Intra‐uterine insemination versus timed intercourse or expectant management for cervical hostility in subfertile couples

Frans M Helmerhorst; Huib AAM Van Vliet; Twina Gornas; M J Finken; David A Grimes

doi:10.1002/14651858.CD002809.pub2

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Analysis 1.1

Comparison 1 Intra uterine insemination without ovarian stimulation versus timed intercourse without ovarian stimulation, Outcome 1 Pregnancy.

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Analysis 1.2

Comparison 1 Intra uterine insemination without ovarian stimulation versus timed intercourse without ovarian stimulation, Outcome 2 Multiple pregnancies.

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Analysis 1.3

Comparison 1 Intra uterine insemination without ovarian stimulation versus timed intercourse without ovarian stimulation, Outcome 3 Spontaneous abortions.

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Analysis 1.4

Comparison 1 Intra uterine insemination without ovarian stimulation versus timed intercourse without ovarian stimulation, Outcome 4 Ovarian Hyperstimulation Syndrome.

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Analysis 2.1

Comparison 2 Intra uterine insemination with ovarian stimulation versus timed intercourse with ovarian stimulation, Outcome 1 Pregnancy.

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Analysis 2.2

Comparison 2 Intra uterine insemination with ovarian stimulation versus timed intercourse with ovarian stimulation, Outcome 2 Multiple pregnancies.

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Analysis 2.3

Comparison 2 Intra uterine insemination with ovarian stimulation versus timed intercourse with ovarian stimulation, Outcome 3 Spontaneous abortions.

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Analysis 2.4

Comparison 2 Intra uterine insemination with ovarian stimulation versus timed intercourse with ovarian stimulation, Outcome 4 Ovarian Hyperstimulation Syndrome.

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Table 1. Number of pregnancies per total number of cycles.

Study	Intrauterine Insemin	Timed Intercourse
Check 1995	17/80	3/76
Glazener 1987	2/223	3/252
Kirby 1991	7/58	4/52
Martinez 1990	1/3	0/4

Table 1. Number of pregnancies per total number of cycles.

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Comparison 1. Intra uterine insemination without ovarian stimulation versus timed intercourse without ovarian stimulation

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

1.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
1.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
1.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2 Multiple pregnancies Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

2.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3 Spontaneous abortions Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

3.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4 Ovarian Hyperstimulation Syndrome Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

4.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

Comparison 1. Intra uterine insemination without ovarian stimulation versus timed intercourse without ovarian stimulation

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Comparison 2. Intra uterine insemination with ovarian stimulation versus timed intercourse with ovarian stimulation

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

1.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
1.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
1.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2 Multiple pregnancies Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

2.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3 Spontaneous abortions Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

3.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4 Ovarian Hyperstimulation Syndrome Show forest plot	5	20	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

4.1 All trials	5	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.2 Only randomized controlled trials	3	6	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.3 Quasi randomized controlled trials	2	4	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

Comparison 2. Intra uterine insemination with ovarian stimulation versus timed intercourse with ovarian stimulation

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