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Cochrane Database of Systematic Reviews

Entzündungshemmende Behandlung von Karditis bei akutem rheumatischem Fieber

Información

DOI:
https://doi.org/10.1002/14651858.CD003176.pub3Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 28 mayo 2015see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Corazón

Copyright:
  1. Copyright © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Contraer

Autores

  • Antoinette Cilliers

    Correspondencia a: Department of Paediatric Cardiology, Chris Hani Baragwanath Hospital, Johannesburg, South Africa

    [email protected]

  • Alma J Adler

    Department of Non‐communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK

  • Haroon Saloojee

    Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, South Africa

Contributions of authors

AMC. Conceived of, designed and co‐ordinated the review. Responsible for collecting and developing the research strategy, screening search results, organising retrieval of and screening papers, appraising the quality of papers, abstracting data, managing data for the review, entering data into RevMan, analysing and interpreting data, providing a methodological and clinical perspective, writing the review and performing previous work that was the foundation of the current study.

AJA. Prepared risk of bias tables, interpreted data and edited the paper.

HS. Interpreted data and provided methodological perspective and general advice on the review.

Sources of support

Internal sources

  • Chris Hani Baragwanath Hospital, Johannesburg, South Africa.

  • Guy's, King's & St Thomas' School of Medicine, King's College Hospital, UK.

External sources

  • Cochrane Heart Group Fellowship for Developing Countries, UK.

Declarations of interest

None.

Acknowledgements

The review authors would like to thank Juliet Manyemba for her contribution to previous versions of the reviews, for her appraisal of the quality of papers, assisting with abstraction of data from papers, analyses and interpretation of data and also providing a methodologic perspective and general advice. In addition, the authors would like to thank the editors and co‐ordinators of the Cochrane Heart Group for assistance provided.

Version history

Published

Title

Stage

Authors

Version

2015 May 28

Anti‐inflammatory treatment for carditis in acute rheumatic fever

Review

Antoinette Cilliers, Alma J Adler, Haroon Saloojee

https://doi.org/10.1002/14651858.CD003176.pub3

2012 Jun 13

Anti‐inflammatory treatment for carditis in acute rheumatic fever

Review

Antoinette Cilliers, Juliet Manyemba, Alma J Adler, Haroon Saloojee

https://doi.org/10.1002/14651858.CD003176.pub2

2003 Apr 22

Anti‐inflammatory treatment for carditis in acute rheumatic fever

Review

Antoinette Cilliers, Juliet Manyemba, Haroon Saloojee

https://doi.org/10.1002/14651858.CD003176

Keywords

MeSH

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 2

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Comparison 1 Corticosteroids versus aspirin, Outcome 1 Cardiac disease after 1 year.
Figuras y tablas -
Analysis 1.1

Comparison 1 Corticosteroids versus aspirin, Outcome 1 Cardiac disease after 1 year.

Comparison 1 Corticosteroids versus aspirin, Outcome 2 Outcome of severe cardiac disease after 1 year.
Figuras y tablas -
Analysis 1.2

Comparison 1 Corticosteroids versus aspirin, Outcome 2 Outcome of severe cardiac disease after 1 year.

Comparison 2 Individual corticosteroids versus aspirin, Outcome 1 Cardiac disease after 1 year.
Figuras y tablas -
Analysis 2.1

Comparison 2 Individual corticosteroids versus aspirin, Outcome 1 Cardiac disease after 1 year.

Comparison 1. Corticosteroids versus aspirin

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Cardiac disease after 1 year Show forest plot

6

907

Risk Ratio (M‐H, Random, 95% CI)

0.87 [0.66, 1.15]

2 Outcome of severe cardiac disease after 1 year Show forest plot

3

119

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.32, 2.70]

Figuras y tablas -
Comparison 1. Corticosteroids versus aspirin
Comparison 2. Individual corticosteroids versus aspirin

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Cardiac disease after 1 year Show forest plot

3

276

Risk Ratio (M‐H, Random, 95% CI)

0.86 [0.42, 1.76]

1.1 Hydrocortisone versus aspirin

1

64

Risk Ratio (M‐H, Random, 95% CI)

0.43 [0.19, 0.97]

1.2 Prednisone versus aspirin

2

212

Risk Ratio (M‐H, Random, 95% CI)

1.13 [0.52, 2.45]

Figuras y tablas -
Comparison 2. Individual corticosteroids versus aspirin