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Comparison 1 Oxygen therapy versus control, Outcome 1 Mortality.
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Analysis 1.1

Comparison 1 Oxygen therapy versus control, Outcome 1 Mortality.

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Comparison 1 Oxygen therapy versus control, Outcome 2 Change in lung function.
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Analysis 1.2

Comparison 1 Oxygen therapy versus control, Outcome 2 Change in lung function.

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Comparison 1 Oxygen therapy versus control, Outcome 3 Change in PaO2.
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Analysis 1.3

Comparison 1 Oxygen therapy versus control, Outcome 3 Change in PaO2.

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Comparison 1 Oxygen therapy versus control, Outcome 4 Change in PaCO2.
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Analysis 1.4

Comparison 1 Oxygen therapy versus control, Outcome 4 Change in PaCO2.

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Comparison 1 Oxygen therapy versus control, Outcome 5 Change in gas exchange during exercise.
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Analysis 1.5

Comparison 1 Oxygen therapy versus control, Outcome 5 Change in gas exchange during exercise.

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Comparison 1 Oxygen therapy versus control, Outcome 6 Change in gas exchange with sleep.
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Analysis 1.6

Comparison 1 Oxygen therapy versus control, Outcome 6 Change in gas exchange with sleep.

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Comparison 1 Oxygen therapy versus control, Outcome 7 Nutritional status: change in % ideal body weight for height.
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Analysis 1.7

Comparison 1 Oxygen therapy versus control, Outcome 7 Nutritional status: change in % ideal body weight for height.

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Comparison 1 Oxygen therapy versus control, Outcome 8 Quality of life: regular attendance at school or work.
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Analysis 1.8

Comparison 1 Oxygen therapy versus control, Outcome 8 Quality of life: regular attendance at school or work.

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Comparison 1 Oxygen therapy versus control, Outcome 9 Sleep parameters.
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Analysis 1.9

Comparison 1 Oxygen therapy versus control, Outcome 9 Sleep parameters.

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Comparison 1 Oxygen therapy versus control, Outcome 10 Exercise tolerance.
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Analysis 1.10

Comparison 1 Oxygen therapy versus control, Outcome 10 Exercise tolerance.

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Comparison 1 Oxygen therapy versus control, Outcome 11 Changes in right heart function.
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Analysis 1.11

Comparison 1 Oxygen therapy versus control, Outcome 11 Changes in right heart function.

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Table 1. Abbreviations

Abbreviations

Definition

BiPAP

bileval positive airway pressure

BMI

body mass index

CO2

carbon dioxide

COPD

chronic obstructive pulmonary disease

CPAP

continuous positive airway pressure

ETCO2

end tidal carbon dioxide tension

FEV1

forced expiratory volume in one second

FiO2

fraction of inspired oxygen, or percent of oxygen in the inspired gas

FVC

forced vital capacity

kPa

kilopascal, a unit of air pressure

LVEF

left ventricular ejection fraction

mm Hg

millimeter of mercury, a unit of air pressure

NIPPV

non‐invasive positive pressure ventilation

NREM

non‐rapid eye movement

PaCO2

arterial carbon dioxide tension

PaO2

partial pressure of oxygen in the blood

PCO2

partial pressure of carbon dioxide in the blood

PETCO2

maximum partial pressure of carbon dioxide exhaled during a tidal breath, just prior to inspiration

REM

rapid eye movement

RVEF

right ventricular ejection fraction

SaO2

saturation of haemoglobin with oxygen

SpO2

pulse oximetry

TcCO2

transcutaneous carbon dioxide

tPCO2

transcutaneous partial pressure of carbon dioxide in the blood

VCO2

carbon dioxide production

VE

mean total ventilation

VO2

oxygen consumption
Figuras y tablas -
Table 1. Abbreviations
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Comparison 1. Oxygen therapy versus control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 At 36 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Change in lung function Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 FEV1 at 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 FVC at 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Change in PaO2 Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 At 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Change in PaCO2 Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 At 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Change in gas exchange during exercise Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

5.1 Change in ETCO2 (mm Hg)

2

116

Mean Difference (IV, Fixed, 95% CI)

5.68 [4.79, 6.56]

5.2 Post exercise ETCO2 (mm Hg)

1

16

Mean Difference (IV, Fixed, 95% CI)

2.0 [‐1.46, 5.46]

6 Change in gas exchange with sleep Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 PtCO2 in REM sleep (KPa)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.2 Change in TcCO2 from NREM to REM sleep

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.3 Maximum TcCO2 with sleep (mm Hg)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Nutritional status: change in % ideal body weight for height Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 At 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Quality of life: regular attendance at school or work Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

8.1 At 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Sleep parameters Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

9.1 Total sleep time (minutes)

3

54

Mean Difference (IV, Fixed, 95% CI)

9.67 [‐16.35, 35.70]

9.2 Sleep latency (minutes)

2

38

Mean Difference (IV, Fixed, 95% CI)

‐4.48 [‐8.96, ‐0.00]

9.3 Arousal index

2

38

Mean Difference (IV, Fixed, 95% CI)

‐0.79 [‐2.58, 1.01]

9.4 Percent of total sleep time in REM sleep (%)

3

54

Mean Difference (IV, Fixed, 95% CI)

3.08 [‐0.08, 6.24]

10 Exercise tolerance Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

10.1 Exercise duration (minutes)

2

60

Mean Difference (IV, Fixed, 95% CI)

1.05 [0.82, 1.28]

11 Changes in right heart function Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

11.1 Clinical signs of cor pulmonale

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

11.2 Abnormal rIght ventricular ejection fraction at rest

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

11.3 Abnormal right ejection fraction with exercise

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Oxygen therapy versus control
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