1 Failure to respond ‐ HDRS (‐50%) Show forest plot

21

2040

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.95 [0.80, 1.14]

1.1 Fluoxetine vs Amitriptyline

9

700

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.02 [0.74, 1.38]

1.2 Fluoxetine vs Clomipramine

1

94

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.64 [0.28, 1.44]

1.3 Fluoxetine vs Desipramine

1

58

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.11 [0.38, 3.25]

1.4 Fluoxetine vs Dothiepine

2

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.09 [1.08, 4.05]

1.5 Fluoxetine vs Doxepine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.0 [0.29, 3.49]

1.6 Fluoxetine vs Imipramine

6

821

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.80 [0.61, 1.06]

1.7 Fluoxetine vs Lofepramine

1

183

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.99 [0.55, 1.77]

2 End‐point score on HDRS Show forest plot

46

3224

Std. Mean Difference (IV, Random, 95% CI)

0.07 [‐0.06, 0.20]

2.1 Fluoxetine vs Amiptriptyline

17

958

Std. Mean Difference (IV, Random, 95% CI)

0.12 [‐0.07, 0.31]

2.2 Fluoxetine vs Clomipramine

5

372

Std. Mean Difference (IV, Random, 95% CI)

‐0.10 [‐0.31, 0.10]

2.3 Fluoxetine vs Desipramine

3

121

Std. Mean Difference (IV, Random, 95% CI)

1.25 [‐1.28, 3.78]

2.4 Fluoxetine vs Dothiepine

4

266

Std. Mean Difference (IV, Random, 95% CI)

0.16 [‐0.27, 0.59]

2.5 Fluoxetine vs Imipramine

13

1123

Std. Mean Difference (IV, Random, 95% CI)

‐0.03 [‐0.23, 0.16]

2.6 Fluoxetine vs Lofepramine

1

183

Std. Mean Difference (IV, Random, 95% CI)

0.13 [‐0.16, 0.42]

2.7 Fluoxetine vs Nomifensine

1

28

Std. Mean Difference (IV, Random, 95% CI)

‐0.37 [‐1.12, 0.38]

2.8 Fluoxetine vs Nortriptyline

1

154

Std. Mean Difference (IV, Random, 95% CI)

‐0.12 [‐0.44, 0.20]

2.9 Fluoxetine vs Trimipramine

1

19

Std. Mean Difference (IV, Random, 95% CI)

0.47 [‐0.44, 1.39]

3 Failure to complete ‐ Total Show forest plot

47

4136

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.78 [0.68, 0.89]

3.1 Fluoxetine vs Amitriptyline

16

1012

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.64 [0.47, 0.85]

3.2 Fluoxetine vs Clomipramine

2

263

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.66 [0.38, 1.14]

3.3 Fluoxetine vs Desipramine

2

104

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.45 [0.17, 1.19]

3.4 Fluoxetine vs Dothiepine

5

478

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.44 [0.98, 2.12]

3.5 Fluoxetine vs Doxepine

4

323

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.81 [0.50, 1.31]

3.6 Fluoxetine vs Imipramine

13

1285

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.79 [0.63, 0.99]

3.7 Fluoxetine vs Lofepramine

1

183

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.51 [0.25, 1.03]

3.8 Fluoxetine vs Nomifensine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.62 [0.83, 25.62]

3.9 Fluoxetine vs Nortriptyline

3

448

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.68 [0.45, 1.03]

4 Failure to complete ‐ Inefficacy Show forest plot

32

2894

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.28 [0.96, 1.69]

4.1 Fluoxetine vs Amitriptyline

11

758

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.99 [0.49, 2.02]

4.2 Fluoxetine vs Clomipramine

1

120

Peto Odds Ratio (Peto, Fixed, 95% CI)

7.65 [0.78, 74.93]

4.3 Fluoxetine vs Desipramine

2

104

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.02 [0.19, 5.30]

4.4 Fluoxetine vs Dothiepine

3

271

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.35 [0.52, 3.49]

4.5 Fluoxetine vs Doxepine

3

283

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.70 [0.62, 4.67]

4.6 Fluoxetine vs Imipramine

11

1153

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.34 [0.94, 1.93]

4.7 Fluoxetine vs Nortriptyline

1

205

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.41 [0.09, 1.84]

5 Failure to complete ‐ Side Effects Show forest plot

39

3630

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.54 [0.45, 0.64]

5.1 Fluoxetine vs Amitriptyline

14

961

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.40 [0.27, 0.61]

5.2 Fluoxetine vs Clomipramine

2

263

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.34 [0.15, 0.78]

5.3 Fluoxetine vs Desipramine

2

104

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.25 [0.07, 0.92]

5.4 Fluoxetine vs Dothiepine

5

478

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.58 [0.90, 2.78]

5.5 Fluoxetine vs Doxepine

3

283

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.80 [0.47, 1.37]

5.6 Fluoxetine vs Imipramine

11

1153

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.44 [0.33, 0.58]

5.7 Fluoxetine vs Lofepramine

1

183

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.24 [0.05, 1.07]

5.8 Fluoxetine vs Nortriptyline

1

205

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.86 [0.42, 1.77]

1 Failure to respond ‐ HDRS (‐50%) Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 Fluoxetine vs Maprotiline

2

163

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.92 [0.92, 3.98]

1.2 Fluoxetine vs Mianserin

1

53

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.81 [0.27, 2.36]

2 End‐point score on HDRS Show forest plot

8

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

2.6 Fluoxetine vs Maprotiline

5

433

Std. Mean Difference (IV, Random, 95% CI)

0.04 [‐0.15, 0.23]

2.7 Fluoxetine vs Mianserin

3

128

Std. Mean Difference (IV, Random, 95% CI)

0.43 [‐0.38, 1.23]

3 Failure to complete ‐ Total Show forest plot

6

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 Fluoxetine vs Maprotiline

4

351

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.75 [0.93, 3.30]

3.2 Fluoxetine vs Mianserin

2

93

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.67 [0.27, 1.70]

4 Failure to complete ‐ Inefficacy Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 Fluoxetine vs Maprotiline

3

209

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.01 [0.73, 12.41]

4.2 Fluoxetine vs Mianserin

1

53

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.18 [0.40, 11.74]

5 Failure to complete ‐ Side Effects Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 Fluoxetine vs Maprotiline

3

209

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.54 [0.16, 1.83]

5.2 Fluoxetine vs Mianserin

1

53

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.04 [0.24, 4.64]

1 Failure to respond ‐ HDRS (‐50%) Show forest plot

14

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 Fluoxetine vs Fluvoxamine

1

177

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.95 [0.52, 1.74]

1.2 Fluoxetine vs Paroxetine

8

960

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.25 [0.96, 1.63]

1.3 Fluoxetine vs Sertraline

7

1266

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.40 [1.11, 1.76]

2 End‐point score on HDRS Show forest plot

17

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

2.1 Fluoxetine vs Citalopram

2

610

Std. Mean Difference (IV, Random, 95% CI)

0.05 [‐0.10, 0.21]

2.2 Fluoxetine vs Paroxetine

9

1162

Std. Mean Difference (IV, Random, 95% CI)

‐0.01 [‐0.36, 0.35]

2.3 Fluoxetine vs Sertraline

8

1238

Std. Mean Difference (IV, Random, 95% CI)

0.10 [‐0.01, 0.21]

3 Failure to complete ‐ Total Show forest plot

20

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 Fluoxetine vs Citalopram

2

673

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.87 [0.59, 1.27]

3.2 Fluoxetine vs Fluvoxamine

2

284

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.71 [0.37, 1.36]

3.3 Fluoxetine vs Paroxetine

8

1096

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.96 [0.74, 1.25]

3.4 Fluoxetine vs Sertraline

10

1669

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.23 [0.98, 1.55]

4 Failure to complete ‐ Inefficacy Show forest plot

8

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 Fluoxetine vs Citalopram

2

673

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.90 [0.49, 1.65]

4.2 Fluoxetine vs Paroxetine

2

253

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.85 [0.25, 2.84]

4.3 Fluoxetine vs Sertraline

6

1134

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.07 [0.67, 1.70]

5 Failure to complete ‐ Side Effects Show forest plot

18

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 Fluoxetine vs Citalopram

2

673

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.57 [0.30, 1.09]

5.2 Fluoxetine vs Fluvoxamine

1

100

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.04 [0.14, 7.63]

5.3 Fluoxetine vs Paroxetine

7

757

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.83 [0.52, 1.34]

5.4 Fluoxetine vs Sertraline

10

1669

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.23 [0.91, 1.66]

1 Failure to respond ‐ HDRS (‐50%) Show forest plot

33

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 Fluoxetine vs Amineptine

1

63

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.38 [0.14, 1.04]

1.2 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.19 [0.58, 2.43]

1.3 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.41 [0.61, 3.24]

1.4 Fluoxetine vs Hypericum

3

469

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.34 [0.93, 1.94]

1.5 Fluoxetine vs Milnacipram

1

300

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.15 [0.71, 1.86]

1.6 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.64 [1.01, 2.65]

1.7 Fluoxetine vs Moclobemide

7

721

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.27 [0.94, 1.71]

1.8 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.40 [0.28, 7.02]

1.9 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.55 [0.24, 1.26]

1.10 Fluoxetine vs Reboxetine

2

421

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.93 [0.63, 1.37]

1.11 Fluoxetine vs Tianeptine

1

387

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.12 [0.75, 1.66]

1.12 Fluoxetine vs Trazodone

3

110

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.55 [0.26, 1.16]

1.13 Fluoxetine vs Venlafaxine

9

1891

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.40 [1.15, 1.70]

2 End‐point score on HDRS Show forest plot

33

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

2.1 Fluoxetine vs ABT‐200

1

141

Std. Mean Difference (IV, Random, 95% CI)

‐1.85 [‐2.25, ‐1.45]

2.2 Fluoxetine vs Amisulpride

1

268

Std. Mean Difference (IV, Random, 95% CI)

0.17 [‐0.07, 0.41]

2.3 Fluoxetine vs Hypericum

3

448

Std. Mean Difference (IV, Random, 95% CI)

0.11 [‐0.08, 0.29]

2.4 Fluoxetine vs Milnacipram

1

149

Std. Mean Difference (IV, Random, 95% CI)

‐0.38 [‐0.71, ‐0.06]

2.5 Fluoxetine vs Moclobemide

6

540

Std. Mean Difference (IV, Random, 95% CI)

0.13 [‐0.04, 0.30]

2.6 Fluoxetine vs Nefazodone

3

238

Std. Mean Difference (IV, Random, 95% CI)

‐0.06 [‐0.32, 0.19]

2.7 Fluoxetine vs Phenelzine

1

40

Std. Mean Difference (IV, Random, 95% CI)

‐0.05 [‐0.67, 0.57]

2.8 Fluoxetine vs Reboxetine

1

168

Std. Mean Difference (IV, Random, 95% CI)

0.15 [‐0.16, 0.45]

2.9 Fluoxetine vs Tianeptine

3

730

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.40, 0.10]

2.10 Fluoxetine vs Trazodone

3

90

Std. Mean Difference (IV, Random, 95% CI)

‐0.06 [‐0.65, 0.53]

2.11 Fluoxetine vs Venlafaxine

10

1831

Std. Mean Difference (IV, Random, 95% CI)

0.11 [0.00, 0.23]

3 Failure to complete ‐ Total Show forest plot

42

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 Fluoxetine vs ABT‐200

1

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.21 [0.10, 0.41]

3.2 Fluoxetine vs Amineptine

2

232

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.71 [0.37, 1.38]

3.3 Fluoxetine vs Amisulpride

1

281

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.39 [0.81, 2.37]

3.4 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.15 [0.52, 2.52]

3.5 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.09 [0.46, 2.60]

3.6 Fluoxetine vs Hypericum

3

471

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.40 [0.68, 2.89]

3.7 Fluoxetine vs Milnacipram

2

490

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.93 [0.63, 1.38]

3.8 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.86 [0.52, 1.44]

3.9 Fluoxetine vs Moclobemide

7

721

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.01 [0.70, 1.45]

3.10 Fluoxetine vs Nefazodone

2

118

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.39 [0.14, 1.06]

3.11 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.13 [0.01, 2.13]

3.12 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.20 [0.08, 0.47]

3.13 Fluoxetine vs Reboxetine

2

421

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.61 [0.40, 0.94]

3.14 Fluoxetine vs Tianeptine

3

830

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.96 [0.69, 1.33]

3.15 Fluoxetine vs Trazodone

3

110

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.46 [0.21, 1.03]

3.16 Fluoxetine vs Venlafaxine

10

2036

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.94 [0.76, 1.15]

4 Failure to complete ‐ Inefficacy Show forest plot

38

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 Fluoxetine vs ABT‐200

1

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.29 [0.05, 1.72]

4.2 Fluoxetine vs Amineptine

1

63

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.04 [0.20, 5.49]

4.3 Fluoxetine vs Amisulpride

1

281

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.16 [0.44, 3.09]

4.4 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.74 [0.38, 19.95]

4.5 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.81 [0.56, 25.87]

4.6 Fluoxetine vs Hypericum

2

401

Peto Odds Ratio (Peto, Fixed, 95% CI)

6.88 [0.43, 111.26]

4.7 Fluoxetine vs Milnacipram

2

490

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.19 [0.69, 2.02]

4.8 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.28 [0.64, 8.10]

4.9 Fluoxetine vs Moclobemide

6

679

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.69 [0.35, 1.37]

4.10 Fluoxetine vs Nefazodone

2

118

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.13 [0.01, 2.15]

4.11 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.12 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.54 [0.08, 3.57]

4.13 Fluoxetine vs Reboxetine

2

421

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.96 [0.49, 1.87]

4.14 Fluoxetine vs Tianeptine

3

830

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.81 [0.41, 1.60]

4.15 Fluoxetine vs Trazodone

2

70

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.23 [0.04, 1.19]

4.16 Fluoxetine vs Venlafaxine

10

2036

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.32 [0.87, 1.99]

5 Failure to complete ‐ Side Effects Show forest plot

42

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 Fluoxetine vs ABT‐200

1

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.14 [0.06, 0.31]

5.2 Fluoxetine vs Amineptine

2

232

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.61 [0.22, 1.69]

5.3 Fluoxetine vs Amisulpride

1

281

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.77 [0.33, 1.81]

5.4 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.64 [0.18, 2.31]

5.5 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.38 [0.08, 1.78]

5.6 Fluoxetine vs Hypericum

3

471

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.32 [0.52, 3.35]

5.7 Fluoxetine vs Milnacipram

2

490

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.46 [0.75, 2.84]

5.8 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.82 [0.41, 1.65]

5.9 Fluoxetine vs Moclobemide

7

721

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.07 [0.64, 1.80]

5.10 Fluoxetine vs Nefazodone

3

243

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.73 [0.30, 1.76]

5.11 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.14 [0.00, 6.82]

5.12 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.19 [0.07, 0.51]

5.13 Fluoxetine vs Reboxetine

1

168

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.57 [0.20, 1.63]

5.14 Fluoxetine vs Tianeptine

3

830

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.13 [0.71, 1.80]

5.15 Fluoxetine vs Trazodone

3

110

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.65 [0.21, 2.03]

5.16 Fluoxetine vs Venlafaxine

10

2036

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.76 [0.57, 1.03]

1 Failure to respond ‐ HDRS (‐50%) Show forest plot

17

1760

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.98 [0.81, 1.18]

1.1 Fluoxetine vs Amitriptyline

7

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.07 [0.75, 1.52]

1.2 Fluoxetine vs Clomipramine

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.3 Fluoxetine vs Desipramine

1

58

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.11 [0.38, 3.25]

1.4 Fluoxetine vs Dothiepine

2

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.09 [1.08, 4.05]

1.5 Fluoxetine vs Doxepine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.0 [0.29, 3.49]

1.6 Fluoxetine vs Imipramine

5

781

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.79 [0.59, 1.05]

1.7 Fluoxetine vs Lofepramine

1

183

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.99 [0.55, 1.77]

2 End‐point score on HDRS Show forest plot

35

2748

Std. Mean Difference (IV, Random, 95% CI)

0.06 [‐0.08, 0.21]

2.1 Fluoxetine vs Amiptriptyline

12

717

Std. Mean Difference (IV, Random, 95% CI)

0.08 [‐0.06, 0.23]

2.2 Fluoxetine vs Clomipramine

3

248

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.40, 0.10]

2.3 Fluoxetine vs Desipramine

3

121

Std. Mean Difference (IV, Random, 95% CI)

1.25 [‐1.28, 3.78]

2.4 Fluoxetine vs Dothiepine

4

266

Std. Mean Difference (IV, Random, 95% CI)

0.16 [‐0.27, 0.59]

2.5 Fluoxetine vs Imipramine

10

1040

Std. Mean Difference (IV, Random, 95% CI)

‐0.03 [‐0.23, 0.16]

2.6 Fluoxetine vs Lofepramine

1

183

Std. Mean Difference (IV, Random, 95% CI)

0.13 [‐0.16, 0.42]

2.7 Fluoxetine vs Nomifensine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.8 Fluoxetine vs Nortriptyline

1

154

Std. Mean Difference (IV, Random, 95% CI)

‐0.12 [‐0.44, 0.20]

2.9 Fluoxetine vs Trimipramine

1

19

Std. Mean Difference (IV, Random, 95% CI)

0.47 [‐0.44, 1.39]

3 Failure to complete ‐ Total Show forest plot

36

3494

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.78 [0.67, 0.91]

3.1 Fluoxetine vs Amitriptyline

11

764

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.63 [0.45, 0.89]

3.2 Fluoxetine vs Clomipramine

2

263

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.66 [0.38, 1.14]

3.3 Fluoxetine vs Desipramine

2

104

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.45 [0.17, 1.19]

3.4 Fluoxetine vs Dothiepine

5

478

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.44 [0.98, 2.12]

3.5 Fluoxetine vs Doxepine

3

272

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.76 [0.45, 1.28]

3.6 Fluoxetine vs Imipramine

10

1187

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.81 [0.64, 1.02]

3.7 Fluoxetine vs Lofepramine

1

183

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.51 [0.25, 1.03]

3.8 Fluoxetine vs Nomifensine

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.9 Fluoxetine vs Nortriptyline

2

243

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.58 [0.32, 1.08]

4 Failure to complete ‐ Inefficacy Show forest plot

27

2526

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.37 [1.03, 1.83]

4.1 Fluoxetine vs Amitriptyline

10

714

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.15 [0.54, 2.46]

4.2 Fluoxetine vs Clomipramine

1

120

Peto Odds Ratio (Peto, Fixed, 95% CI)

7.65 [0.78, 74.93]

4.3 Fluoxetine vs Desipramine

2

104

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.02 [0.19, 5.30]

4.4 Fluoxetine vs Dothiepine

3

271

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.35 [0.52, 3.49]

4.5 Fluoxetine vs Doxepine

2

232

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.70 [0.62, 4.67]

4.6 Fluoxetine vs Imipramine

9

1085

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.35 [0.94, 1.94]

4.7 Fluoxetine vs Nortriptyline

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Failure to complete ‐ Side Effects Show forest plot

32

3109

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.52 [0.43, 0.64]

5.1 Fluoxetine vs Amitriptyline

11

764

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.32 [0.20, 0.52]

5.2 Fluoxetine vs Clomipramine

2

263

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.34 [0.15, 0.78]

5.3 Fluoxetine vs Desipramine

2

104

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.25 [0.07, 0.92]

5.4 Fluoxetine vs Dothiepine

5

478

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.58 [0.90, 2.78]

5.5 Fluoxetine vs Doxepine

2

232

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.73 [0.42, 1.27]

5.6 Fluoxetine vs Imipramine

9

1085

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.48 [0.36, 0.64]

5.7 Fluoxetine vs Lofepramine

1

183

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.24 [0.05, 1.07]

5.8 Fluoxetine vs Nortriptyline

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

1 Failure to respond ‐ HDRS (‐50%) Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 Fluoxetine vs Maprotiline

2

163

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.92 [0.92, 3.98]

1.2 Fluoxetine vs Mianserin

1

53

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.81 [0.27, 2.36]

2 End‐point score on HDRS Show forest plot

6

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

2.6 Fluoxetine vs Maprotiline

3

252

Std. Mean Difference (IV, Random, 95% CI)

0.05 [‐0.20, 0.30]

2.7 Fluoxetine vs Mianserin

3

128

Std. Mean Difference (IV, Random, 95% CI)

0.43 [‐0.38, 1.23]

3 Failure to complete ‐ Total Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 Fluoxetine vs Maprotiline

2

163

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.05 [0.81, 5.21]

3.2 Fluoxetine vs Mianserin

2

93

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.67 [0.27, 1.70]

4 Failure to complete ‐ Inefficacy Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 Fluoxetine vs Maprotiline

2

163

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.01 [0.73, 12.41]

4.2 Fluoxetine vs Mianserin

1

53

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.18 [0.40, 11.74]

5 Failure to complete ‐ Side Effects Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 Fluoxetine vs Maprotiline

2

163

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.69 [0.12, 4.06]

5.2 Fluoxetine vs Mianserin

1

53

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.04 [0.24, 4.64]

1 Failure to respond ‐ HDRS (‐50%) Show forest plot

13

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 Fluoxetine vs Fluvoxamine

1

177

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.95 [0.52, 1.74]

1.2 Fluoxetine vs Paroxetine

8

960

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.25 [0.96, 1.63]

1.3 Fluoxetine vs Sertraline

6

1028

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.34 [1.04, 1.73]

2 End‐point score on HDRS Show forest plot

15

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

2.1 Fluoxetine vs Citalopram

2

610

Std. Mean Difference (IV, Random, 95% CI)

0.05 [‐0.10, 0.21]

2.2 Fluoxetine vs Paroxetine

8

920

Std. Mean Difference (IV, Random, 95% CI)

‐0.04 [‐0.45, 0.37]

2.3 Fluoxetine vs Sertraline

7

1070

Std. Mean Difference (IV, Random, 95% CI)

0.08 [‐0.04, 0.20]

3 Failure to complete ‐ Total Show forest plot

17

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 Fluoxetine vs Citalopram

2

673

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.87 [0.59, 1.27]

3.2 Fluoxetine vs Fluvoxamine

2

284

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.71 [0.37, 1.36]

3.3 Fluoxetine vs Paroxetine

7

854

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.98 [0.72, 1.34]

3.4 Fluoxetine vs Sertraline

8

1189

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.20 [0.92, 1.56]

4 Failure to complete ‐ Inefficacy Show forest plot

7

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 Fluoxetine vs Citalopram

2

673

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.90 [0.49, 1.65]

4.2 Fluoxetine vs Paroxetine

2

253

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.85 [0.25, 2.84]

4.3 Fluoxetine vs Sertraline

5

896

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.13 [0.62, 2.05]

5 Failure to complete ‐ Side Effects Show forest plot

16

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 Fluoxetine vs Citalopram

2

673

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.57 [0.30, 1.09]

5.2 Fluoxetine vs Fluvoxamine

1

100

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.04 [0.14, 7.63]

5.3 Fluoxetine vs Paroxetine

7

757

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.83 [0.52, 1.34]

5.4 Fluoxetine vs Sertraline

8

1189

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.19 [0.85, 1.66]

1 Failure to respond ‐ HDRS (‐50%) Show forest plot

32

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 Fluoxetine vs Amineptine

1

63

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.38 [0.14, 1.04]

1.2 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.19 [0.58, 2.43]

1.3 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.41 [0.61, 3.24]

1.4 Fluoxetine vs Hypericum

3

469

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.34 [0.93, 1.94]

1.5 Fluoxetine vs Milnacipram

1

300

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.15 [0.71, 1.86]

1.6 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.64 [1.01, 2.65]

1.7 Fluoxetine vs Moclobemide

6

651

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.30 [0.95, 1.78]

1.8 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.40 [0.28, 7.02]

1.9 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.55 [0.24, 1.26]

1.10 Fluoxetine vs Reboxetine

2

421

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.93 [0.63, 1.37]

1.11 Fluoxetine vs Tianeptine

1

387

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.12 [0.75, 1.66]

1.12 Fluoxetine vs Trazodone

3

110

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.55 [0.26, 1.16]

1.13 Fluoxetine vs Venlafaxine

9

1891

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.40 [1.15, 1.70]

2 End‐point score on HDRS Show forest plot

32

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

2.1 Fluoxetine vs ABT‐200

1

141

Std. Mean Difference (IV, Random, 95% CI)

‐1.85 [‐2.25, ‐1.45]

2.2 Fluoxetine vs Amisulpride

1

268

Std. Mean Difference (IV, Random, 95% CI)

0.17 [‐0.07, 0.41]

2.3 Fluoxetine vs Hypericum

3

448

Std. Mean Difference (IV, Random, 95% CI)

0.11 [‐0.08, 0.29]

2.4 Fluoxetine vs Milnacipram

1

149

Std. Mean Difference (IV, Random, 95% CI)

‐0.38 [‐0.71, ‐0.06]

2.5 Fluoxetine vs Moclobemide

5

487

Std. Mean Difference (IV, Random, 95% CI)

0.16 [‐0.02, 0.33]

2.6 Fluoxetine vs Nefazodone

3

238

Std. Mean Difference (IV, Random, 95% CI)

‐0.06 [‐0.32, 0.19]

2.7 Fluoxetine vs Phenelzine

1

40

Std. Mean Difference (IV, Random, 95% CI)

‐0.05 [‐0.67, 0.57]

2.8 Fluoxetine vs Reboxetine

1

168

Std. Mean Difference (IV, Random, 95% CI)

0.15 [‐0.16, 0.45]

2.9 Fluoxetine vs Tianeptine

3

730

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.40, 0.10]

2.10 Fluoxetine vs Trazodone

3

90

Std. Mean Difference (IV, Random, 95% CI)

‐0.06 [‐0.65, 0.53]

2.11 Fluoxetine vs Venlafaxine

10

1831

Std. Mean Difference (IV, Random, 95% CI)

0.11 [0.00, 0.23]

3 Failure to complete ‐ Total Show forest plot

41

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 Fluoxetine vs ABT‐200

1

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.21 [0.10, 0.41]

3.2 Fluoxetine vs Amineptine

2

232

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.71 [0.37, 1.38]

3.3 Fluoxetine vs Amisulpride

1

281

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.39 [0.81, 2.37]

3.4 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.15 [0.52, 2.52]

3.5 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.09 [0.46, 2.60]

3.6 Fluoxetine vs Hypericum

3

471

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.40 [0.68, 2.89]

3.7 Fluoxetine vs Milnacipram

2

490

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.93 [0.63, 1.38]

3.8 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.86 [0.52, 1.44]

3.9 Fluoxetine vs Moclobemide

6

651

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.02 [0.69, 1.50]

3.10 Fluoxetine vs Nefazodone

2

118

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.39 [0.14, 1.06]

3.11 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.13 [0.01, 2.13]

3.12 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.20 [0.08, 0.47]

3.13 Fluoxetine vs Reboxetine

2

421

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.61 [0.40, 0.94]

3.14 Fluoxetine vs Tianeptine

3

830

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.96 [0.69, 1.33]

3.15 Fluoxetine vs Trazodone

3

110

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.46 [0.21, 1.03]

3.16 Fluoxetine vs Venlafaxine

10

2036

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.94 [0.76, 1.15]

4 Failure to complete ‐ Inefficacy Show forest plot

37

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 Fluoxetine vs ABT‐200

1

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.29 [0.05, 1.72]

4.2 Fluoxetine vs Amineptine

1

63

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.04 [0.20, 5.49]

4.3 Fluoxetine vs Amisulpride

1

281

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.16 [0.44, 3.09]

4.4 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.74 [0.38, 19.95]

4.5 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.81 [0.56, 25.87]

4.6 Fluoxetine vs Hypericum

2

401

Peto Odds Ratio (Peto, Fixed, 95% CI)

6.88 [0.43, 111.26]

4.7 Fluoxetine vs Milnacipram

2

490

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.19 [0.69, 2.02]

4.8 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.28 [0.64, 8.10]

4.9 Fluoxetine vs Moclobemide

5

609

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.64 [0.30, 1.34]

4.10 Fluoxetine vs Nefazodone

2

118

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.13 [0.01, 2.15]

4.11 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.12 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.54 [0.08, 3.57]

4.13 Fluoxetine vs Reboxetine

2

421

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.96 [0.49, 1.87]

4.14 Fluoxetine vs Tianeptine

3

830

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.81 [0.41, 1.60]

4.15 Fluoxetine vs Trazodone

2

70

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.23 [0.04, 1.19]

4.16 Fluoxetine vs Venlafaxine

10

2036

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.32 [0.87, 1.99]

5 Failure to complete ‐ Side Effects Show forest plot

41

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 Fluoxetine vs ABT‐200

1

144

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.14 [0.06, 0.31]

5.2 Fluoxetine vs Amineptine

2

232

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.61 [0.22, 1.69]

5.3 Fluoxetine vs Amisulpride

1

281

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.77 [0.33, 1.81]

5.4 Fluoxetine vs Bupropion

1

123

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.64 [0.18, 2.31]

5.5 Fluoxetine vs Duloxetine

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.38 [0.08, 1.78]

5.6 Fluoxetine vs Hypericum

3

471

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.32 [0.52, 3.35]

5.7 Fluoxetine vs Milnacipram

2

490

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.46 [0.75, 2.84]

5.8 Fluoxetine vs Mirtazapine

2

265

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.82 [0.41, 1.65]

5.9 Fluoxetine vs Moclobemide

6

651

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.07 [0.64, 1.80]

5.10 Fluoxetine vs Nefazodone

3

243

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.73 [0.30, 1.76]

5.11 Fluoxetine vs Phenelzine

1

40

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.14 [0.00, 6.82]

5.12 Fluoxetine vs Pramipexole

1

105

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.19 [0.07, 0.51]

5.13 Fluoxetine vs Reboxetine

1

168

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.57 [0.20, 1.63]

5.14 Fluoxetine vs Tianeptine

3

830

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.13 [0.71, 1.80]

5.15 Fluoxetine vs Trazodone

3

110

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.65 [0.21, 2.03]

5.16 Fluoxetine vs Venlafaxine

10

2036

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.76 [0.57, 1.03]