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Comparison 1 Inhaled tobramycin versus placebo, Outcome 1 Positive respiratory culture for P. aeruginosa (Gibson 2003).
Figuras y tablas -
Analysis 1.1

Comparison 1 Inhaled tobramycin versus placebo, Outcome 1 Positive respiratory culture for P. aeruginosa (Gibson 2003).

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Comparison 1 Inhaled tobramycin versus placebo, Outcome 2 Positive respiratory culture for P. aeruginosa (Wiesemann 1998).
Figuras y tablas -
Analysis 1.2

Comparison 1 Inhaled tobramycin versus placebo, Outcome 2 Positive respiratory culture for P. aeruginosa (Wiesemann 1998).

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Comparison 1 Inhaled tobramycin versus placebo, Outcome 3 Positive respiratory culture for P. aeruginosa (combined available case analysis).
Figuras y tablas -
Analysis 1.3

Comparison 1 Inhaled tobramycin versus placebo, Outcome 3 Positive respiratory culture for P. aeruginosa (combined available case analysis).

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Comparison 1 Inhaled tobramycin versus placebo, Outcome 4 Positive respiratory culture for P. aeruginosa (combined) ‐ best case.
Figuras y tablas -
Analysis 1.4

Comparison 1 Inhaled tobramycin versus placebo, Outcome 4 Positive respiratory culture for P. aeruginosa (combined) ‐ best case.

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Comparison 1 Inhaled tobramycin versus placebo, Outcome 5 Positive respiratory culture for P. aeruginosa (combined) ‐ worst case.
Figuras y tablas -
Analysis 1.5

Comparison 1 Inhaled tobramycin versus placebo, Outcome 5 Positive respiratory culture for P. aeruginosa (combined) ‐ worst case.

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Comparison 1 Inhaled tobramycin versus placebo, Outcome 6 Change in weight from baseline.
Figuras y tablas -
Analysis 1.6

Comparison 1 Inhaled tobramycin versus placebo, Outcome 6 Change in weight from baseline.

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Comparison 1 Inhaled tobramycin versus placebo, Outcome 7 Adverse events.
Figuras y tablas -
Analysis 1.7

Comparison 1 Inhaled tobramycin versus placebo, Outcome 7 Adverse events.

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Comparison 1 Inhaled tobramycin versus placebo, Outcome 8 Change in modified Shwachmann score from baseline.
Figuras y tablas -
Analysis 1.8

Comparison 1 Inhaled tobramycin versus placebo, Outcome 8 Change in modified Shwachmann score from baseline.

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Comparison 2 Oral ciprofloxacin and inhaled colistin versus no treatment, Outcome 1 Proportion colonised with P. aeruginosa.
Figuras y tablas -
Analysis 2.1

Comparison 2 Oral ciprofloxacin and inhaled colistin versus no treatment, Outcome 1 Proportion colonised with P. aeruginosa.

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Comparison 3 Oral ciprofloxacin and inhaled colistin versus inhaled tobramycin, Outcome 1 Positive respiratory culture for P.aeruginosa.
Figuras y tablas -
Analysis 3.1

Comparison 3 Oral ciprofloxacin and inhaled colistin versus inhaled tobramycin, Outcome 1 Positive respiratory culture for P.aeruginosa.

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Comparison 1. Inhaled tobramycin versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Positive respiratory culture for P. aeruginosa (Gibson 2003) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 At 1 month

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 At 2 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Positive respiratory culture for P. aeruginosa (Wiesemann 1998) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2.1 At 1 month

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 At 2 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.3 At 3 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.4 At 6 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.5 At 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Positive respiratory culture for P. aeruginosa (combined available case analysis) Show forest plot

2

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

3.1 At 1 month

2

38

Odds Ratio (M‐H, Fixed, 95% CI)

0.06 [0.01, 0.33]

3.2 At 2 months

2

38

Odds Ratio (M‐H, Fixed, 95% CI)

0.15 [0.03, 0.65]

4 Positive respiratory culture for P. aeruginosa (combined) ‐ best case Show forest plot

2

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

4.1 At 1 month

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.06 [0.01, 0.30]

4.2 At 2 months

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.14 [0.03, 0.60]

4.3 At 3 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.14 [0.02, 1.16]

4.4 At 6 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.04 [0.00, 0.48]

4.5 At 12 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.01 [0.00, 0.26]

5 Positive respiratory culture for P. aeruginosa (combined) ‐ worst case Show forest plot

2

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5.1 At 1 month

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.08 [0.02, 0.38]

5.2 At 2 months

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.18 [0.04, 0.73]

5.3 At 3 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.36 [0.05, 2.77]

5.4 At 6 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.16 [0.01, 1.83]

5.5 At 12 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.36 [0.05, 2.77]

6 Change in weight from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.2 At 2 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Adverse events Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7.1 Cough

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Change in modified Shwachmann score from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.2 At 2 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Inhaled tobramycin versus placebo
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Comparison 2. Oral ciprofloxacin and inhaled colistin versus no treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Proportion colonised with P. aeruginosa Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 At 3 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 At 6 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.3 At 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.4 At 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 2. Oral ciprofloxacin and inhaled colistin versus no treatment
Ir a la tabla de la revisión
Comparison 3. Oral ciprofloxacin and inhaled colistin versus inhaled tobramycin

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Positive respiratory culture for P.aeruginosa Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 At 6 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 3. Oral ciprofloxacin and inhaled colistin versus inhaled tobramycin
Ir a la tabla de la revisión