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Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
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Figure 1

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

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Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
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Figure 2

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

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QUOROM Diagram
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Figure 3

QUOROM Diagram

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Funnel plot of comparison: 1 Loop diuretics vs placebo, outcome: 1.1 SBP.
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Figure 4

Funnel plot of comparison: 1 Loop diuretics vs placebo, outcome: 1.1 SBP.

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Funnel plot of comparison: 1 Loop diuretics vs placebo, outcome: 1.2 DBP.
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Figure 5

Funnel plot of comparison: 1 Loop diuretics vs placebo, outcome: 1.2 DBP.

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Funnel plot of comparison: 1 Loop diuretics vs placebo, outcome: 1.3 Withdrawals due to adverse effects.
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Figure 6

Funnel plot of comparison: 1 Loop diuretics vs placebo, outcome: 1.3 Withdrawals due to adverse effects.

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Forest plot of comparison: 2 loop diuretics vs placebo, outcome: 2.1 SBP.
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Figure 7

Forest plot of comparison: 2 loop diuretics vs placebo, outcome: 2.1 SBP.

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Forest plot of comparison: 2 loop diuretics vs placebo, outcome: 2.2 DBP.
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Figure 8

Forest plot of comparison: 2 loop diuretics vs placebo, outcome: 2.2 DBP.

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Forest plot of comparison: 2 loop diuretics vs placebo, outcome: 2.3 Withdrawals due to adverse events.
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Figure 9

Forest plot of comparison: 2 loop diuretics vs placebo, outcome: 2.3 Withdrawals due to adverse events.

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Comparison 1 Loop diuretics vs placebo, Outcome 1 SBP.
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Analysis 1.1

Comparison 1 Loop diuretics vs placebo, Outcome 1 SBP.

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Comparison 1 Loop diuretics vs placebo, Outcome 2 DBP.
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Analysis 1.2

Comparison 1 Loop diuretics vs placebo, Outcome 2 DBP.

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Comparison 1 Loop diuretics vs placebo, Outcome 3 Withdrawals due to adverse events.
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Analysis 1.3

Comparison 1 Loop diuretics vs placebo, Outcome 3 Withdrawals due to adverse events.

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Comparison 1 Loop diuretics vs placebo, Outcome 4 Serum potassium.
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Analysis 1.4

Comparison 1 Loop diuretics vs placebo, Outcome 4 Serum potassium.

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Comparison 1 Loop diuretics vs placebo, Outcome 5 Serum uric acid.
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Analysis 1.5

Comparison 1 Loop diuretics vs placebo, Outcome 5 Serum uric acid.

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Comparison 1 Loop diuretics vs placebo, Outcome 6 Serum creatinine.
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Analysis 1.6

Comparison 1 Loop diuretics vs placebo, Outcome 6 Serum creatinine.

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Comparison 1 Loop diuretics vs placebo, Outcome 7 Blood glucose.
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Analysis 1.7

Comparison 1 Loop diuretics vs placebo, Outcome 7 Blood glucose.

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Comparison 1 Loop diuretics vs placebo, Outcome 8 serum cholesterol.
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Analysis 1.8

Comparison 1 Loop diuretics vs placebo, Outcome 8 serum cholesterol.

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Comparison 1 Loop diuretics vs placebo, Outcome 9 Serum triglyceride.
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Analysis 1.9

Comparison 1 Loop diuretics vs placebo, Outcome 9 Serum triglyceride.

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Comparison 1. Loop diuretics vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 SBP Show forest plot

9

440

Mean Difference (IV, Fixed, 95% CI)

‐7.94 [‐10.45, ‐5.42]

1.1 Furosemide 40mg versus placebo

2

90

Mean Difference (IV, Fixed, 95% CI)

‐5.80 [‐12.96, 1.36]

1.2 Furosemide 60mg versus placebo

1

26

Mean Difference (IV, Fixed, 95% CI)

‐10.0 [‐15.77, ‐4.23]

1.3 Cicletanine 100mg versus placebo

1

39

Mean Difference (IV, Fixed, 95% CI)

‐7.0 [‐16.18, 2.18]

1.4 Cicletanine 150mg versus placebo

1

60

Mean Difference (IV, Fixed, 95% CI)

‐9.10 [‐15.54, ‐2.66]

1.5 Pretanide 3mg versus placebo

1

60

Mean Difference (IV, Fixed, 95% CI)

‐2.2 [‐9.97, 5.57]

1.6 Piretanide 6mg versus placebo

2

100

Mean Difference (IV, Fixed, 95% CI)

‐4.23 [‐10.00, 1.53]

1.7 Indacrinone enantiomer ‐2.5 /+ 80mg versus placebo

1

12

Mean Difference (IV, Fixed, 95% CI)

‐14.90 [‐31.15, 1.35]

1.8 Indacrinone ‐5.0 /+ 80mgversus placebo

1

12

Mean Difference (IV, Fixed, 95% CI)

‐11.70 [‐25.37, 1.97]

1.9 Indacrinone ‐10.0 /+ 80 mg versus placebo

1

13

Mean Difference (IV, Fixed, 95% CI)

‐19.1 [‐35.95, ‐2.25]

1.10 Etozolin 200mg versus placebo

1

28

Mean Difference (IV, Fixed, 95% CI)

‐14.30 [‐23.05, ‐5.55]

2 DBP Show forest plot

9

460

Mean Difference (IV, Fixed, 95% CI)

‐4.36 [‐5.87, ‐2.84]

2.1 Furosemide 40mg versus placebo

2

90

Mean Difference (IV, Fixed, 95% CI)

‐3.53 [‐7.28, 0.23]

2.2 Furosemide 60mg versus placebo

1

26

Mean Difference (IV, Fixed, 95% CI)

‐3.00 [‐7.26, 1.26]

2.3 Cicletanine 100mg versus placebo

1

39

Mean Difference (IV, Fixed, 95% CI)

‐3.30 [‐9.48, 2.88]

2.4 Cicletanine 150mg versus placebo

1

60

Mean Difference (IV, Fixed, 95% CI)

‐11.3 [‐15.30, ‐7.30]

2.5 Pretanide 3mg versus placebo

1

60

Mean Difference (IV, Fixed, 95% CI)

‐0.80 [‐5.44, 3.84]

2.6 Piretanide 6mg versus placebo

2

120

Mean Difference (IV, Fixed, 95% CI)

‐2.32 [‐5.48, 0.84]

2.7 Indacrinone enantiomer ‐2.5 /+ 80mg versus placebo

1

12

Mean Difference (IV, Fixed, 95% CI)

‐7.1 [‐15.16, 0.96]

2.8 Indacrinone ‐5.0 /+ 80mgversus placebo

1

12

Mean Difference (IV, Fixed, 95% CI)

‐3.40 [‐11.24, 4.44]

2.9 Indacrinone ‐10.0 /+ 80 mg versus placebo

1

13

Mean Difference (IV, Fixed, 95% CI)

‐3.40 [‐11.61, 4.81]

2.10 Etozolin 200mg versus placebo

1

28

Mean Difference (IV, Fixed, 95% CI)

‐7.30 [‐13.22, ‐1.38]

3 Withdrawals due to adverse events Show forest plot

6

331

Risk Ratio (M‐H, Fixed, 95% CI)

1.93 [0.34, 10.81]

4 Serum potassium Show forest plot

2

88

Mean Difference (IV, Fixed, 95% CI)

‐0.12 [‐0.36, 0.12]

4.1 Cicletanine 150mg

1

58

Mean Difference (IV, Fixed, 95% CI)

‐0.12 [‐0.36, 0.12]

4.2 Furosemide 40mg

1

30

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Serum uric acid Show forest plot

2

88

Mean Difference (IV, Fixed, 95% CI)

10.52 [‐17.88, 38.92]

5.1 Cicletanine 150mg

1

58

Mean Difference (IV, Fixed, 95% CI)

‐7.0 [‐40.75, 26.75]

5.2 Furosemide 40mg

1

30

Mean Difference (IV, Fixed, 95% CI)

53.00 [0.44, 105.56]

6 Serum creatinine Show forest plot

2

88

Mean Difference (IV, Fixed, 95% CI)

0.93 [‐5.74, 7.61]

6.1 Cicletanine 150mg

1

58

Mean Difference (IV, Fixed, 95% CI)

‐0.70 [‐9.63, 8.23]

6.2 Furosemide 40 mg

1

30

Mean Difference (IV, Fixed, 95% CI)

3.0 [‐7.05, 13.05]

7 Blood glucose Show forest plot

2

88

Mean Difference (IV, Fixed, 95% CI)

0.06 [‐0.19, 0.31]

7.1 Cicletanine 150mg

1

58

Mean Difference (IV, Fixed, 95% CI)

‐0.01 [‐0.40, 0.38]

7.2 Furosemide 40mg

1

30

Mean Difference (IV, Fixed, 95% CI)

0.1 [‐0.22, 0.42]

8 serum cholesterol Show forest plot

2

88

Mean Difference (IV, Fixed, 95% CI)

0.31 [‐0.17, 0.80]

8.1 Cicletanine 150mg

1

58

Mean Difference (IV, Fixed, 95% CI)

0.17 [‐0.51, 0.85]

8.2 Furosemide 40 mg

1

30

Mean Difference (IV, Fixed, 95% CI)

0.46 [‐0.23, 1.15]

9 Serum triglyceride Show forest plot

2

88

Mean Difference (IV, Fixed, 95% CI)

‐0.02 [‐0.35, 0.31]

9.1 Cicletanine 150mg

1

58

Mean Difference (IV, Fixed, 95% CI)

‐0.16 [‐0.54, 0.22]

9.2 Furosemide 40 mg

1

30

Mean Difference (IV, Fixed, 95% CI)

0.36 [‐0.27, 0.99]
Figuras y tablas -
Comparison 1. Loop diuretics vs placebo
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