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Comparison 1 D‐penicillamine versus placebo, Outcome 1 Mortality.
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Analysis 1.1

Comparison 1 D‐penicillamine versus placebo, Outcome 1 Mortality.

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Comparison 1 D‐penicillamine versus placebo, Outcome 2 Liver transplantation.
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Analysis 1.2

Comparison 1 D‐penicillamine versus placebo, Outcome 2 Liver transplantation.

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Comparison 1 D‐penicillamine versus placebo, Outcome 3 Hepatic histologic progression.
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Analysis 1.3

Comparison 1 D‐penicillamine versus placebo, Outcome 3 Hepatic histologic progression.

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Comparison 1 D‐penicillamine versus placebo, Outcome 4 Cholangiographic deterioration.
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Analysis 1.4

Comparison 1 D‐penicillamine versus placebo, Outcome 4 Cholangiographic deterioration.

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Comparison 1 D‐penicillamine versus placebo, Outcome 5 Bilirubin (mg/dl).
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Analysis 1.5

Comparison 1 D‐penicillamine versus placebo, Outcome 5 Bilirubin (mg/dl).

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Comparison 1 D‐penicillamine versus placebo, Outcome 6 Alkaline phosphatases (U/L).
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Analysis 1.6

Comparison 1 D‐penicillamine versus placebo, Outcome 6 Alkaline phosphatases (U/L).

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Comparison 1 D‐penicillamine versus placebo, Outcome 7 Aspartate aminotransferase (U/L).
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Analysis 1.7

Comparison 1 D‐penicillamine versus placebo, Outcome 7 Aspartate aminotransferase (U/L).

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Comparison 1 D‐penicillamine versus placebo, Outcome 8 Adverse events.
Figuras y tablas -
Analysis 1.8

Comparison 1 D‐penicillamine versus placebo, Outcome 8 Adverse events.

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Table 1. Search strategies

Database

Time span

Search strategy

Cochrane Hepato‐Biliary Group Controlled Trials Register

August 2005

cholangitis AND penicillamine

The Cochrane Central Register of Controlled Trials on The Cochrane Library

Issue 3, 2005

#1 CHOLANGITIS explode all trees (MeSH)
#2 cholangitis
#3 (#1 or #2)
#4 PENICILLAMINE explode all trees (MeSH)
#5 penicillamine
#6 (#4 or #5)
#7 (#3 and #6)

MEDLINE

1950 to August 2005

#1 explode "Cholangitis"/ all subheadings
#2 cholangitis
#3 #1 or #2
#4 explode "Penicillamine"/ all subheadings
#5 penicillamine
#6 #4 or #5
#7 #3 and #6
#8 random* or blind* or placebo or meta‐analysis
#9 #7 and #8

EMBASE

1980 to August 2005

#1 explode "cholangitis"/ all subheadings
#2 cholangitis
#3 #1 or #2
#4 explode "penicillamine"/ all subheadings
#5 penicillamine
#6 #4 or #5
#7 #3 and #6
#8 random* or blind* or placebo or meta‐analysis
#9 #7 and #8

Science Citation Index EXPANDED

1945 to August 2005

#1 TS=cholangitis
#2 TS=penicillamine
#3 #2 AND #1
#4 TS=(random* OR blind* OR placebo* OR meta‐analysis)
#5 #4 AND #3

Figuras y tablas -
Table 1. Search strategies
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Comparison 1. D‐penicillamine versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality Show forest plot

1

70

Risk Ratio (M‐H, Fixed, 95% CI)

1.14 [0.49, 2.64]

2 Liver transplantation Show forest plot

1

70

Risk Ratio (M‐H, Fixed, 95% CI)

1.11 [0.39, 3.17]

3 Hepatic histologic progression Show forest plot

1

70

Risk Ratio (M‐H, Fixed, 95% CI)

1.17 [0.79, 1.74]

4 Cholangiographic deterioration Show forest plot

1

70

Risk Ratio (M‐H, Fixed, 95% CI)

0.87 [0.43, 1.79]

5 Bilirubin (mg/dl) Show forest plot

1

60

Mean Difference (IV, Fixed, 95% CI)

0.40 [‐0.19, 0.99]

6 Alkaline phosphatases (U/L) Show forest plot

1

60

Mean Difference (IV, Fixed, 95% CI)

44.0 [‐37.89, 125.89]

7 Aspartate aminotransferase (U/L) Show forest plot

1

60

Mean Difference (IV, Fixed, 95% CI)

‐23.0 [‐30.66, ‐15.34]

8 Adverse events Show forest plot

1

70

Risk Ratio (M‐H, Fixed, 95% CI)

13.6 [0.82, 226.81]
Figuras y tablas -
Comparison 1. D‐penicillamine versus placebo
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