Promoción del lavado de cara para prevenir el tracoma activo
Appendices
Appendix 1. CENTRAL search strategy
#1 MeSH descriptor: [Trachoma] explode all trees
#2 MeSH descriptor: [Chlamydia trachomatis] explode all trees
#3 trachom* or tracom*
#4 (follicular near/3 conjunctivitis)
#5 (intense near/3 conjunctivitis)
#6 Egyptian Ophthalmia*
#7 (Chlamydia* near/3 conjunctivitis)
#8 (granular near/3 conjunctivitis)
#9 (chlamydiasis or chlamidiosis)
#10 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #9
#11 MeSH descriptor: [Hygiene] explode all trees
#12 MeSH descriptor: [Face] explode all trees
#13 face* near/3 (wash* or clean* or hygien*)
#14 facial near/3 (wash* or clean* or hygien*)
#15 #11 or #12 or #13 or #14
#16 #10 and #15
Appendix 2. MEDLINE (OvidSP) search strategy
1. Randomized Controlled Trial.pt.
2. Controlled Clinical Trial.pt.
3. (randomized or randomised).ab,ti.
4. placebo.ab,ti.
5. drug therapy.fs.
6. randomly.ab,ti.
7. trial.ab,ti.
8. groups.ab,ti.
9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8
10. exp animals/ not humans.sh.
11. 9 not 10
12. exp Trachoma/
13. exp Chlamydia trachomatis/
14. trac?oma$.tw.
15. (follicular adj3 conjunctivitis).tw.
16. (intense adj3 conjunctivitis).tw.
17. Egyptian Ophthalmia$.tw.
18. ((Chlamydia$ adj3 conjunctivitis) or (granular adj3 conjunctivitis)).tw.
19. (chlamydiasis or chlamidiosis).tw.
20. 12 or 13 or 14 or 15 or 16 or 17 or 18
21. exp Hygiene/
22. exp Face/
23. (face$ adj3 (wash$ or clean$ or hygien$)).tw.
24. (facial adj3 (wash$ or clean$ or hygien$)).tw.
25. 21 or 22 or 23 or 24
26. 20 and 25
27. 11 and 26
The search filter for trials at the beginning of the strategy is adapted from the published paper by Glanville et al (Glanville 2006).
Appendix 3. EMBASE.com search strategy
#1 'randomized controlled trial'/exp
#2 'randomization'/exp
#3 'double blind procedure'/exp
#4 'single blind procedure'/exp
#5 random*:ab,ti
#6 #1 OR #2 OR #3 OR #4 OR #5
#7 'animal'/exp OR 'animal experiment'/exp
#8 'human'/exp
#9 #7 AND #8
#10 #7 NOT #9
#11 #6 NOT #10
#12 'clinical trial'/exp
#13 (clin* NEAR/3 trial*):ab,ti
#14 ((singl* OR doubl* OR trebl* OR tripl*) NEAR/3 (blind* OR mask*)):ab,ti
#15 'placebo'/exp
#16 placebo*:ab,ti
#17 random*:ab,ti
#18 'experimental design'/exp
#19 'crossover procedure'/exp
#20 'control group'/exp
#21 'latin square design'/exp
#22 #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21
#23 #22 NOT #10
#24 #23 NOT #11
#25 'comparative study'/exp
#26 'evaluation'/exp
#27 'prospective study'/exp
#28 control*:ab,ti OR prospectiv*:ab,ti OR volunteer*:ab,ti
#29 #25 OR #26 OR #27 OR #28
#30 #29 NOT #10
#31 #30 NOT (#11 OR #23)
#32 #11 OR #24 OR #31
#33 'trachoma'/exp
#34 'chlamydia trachomatis'/exp
#35 'chlamydiasis'/exp
#36 trachoma*:ab,ti OR tracoma*:ab,ti
#37 (egyptian NEAR/1 ophthalmia*):ab,ti
#38 (chlamydia* NEAR/3 conjunctivitis):ab,ti OR (granular NEAR/3 conjunctivitis):ab,ti
#39 chlamydiasis:ab,ti OR chlamidiosis:ab,ti
#40 (follicular NEAR/3 conjunctivitis):ab,ti
#41 (intense NEAR/3 conjunctivitis):ab,ti
#42 #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41
#43 'personal hygiene'/exp
#44 'face'/exp
#45 (face* NEAR/3 (wash* OR clean* OR hygien*)):ab,ti
#46 (facial NEAR/3 (wash* OR clean* OR hygien*)):ab,ti
#47 #43 OR #44 OR #45 OR #46
#48 #32 AND #42 AND #47
Appendix 4. PubMed search strategy
#1 ((randomized controlled trial[pt]) OR (controlled clinical trial[pt]) OR (randomised[tiab] OR randomized[tiab]) OR (placebo[tiab]) OR (drug therapy[sh]) OR (randomly[tiab]) OR (trial[tiab]) OR (groups[tiab])) NOT (animals[mh] NOT humans[mh])
#2 (trachoma*[tw] OR tracoma*[tw]) NOT Medline[sb]
#3 (follicular[tw] AND conjunctivitis[tw]) NOT Medline[sb]
#4 (intense[tw] AND conjunctivitis[tw]) NOT Medline[sb]
#5 Egyptian Ophthalmia*[tw] NOT Medline[sb]
#6 (chlamydia*[tw] AND conjunctivitis[tw]) NOT Medline[sb]
#7 (granular[tw] AND conjunctivitis[tw]) NOT Medline[sb]
#8 (chlamydiasis[tw] OR chlamidiosis[tw]) NOT Medline[sb]
#9 #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8
#10 (face*[tw] AND (wash*[tw] OR clean*[tw] OR hygien*[tw])) NOT Medline[sb]
#11 (facial AND (wash*[tw] OR clean*[tw] OR hygien*[tw])) NOT Medline[sb]
#12 #10 OR #11 OR #12
#13 #9 AND #12
#14 #1 AND #13
Appendix 5. LILACS search strategy
(Trachoma OR Tracoma OR "Egyptian Ophthalmia" OR MH:C01.252.354.225.800$ OR MH:C01.252.400.210.210.800$ OR MH:C01.539.375.354.220.800$ OR MH:C11.187.183.220.889$ OR MH:C11.204.813$ OR MH:C11.294.354.220.800$ OR MH:C23.996.850$ OR "Chlamydia trachomatis" OR MH:B03.440.190.190.190.750$ OR Chlamydia$ conjunctivitis OR "granular conjunctivitis" OR chlamydiasis OR chlamidiosis OR "follicular conjunctivitis" OR "intense conjunctivitis") AND (MH:E02.547$ OR MH:N06.850.670$ OR MH:SP4.001.017.193$ OR MH:A01.456.505$ OR ((Face$ OR Cara$ OR facial$) AND (wash$ OR clean$ OR Higien$ OR Hygien$)))
Appendix 6. metaRegister of Controlled Trials search strategy
(wash or clean or hygiene) and trachoma
Appendix 7. ClinicalTrials.gov search strategy
(wash OR clean OR hygiene) AND trachoma
Appendix 8. ICTRP search strategy
trachoma AND wash OR trachoma AND clean OR trachoma AND hygiene
Study flow diagram.
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Comparison 1 Eye wash versus control, Outcome 1 Presence of follicular trachoma.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Presence of follicular trachoma Show forest plot | 1 | 1143 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.03 [0.96, 1.11] |
| 1.1 with tetracycline eye drops in both groups | 1 | 686 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.03 [0.93, 1.14] |
| 1.2 without tetracycline eye drops in both groups | 1 | 457 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.02 [0.93, 1.13] |
