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Cochrane Database of Systematic Reviews

Strategien zur Spülung von langfristig liegenden Blasenkathetern bei Erwachsenen

Información

DOI:
https://doi.org/10.1002/14651858.CD004012.pub5Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 06 marzo 2017see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Incontinencia

Copyright:
  1. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Ashley J Shepherd

    Correspondencia a: Faculty of Health Sciences and Sport, University of Stirling, Stirling, UK

    [email protected]

  • William G Mackay

    Institute of Healthcare Policy and Practice, Health, Nursing and Midwifery, University of the West of Scotland, Paisley, UK

  • Suzanne Hagen

    Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UK

Contributions of authors

AS and SH independently assessed all titles and abstracts identified by the search strategy. AS, SH and WM completed the data extraction and quality assessment of all included trials. AS contacted authors of papers, and gathered additional data. SH was responsible for data entry, analysis and interpretation. WM provided clinical perspective and further interpretation. SH was the review guarantor.

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • National Institute for Health Research, UK.

    This project was supported by the National Institute for Health Research, via Cochrane Infrastructure, Cochrane Programme Grant or Cochrane Incentive funding to the Incontinence Group. The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the Systematic Reviews Programme, NIHR, NHS or the Department of Health.

Declarations of interest

Ashley Shepherd: None known.

Suzanne Hagen: None known.

William McKay: None known.

Acknowledgements

The review authors would like to thank Sheila Wallace of the Cochrane Incontinence Group for her assistance with searching and developing the search strategy. The authors would wish to thank both Lesley Sinclair and Stephen Cross who were co‐authors of the original review (Hagen 2010).

Version history

Published

Title

Stage

Authors

Version

2017 Mar 06

Washout policies in long‐term indwelling urinary catheterisation in adults

Review

Ashley J Shepherd, William G Mackay, Suzanne Hagen

https://doi.org/10.1002/14651858.CD004012.pub5

2010 Mar 17

Washout policies in long‐term indwelling urinary catheterisation in adults

Review

Suzanne Hagen, Lesley Sinclair, Stephen Cross

https://doi.org/10.1002/14651858.CD004012.pub4

2006 Jan 25

Washout policies for the management of long‐term indwelling urinary catheterisation in adults

Protocol

Lesley Sinclair, Stephen Cross, Suzanne Hagen, Barbara S Niël‐Weise

https://doi.org/10.1002/14651858.CD004012.pub3

2004 Jul 19

Washout policies for management of long‐term voiding problems in catheterised adults

Protocol

Lesley Sinclair, Stephen Cross, Suzanne Hagen, Barbara S Niël‐Weise

https://doi.org/10.1002/14651858.CD004012.pub2

2002 Oct 21

Washout policies for management of long‐term voiding problems in catheterised adults

Protocol

J Mooney, S Hagen, B Niel‐Weise

https://doi.org/10.1002/14651858.CD004012

Differences between protocol and review

For the 2017 update of the review there was no additional searching of databases other than the Cochrane Incontinence Specialised Register as this now includes relevant searches of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In‐Process, MEDLINE Epub Ahead of Print, CINAHL, ClinicalTrials.gov, WHO ICTRP, and UK Clinical Research Network Portfolio. Cochrane now organises centralised searches of Embase (including conference abstracts) that are included in CENTRAL so no additional Embase searches were performed. We continued to search the reference lists of relevant articles. The order of primary outcomes presented in the review has changed from the 2010 version following editors' advice.

Keywords

MeSH

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Study flow diagram
Figuras y tablas -
Figure 1

Study flow diagram

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies
Figuras y tablas -
Figure 2

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies

Methodological quality summary: review authors' judgements about each methodological quality item for each included study
Figuras y tablas -
Figure 3

Methodological quality summary: review authors' judgements about each methodological quality item for each included study

Comparison 1 Any washout versus no washout, Outcome 1 Number of participants with symptomatic UTI.
Figuras y tablas -
Analysis 1.1

Comparison 1 Any washout versus no washout, Outcome 1 Number of participants with symptomatic UTI.

Comparison 1 Any washout versus no washout, Outcome 2 weeks to first catheter change.
Figuras y tablas -
Analysis 1.2

Comparison 1 Any washout versus no washout, Outcome 2 weeks to first catheter change.

Comparison 1 Any washout versus no washout, Outcome 3 Number of participants needing catheter replacement.
Figuras y tablas -
Analysis 1.3

Comparison 1 Any washout versus no washout, Outcome 3 Number of participants needing catheter replacement.

Comparison 1 Any washout versus no washout, Outcome 4 Mean number of episodes of high temperature.
Figuras y tablas -
Analysis 1.4

Comparison 1 Any washout versus no washout, Outcome 4 Mean number of episodes of high temperature.

Comparison 1 Any washout versus no washout, Outcome 5 Mean number of episodes of high temperature of poss urinary origin.
Figuras y tablas -
Analysis 1.5

Comparison 1 Any washout versus no washout, Outcome 5 Mean number of episodes of high temperature of poss urinary origin.

Comparison 2 One washout solution versus another, Outcome 1 Number of participants with symptomatic UTI.
Figuras y tablas -
Analysis 2.1

Comparison 2 One washout solution versus another, Outcome 1 Number of participants with symptomatic UTI.

Comparison 2 One washout solution versus another, Outcome 2 weeks to first catheter change.
Figuras y tablas -
Analysis 2.2

Comparison 2 One washout solution versus another, Outcome 2 weeks to first catheter change.

Summary of findings for the main comparison. Any washout compared to no washout for participants with long‐term indwelling urinary catheterisation

Any washout compared to no washout for participants with long‐term indwelling urinary catheterisation

Patient or population: Long‐term indwelling urinary catheterisation in adults
Settings: Hospital and home
Intervention: Any washout
Comparison: No washout

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

No washout

Any washout

Symptomatic UTI

(Number of participants with symptomatic UTI, citric acid or saline washout versus no washout)

0 per 1000

0 per 1000

(0 to 0)

Not

estimable

53
(1 study)

⊕⊕⊝⊝
low1

No participants met the study criteria for symptomatic UTI

Symtomatic UTI

Mean number of episodes of high temperature (saline washout versus no washout)

The mean number of episodes of high temperature (saline washout versus no washout) in the intervention groups was:

0.78 (‐0.14 to 1.70)

Not estimable

23
(1 study)

⊕⊝⊝⊝
very low4,5

Symptomatic UTI

Mean number of episodes of high temperature due to possible urinary origin (saline washout versus no washout)

The mean number of episodes of high temperature of possible urinary origin (saline washout versus no washout) in the intervention groups was:

1.80 (1.02 to 2.58)

Not estimable

23
(1 study)

⊕⊝⊝⊝
very low4,6

Number of catheters used

(Number of participants needing catheter replacement, saline washout versus no washout)

526 per

1000

353 per 1000 (179 to 689)

RR 0.67
(0.34 to 1.31)

40
(1 study)

⊕⊝⊝⊝
very low2,3

Length of time each catheter was in situ

Not estimable

Not reported

No data available

Catheter removal rates due to blockage/infection

Not estimable

Not reported

No data available

Rates of asymptomatic bacteriuria

Not estimable

Not reported

No data available

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk ratio

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Downgraded two levels: The sample size was small (N = 53). Personnel not blinded to allocation of treatment. Blinding of outcome assessment not clear.
2 Downgraded two levels: The sample size was small (N = 40). The following were judged to be unclear: Random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessor, incomplete outcome data and selective reporting).
3 Downgraded one level for imprecision (95% CI was very wide: 0.34 to 1.31).
4 Downgraded two levels: The sample size was small (N = 23). The following domains were judged to be unclear: Random sequence generation, allocation concealment, and blinding of outcome assessor. Blinding of participants and personnel was judged to be at high risk of bias. Incomplete outcome data and selective reporting was judged to be at low risk of bias).
5 Downgraded one level for imprecision (95% CI ‐0.14 to 1.70). CI was very wide and crossed the line of no effect
6 Downgraded one level for imprecision (95% CI 1.02 to 2.58).

Figuras y tablas -
Summary of findings for the main comparison. Any washout compared to no washout for participants with long‐term indwelling urinary catheterisation
Summary of findings 2. One washout solution versus another for participants with long‐term indwelling urinary catheterisation

One washout solution versus another for participants with long‐term indwelling urinary catheterisation

Patient or population: Long‐term indwelling urinary catheterisation in adults
Settings: Hospital
Intervention: One washout solution versus another

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Control

One washout solution versus another

Symptomatic UTI

Number of participants with symptomatic UTI (citric acid versus saline)

0 per 1000

0 per 1000

(0 to 0)

Not estimable

33
(1 study)

⊕⊕⊝⊝
low1

No participants met the study criteria for symptomatic UTI

Symtomatic UTI

Mean number of episodes of high temperature

Not estimable

Not reported

No data available

Symptomatic UTI

Mean number of episodes of high temperature due to possible urinary origin

Not estimable

Not reported

No data available

Number of catheters used

Number of participants needing catheter replacement

Not estimable

Not reported

No data available

Length of time each catheter was in situ

Not estimable

Not reported

No data available

Catheter removal rates due to blockage/infection

Not estimable

Not reported

No data available

Rates of asymptomatic bacteriuria

Not estimable

Not reported

No data available

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk ratio;

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Downgraded two levels: The sample size was small (N = 33). Personnel not blinded to allocation of treatment. Blinding of outcome assessment not clear.

Figuras y tablas -
Summary of findings 2. One washout solution versus another for participants with long‐term indwelling urinary catheterisation
Comparison 1. Any washout versus no washout

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of participants with symptomatic UTI Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 any washout versus no washout

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 saline washout versus no washout

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.3 citric acid washout versus no washout

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 weeks to first catheter change Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 any washout versus no washout

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 saline washout versus no washout

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.3 citric acid washout versus no washout

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Number of participants needing catheter replacement Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

3.1 saline washout versus no washout

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.34, 1.31]

4 Mean number of episodes of high temperature Show forest plot

1

Mean Difference (Fixed, 95% CI)

Subtotals only

5 Mean number of episodes of high temperature of poss urinary origin Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 1. Any washout versus no washout
Comparison 2. One washout solution versus another

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of participants with symptomatic UTI Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 citric acid verus saline

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 weeks to first catheter change Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 citric acid verus saline

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figuras y tablas -
Comparison 2. One washout solution versus another