or Caroxazon* or Chlorpoxiten or Cilosamin* or Cimoxaton* or Citalopram or Clomipramin* or Clorgylin* or Clorimipramin* or Clovoxamin* or Deanol or Demexiptilin* or Deprenyl or Desipramin* or Dibenzipin or Diclofensin* or Dothiepin or Doxepin or Duloxetin* or Escitalopram or Etoperidon* or Femoxetin* or Fluotracen or Fluoxetin* or Fluparoxan or Fluvoxamin* or Idazoxan or Imipramin* or Iprindol* or Iproniazid or isocarboxazid or Litoxetin* or Lofepramin* or Maprotilin* or Medifoxamin* or Melitracen or Metapramin* or Mianserin or Milnacipran or Minaprin* or Mirtazapin* or Moclobemid* or Nefazodon* or Nialamid* or Nomifensin* or Nortriptylin* or Noxiptilin* or Opipramol or Oxaflozan* or Oxaprotilin* or Pargylin* or Paroxetin* or Phenelzin* or Piribedil or Pirlindol* or Pivagabin* or Prosulprid* or Protriptylin* or Quinupramin* or Reboxetin* or Rolipram or Sertralin* or Setiptilin* or Teniloxin* or Tetrindol* or Thiazesim or Thozalinon* or Tianeptin* or Toloxaton* or Tomoxetin* or Tranylcypromin* or Trazodon* or Trimipramin* or Venlafaxin* or Viloxazin* or Viqualin* or Zimeldin*

3. The Cochrane Central Register of Controlled Trials (CENTRAL) and the specialised register of the Cochrane Pregnancy and Childbirth Review Group were searched with the following terms: Postnatal or postpartum or puerper*

4. Searches for grey literature included:

• The HSRProj in the National Library of Medicine, Washington D.C was checked for unpublished trials.

• References from MIDIRS Midwifery Database was searched.

• Current Controlled Trials web site: http://www.controlled trials.com/terms2.cfm was examined for ongoing studies.

• The Science Citation Index was checked for references to all included studies.

• Conference proceedings were examined where possible (details available from authors on request).

5. Reference lists
The reference lists of all included studies were checked to identify additional studies missed from the original electronic searches (for example unpublished or in‐press citations). Relevant book chapters and their bibliographies were searched (details available from authors on request).

6. Correspondence
Pharmaceutical companies were contacted directly for any relevant unpublished data.
Contact was made with authors of identified trials and with experts in the field including a search for non‐English material (Professor L Appleby, Professor P Boyce, Dr T Brugha, Dr L Cohen, Dr N Glangeaud, Dr S Glasser, Dr M Marks, Dr A Wieck, Professor K Wisner).
Contact with the Marcé Society through the newsletter was made.
Self help groups were contacted (the National Childbirth Trust (NCT), The Association for Postnatal Illness, Postnatal Distress Association of Ireland, Postpartum Support International (PSI) and PaNDA).

Appendix 3. Update searches conducted to February 2018

Database: CENTRAL

Host: Wiley

Data Parameters: Issue 1 of 12, January 2018

Date searched: Tuesday, February 13^th 2018

Searched by: Chris Cooper

Hits: 18

Search strategy:

ID Search Hits

#1 (postpartum or post partum or postnatal or post natal or puerper*) 9779

#2 MeSH descriptor: [Antidepressive Agents] explode all trees 5750

#3 (antidepress* or anti depress* or MAOI* or RIMA* or monoamine oxidase inhibit* or ((serotonin or norepinephrine or noradrenaline or nor epinephrine or nor adrenaline or neurotransmitt* or dopamine*) and (uptake or reuptake or "re‐uptake")) or noradrenerg* or antiadrenergic or anti adrenergic or SSRI* or SNRI* or NARI* or SARI* NDRI* or TCA* or tricyclic* or tetracyclic* or heterocyclic* or psychotropic*) .mp. 1080

#4 (Agomelatine or Alaproclate or Amoxapine or Amineptine or Amitriptylin* or Amitriptylinoxide or Atomoxetine or Befloxatone or Benactyzine or Binospirone or Brofaromine or Bupropion or Amfebutamone or Butriptyline or Caroxazone or Cianopramine or Cilobamine or Cimoxatone or Citalopram or Chlorimipramin* or Clomipramin* or Chlomipramin* or Clomipramine or Clorgyline or Clovoxamine or CX157 or Tyrima or Demexiptiline or Deprenyl or Desipramine* or Pertofrane or Desvenlafaxine or Dibenzepin or Diclofensine or Dimetacrin* or Dosulepin or Dothiepin or Doxepin or Duloxetine or Desvenlafaxine or DVS‐233 or Escitalopram or Esmirtazapine or Etoperidone or Femoxetine or Fluotracen or Fluoxetine or Fluvoxamine or Hyperforin or Hypericum or "St John*" or Imipramin* or Iprindole or Iproniazid* or Ipsapirone or Isocarboxazid* or Levomilnacipran or Lofepramine* or "Lu AA21004" or Vortioxetine or "Lu AA24530" or "LY2216684" or Edivoxetine or Maprotiline or Melitracen or Metapramine or Mianserin or Milnacipran or Minaprine or Mirtazapine or Moclobemide or Nefazodone or Nialamide or Nitroxazepine or Nomifensine or Norfenfluramine or Nortriptylin* or Noxiptilin* or Opipramol or Oxaflozane or Paroxetine or Phenelzine or Pheniprazine or Pipofezine or Pirlindole or Pivagabine or Pizotyline or Propizepine or Protriptylin* or Quinupramine or Reboxetine or Rolipram or Scopolamine or Selegiline or Sertraline or Setiptiline or Teciptiline or Thozalinone or Tianeptin* or Toloxatone or Tranylcypromin* or Trazodone or Trimipramine or Venlafaxine or Viloxazine or Vilazodone or Viqualine or Zalospirone) 22191

#5 #2 or #3 or #4 24723

#6 #1 and #5 252

Notes: CENTRAL only = 18 records in date range 2016‐current

File: GS51 CENTRAL18.txt

Databases: Ovid MEDLINE(R) Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)

Host: OVID

Data Parameters: 1946 to Present

Date Searched: Tuesday, February 13^th 2018

Searched by: Chris

Hits: 28

Search strategy:

Search Strategy:

Notes: N/A

File: GS51MEDLINE28.txt

Database: Embase

Host: OVID

Data Parameters: 1974 to 2018 February 12

Date searched: Tuesday, February 13^th 2018

Searched by: Chris Cooper

Hits: 50

Search strategy:

Search Strategy:

Notes: N/A

File: GS51 Embase50.txt

Database: PscyINFO

Host: OVID

Data Parameters: 1806 to February Week 1 2018

Date searched: Tuesday, February 13^th 2018

Searched by: Chris Cooper

Hits: 44

Search strategy:

Notes: N/A

File: GS51 PsycINFO44.txt