نقش کتامین به عنوان درمان کمکی اوپیوئیدها در مدیریت درد ناشی از سرطان
Appendices
Appendix 1. MEDLINE search strategy ‐ 2002
via OVID
-
KETAMINE (single term MeSH)
-
ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin or ketava or ketalin or ketina or brevinaze or keta‐hameln
-
OR/1‐2
-
Explode NEOPLASMS
-
BONE MARROW TRANSPLANTATION (single term MeSH)
-
neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan* or bone‐marrow‐transplant* or "bone marrow transplant*"
-
Explode RADIOTHERAPY
-
radiotherap* or radiation or irradiat* or radiochemo* or chemotherapy*
-
OR/4‐8
-
3 AND 9
The above subject search was linked to the Cochrane Sensitive Search strategy filter for RCTs:
-
randomized controlled trial.pt.
-
controlled clinical trial.pt.
-
randomized controlled trials.sh.
-
random allocation.sh.
-
double blind method.sh.
-
single blind method.sh.
-
or/1‐6
-
(ANIMALS not HUMAN).sh.
-
7 not 8
-
clinical trial.pt.
-
exp clinical trials/
-
(clin* adj25 trial*).ti,ab.
-
((singl* or doubl* or trebl* or tripl*) adj25 (blind* or mask*)).ti,ab.
-
placebos.sh.
-
placebo*.ti,ab.
-
random*.ti,ab.
-
research design.sh.
-
or/10‐17
-
18 not 8
-
19 not 9
-
9 or 19
Appendix 2. Other search strategies ‐ 2002
| Database | search strategy |
| PaPaS Trials register | ((ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin or ketava or ketalin or ketine or brevinaze or keta‐hameln) AND (neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan* or bone‐marrow‐transplant* or "bone marrow transplant*" or radiotherap* or radiation or irradiat* or radiochemo* or chemotherap*)) |
| CENTRAL | #1 KETAMINE (single term MeSH) |
| PubMed (for limit to Cancer subset) | #1 Search KETAMINE Field: MeSH Terms |
| Embase via OVID | 1 KETAMINE (single term MeSH) |
| THE PFIZER PRODUCT INFORMATION DATABASE (PPI) (2002‐2007) | 1 ((KETAMINE OR KETALAR) AND (CANCER* OR NEOPLASM* OR TUMOR* OR TUMOUR* OR CARCINOMA* OR MALIGNAN*)).AF 415 |
Appendix 3. CENTRAL search strategy ‐ 2012
#1 MeSH descriptor Ketamine explode all trees
#2 (ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin or ketava or ketalin or ketina or brevinaze or keta‐hameln):ti,ab,kw
#3 (#1 OR #2)
#4 MeSH descriptor Neoplasms explode all trees
#5 (neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan*):ti,ab,kw
#6 (#4 OR #5)
#7 (#3 AND #6)
Appendix 4. Embase search strategy ‐ 2012
Embase <1996 to May 2012
1 exp KETAMINE/
2 (ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin or ketava or ketalin or ketina or brevinaze or keta‐hameln).tw.
3 or/1‐2
4 exp neoplasm/
5 (neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan*).tw.
6 or/4‐5
7 3 and 6
8 Clinical trial/
9 Randomized controlled trial/
10 Randomization/
11 Single blind procedure/
12 Double blind procedure/
13 Crossover procedure/
14 Placebo/
15 randomi?ed controlled trial*.tw.
16 RCT.tw.
17 random allocation.tw.
18 randomly allocated.tw.
19 allocated randomly.tw.
20 (allocated adj2 random).tw.
21 single blind*.tw.
22 double blind*.tw.
23 ((treble or triple) adj blind*).tw.
24 placebo*.tw.
25 Prospective study/
26 or/8‐25
27 Case study/
28 case report.tw.
29 abstract report/ or letter/
30 or/27‐29
31 26 not 30
32 7 and 31
33 (2002* or 2003* or 2004* or 2005* or 2006* or 2007* or 2008* or 2009* or 2010* or 2011*).em.
34 32 and 33
Appendix 5. MEDLINE search strategy ‐ 2012
Database: Ovid MEDLINE(R) without Revisions <1996 to May 2012
1 exp Ketamine/
2 (ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin or ketava or ketalin or ketina or brevinaze or keta‐hameln).tw.
3 or/1‐2
4 exp Neoplasms/
5 (neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan*).tw.
6 or/4‐5
7 3 and 6
8 randomized controlled trial.pt.
9 controlled clinical trial.pt.
10 randomized.ab.
11 placebo.ab.
12 clinical trials as topic.sh.
13 randomly.ab.
14 trial.ti.
15 or/8‐14
16 exp animals/ not humans.sh.
17 15 not 16
18 7 and 17
19 (2002* or 2003* or 2004* or 2005* or 2006* or 2007* or 2008* or 2009* or 2010* or 2011*).ed.
20 18 and 19
Appendix 6. Searches 2017
CENTRAL (CRSO)
MESH DESCRIPTOR Ketamine
(ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin ketava or ketalin or ketina or brevinaze or keta‐hameln):TI,AB,KY
#1 OR #2
MESH DESCRIPTOR NEOPLASMS EXPLODE ALL TREES
MESH DESCRIPTOR BONE MARROW
MESH DESCRIPTOR Bone Marrow Transplantation
(neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan* or bone‐marrow‐transplant* or "bone marrow transplant*"):TI,AB,KY
MESH DESCRIPTOR RADIOTHERAPY EXPLODE ALL TREES
( radiotherap* or radiation or irradiat* or radiochemo* or chemotherap*):TI,AB,KY
#4 OR #5 OR #6 OR #7 OR #8 OR #9
#3 AND #10
MEDLINE (OVID)
1. Ketamine/
2. (ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin or ketava or ketalin or ketina or brevinaze or keta‐hameln).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]
3. 1 or 2
4. exp Neoplasms/
5. Bone Marrow Transplantation/
6. (neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan* or bone‐marrow‐transplant* or "bone marrow transplant*").mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]
7. exp Radiotherapy/
8. (radiotherap* or radiation or irradiat* or radiochemo* or chemotherapy*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]
9. or/4‐8
10. 3 and 9
11. randomized controlled trial.pt.
12. controlled clinical trial.pt.
13. randomized.ab.
14. placebo.ab.
15. drug therapy.fs.
16. randomly.ab.
17. trial.ab.
18. groups.ab.
19. 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18
20. exp animals/ not humans.sh.
21. 19 not 20
22. 10 and 21
Embase (OVID)
1. ketamine/
2. (ketamine or inducmina or ketalar or ketanest or calypso or narkamon or keta or velonarcon or ketmin or ketava or ketalin or ketina or brevinaze or keta‐hameln).tw.
3. 1 or 2
4. exp neoplasm/
5. (neoplas* or cancer* or carcinoma* or tumour* or tumor* or adenocarcinoma* or leukemi* or leukaemi* or lymphoma* or malignan*).tw.
6. or/4‐5
7. 5 or 6
8. 3 and 7
9. random$.tw.
10. factorial$.tw.
11. crossover$.tw.
12. cross over$.tw.
13. cross‐over$.tw.
14. placebo$.tw.
15. (doubl$ adj blind$).tw.
16. (singl$ adj blind$).tw.
17. assign$.tw.
18. allocat$.tw.
19. volunteer$.tw.
20. Crossover Procedure/
21. double‐blind procedure.tw.
22. Randomized Controlled Trial/
23. Single Blind Procedure/
24. or/9‐23
25. (animal/ or nonhuman/) not human/
26. 24 not 25
27. 8 and 26
Study flow diagram.
'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
