Drugs for discoid lupus erythematosus
Referencias
References to studies included in this review
References to studies excluded from this review
Additional references
Characteristics of studies
Characteristics of included studies [ordered by study ID]
Ir a:
| Methods | RCT, cross‐over at 6 weeks, duration 12 weeks. Data was analysed at 6 weeks as a parallel trial | |
| Participants | 78 adults, clinical diagnosis DLE well‐matched | |
| Interventions | Fluocinonide cream 0.05% vs hydrocortisone cream 1% given 3 times daily without occlusion | |
| Outcomes | Skin cleared or much improved ‐ the lowest score of 1 if the lesion was worse, the highest score 5 if the lesion was excellent or clear | |
| Notes | ‐ | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Adequate sequence generation? | Low risk | 'Patients were randomly assigned... ' No further details |
| Allocation concealment? | Unclear risk | No details about how the allocation sequence was concealed from the participants and clinicians |
| Blinding? | Low risk | It states this was a 'double‐blind' trial 'Both medications were supplied in a specially formulated cream base... in identical tubes'. Participants had one active lesion which was monitored every 3 weeks ‐ it is not clear if they were aware which lesion this was |
| Methods | RCT, duration 8 weeks (included DLE and subacute LE) | |
| Participants | 58 adults, clinical diagnosis DLE or SCLE, not matched for diagnosis | |
| Interventions | Acitretin 50mg vs hydroxychloroquine 400 to 1200mg daily | |
| Outcomes | An ordinal scale used to assess the skin initially and at follow‐up visits: Complete clearing = 0, improvement = 1, no change or deterioration = 2. Clearing of skin lesions and erythema were assessed | |
| Notes | ‐ | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Adequate sequence generation? | Low risk | '.. was conducted in a randomized fashion' and 'patients were randomly assigned' but no further details |
| Allocation concealment? | Unclear risk | No details about how the allocation sequence was concealed from the participants and clinicians |
| Blinding? | Low risk | It states a double‐blind study was performed but gives no further details |
Characteristics of excluded studies [ordered by study ID]
Ir a:
| Study | Reason for exclusion |
| Trial results included other disorders, outcome in DLE could not be established | |
| Not randomised | |
| Not randomised | |
| The results for DLE subset could not be established |
Data and analyses
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of skin lesions Show forest plot | 1 | 78 | Risk Ratio (M‐H, Fixed, 95% CI) | 2.77 [0.95, 8.08] |
| Analysis 1.1  Comparison 1 fluocinonide( 37) vs hydrocortisone cream (41), Outcome 1 Resolution of skin lesions. | ||||
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of skin lesions Show forest plot | 1 | 58 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.54, 1.59] |
| Analysis 2.1  Comparison 2 acitretin (28) versus hydroxychloroquine (30), Outcome 1 Resolution of skin lesions. | ||||
| 2 Clearing of erythema Show forest plot | 1 | 49 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.61 [0.36, 1.06] |
| Analysis 2.2  Comparison 2 acitretin (28) versus hydroxychloroquine (30), Outcome 2 Clearing of erythema. | ||||
Comparison 1 fluocinonide( 37) vs hydrocortisone cream (41), Outcome 1 Resolution of skin lesions.
Comparison 2 acitretin (28) versus hydroxychloroquine (30), Outcome 1 Resolution of skin lesions.
Comparison 2 acitretin (28) versus hydroxychloroquine (30), Outcome 2 Clearing of erythema.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of skin lesions Show forest plot | 1 | 78 | Risk Ratio (M‐H, Fixed, 95% CI) | 2.77 [0.95, 8.08] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of skin lesions Show forest plot | 1 | 58 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.54, 1.59] |
| 2 Clearing of erythema Show forest plot | 1 | 49 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.61 [0.36, 1.06] |
