Vaginal chlorhexidine during labour for preventing maternal and neonatal infections (excluding Group B Streptococcal and HIV)

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Analysis 1.1

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 1 Chorioamnionitis.

Analysis 1.2

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 2 Postpartum endometritis.

Analysis 1.3

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 3 Side effects.

Analysis 1.4

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 4 Neonatal pneumonia.

Analysis 1.5

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 5 Neonatal meningitis.

Analysis 1.6

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 6 Blood culture confirming neonatal sepsis.

Analysis 1.7

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 7 Neonatal sepsis.

Analysis 1.8

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 8 Perinatal mortality.

Analysis 1.9

Comparison 1 Chlorhexidine vaginal wash versus placebo, Outcome 9 Newborn received antibiotics.

Comparison 1. Chlorhexidine vaginal wash versus placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Chorioamnionitis Show forest plot	3	3012	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.86, 1.42]

2 Postpartum endometritis Show forest plot	3	3012	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.61, 1.13]

3 Side effects Show forest plot	2	2065	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]

4 Neonatal pneumonia Show forest plot	1	910	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 8.09]

5 Neonatal meningitis Show forest plot	1	1024	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.01, 8.29]

6 Blood culture confirming neonatal sepsis Show forest plot	2	2077	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.17, 3.35]

7 Neonatal sepsis Show forest plot	3	2987	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.17, 3.35]

8 Perinatal mortality Show forest plot	2	2071	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.17, 5.79]

9 Newborn received antibiotics Show forest plot	1	910	Risk Ratio (M‐H, Fixed, 95% CI)	1.65 [0.73, 3.74]

Comparison 1. Chlorhexidine vaginal wash versus placebo