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Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 1 Cough frequency/24 hrs.
Figuras y tablas -
Analysis 1.1

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 1 Cough frequency/24 hrs.

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 2 Symptom score (parent completed).
Figuras y tablas -
Analysis 1.2

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 2 Symptom score (parent completed).

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 3 Symptom score (child completed).
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Analysis 1.3

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 3 Symptom score (child completed).

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 4 C5 (lowest concentration of capsaicin required to stimulate 5 or more coughs).
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Analysis 1.4

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 4 C5 (lowest concentration of capsaicin required to stimulate 5 or more coughs).

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 5 Cth (lowest concentration of capsaicin required to stimulate 2 or more coughs).
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Analysis 1.5

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 5 Cth (lowest concentration of capsaicin required to stimulate 2 or more coughs).

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 6 Compliance (N deemed 'compliant' based upon cannister weight).
Figuras y tablas -
Analysis 1.6

Comparison 1 Low‐dose maintenance inhaled corticosteroid versus placebo, Outcome 6 Compliance (N deemed 'compliant' based upon cannister weight).

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 1 More than 75% improvement on days 3‐4.
Figuras y tablas -
Analysis 2.1

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 1 More than 75% improvement on days 3‐4.

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 2 More than 75% improvement on days 15‐16.
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Analysis 2.2

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 2 More than 75% improvement on days 15‐16.

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 3 More than 75% improvement if positive skin prick test is positive.
Figuras y tablas -
Analysis 2.3

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 3 More than 75% improvement if positive skin prick test is positive.

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 4 More than 75% improvement if IgE more than 100 Ku/I.
Figuras y tablas -
Analysis 2.4

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 4 More than 75% improvement if IgE more than 100 Ku/I.

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 5 More than 75% better if positive family history of atopy.
Figuras y tablas -
Analysis 2.5

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 5 More than 75% better if positive family history of atopy.

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 6 Compliance (N deemed 'compliant' based on canister weight).
Figuras y tablas -
Analysis 2.6

Comparison 2 High‐dose short term inhaled corticosteroids versus placebo, Outcome 6 Compliance (N deemed 'compliant' based on canister weight).

Table 1. Search strategies

Database searched

Terms used

Central

#1.ADRENAL CORTEX HORMONES (MeSH); #2.(steroid* or corticosteroid* or glucocorticosteroid* or glucocorticoid* or corticoid* or corticotherapy); #3.(beclomethasone or qvar or becodisk* or becotide or asmabec or becloforte or beclazone or filair or pulvinal or cyclohaler* or cyclocap* or aerobec or ventide or budesonide or pulmicort or (symbicort next ot next turbohaler) or respule* or oxis or fluticasone or accuhaler* or diskhaler* or evohaler* or nebule* or seretide); #4.(#1 or #2 or #3); #5.COUGH (MeSH); #6.cough*; #7.(#5 or #6); #8.(#4 and #7)
#9.NEBULIZERS AND VAPORIZERS (MeSH); #10.(aerosol* or inhal* or atomi* or nebuli* or volatili*); #11.(#9 or #10); #12.(#8 and #11)

Medline

#1. exp Adrenal Cortex Hormones/; #2. (steroid$ or corticosteroid$ or glucocorticosteroid$ or glucocorticoid$ or corticoid$ or corticotherapy).mp. [mp=title, abstract, subject headings, drug trade name, original title, device manufacturer, drug manufacturer name]
#3. (Beclomethasone or Qvar or Becodisks or Becotide or Asmabec or Becloforte or Beclazone or Filair or Pulvinal or Cyclohaler or Cyclocaps or Aerobec or Ventide or budesonide or pulmicort or symbicort or turbohaler or respules or oxis or fluticasone or accuhaler or diskhaler or evohaler or nebules or seretide).mp. [mp=title, abstract, subject headings, drug trade name, original title, device manufacturer, drug manufacturer name]; #4. 1 or 2 or 3; #5. exp Cough/; #6. cough$.mp. [mp=title, abstract, subject headings, drug trade name, original title, device manufacturer, drug manufacturer name]; #7. 5 or 6; #8. 4 and 7

Embase

#1. exp corticosteroid/ or exp glucocorticoid/; #2. (steroid$ or corticosteroid$ or glucocorticosteroid$ or glucocorticoid$ or corticoid$ or corticotherapy).mp. [mp=title, abstract, subject headings, drug trade name, original title, device manufacturer, drug manufacturer name]
#3. (Beclomethasone or Qvar or Becodisks or Becotide or Asmabec or Becloforte or Beclazone or Filair or Pulvinal or Cyclohaler or Cyclocaps or Aerobec or Ventide or budesonide or pulmicort or symbicort or turbohaler or respules or oxis or fluticasone or accuhaler or diskhaler or evohaler or nebules or seretide).mp. [mp=title, abstract, subject headings, drug trade name, original title, device manufacturer, drug manufacturer name]; #4. 1 or 2 or 3; #5. exp Coughing/; #6. cough$.mp. [mp=title, abstract, subject headings, drug trade name, original title, device manufacturer, drug manufacturer name]; #7. 5 or 6; #8. 4 and 7

Figuras y tablas -
Table 1. Search strategies
Comparison 1. Low‐dose maintenance inhaled corticosteroid versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Cough frequency/24 hrs Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2 Symptom score (parent completed) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Symptom score (child completed) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4 C5 (lowest concentration of capsaicin required to stimulate 5 or more coughs) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5 Cth (lowest concentration of capsaicin required to stimulate 2 or more coughs) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6 Compliance (N deemed 'compliant' based upon cannister weight) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 1. Low‐dose maintenance inhaled corticosteroid versus placebo
Comparison 2. High‐dose short term inhaled corticosteroids versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 More than 75% improvement on days 3‐4 Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 More than 75% improvement on days 15‐16 Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 More than 75% improvement if positive skin prick test is positive Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 More than 75% improvement if IgE more than 100 Ku/I Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 More than 75% better if positive family history of atopy Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Compliance (N deemed 'compliant' based on canister weight) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 2. High‐dose short term inhaled corticosteroids versus placebo