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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 1 Mortality.
Figuras y tablas -
Analysis 1.1

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 1 Mortality.

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 2 Treatment with ECMO.
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Analysis 1.2

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 2 Treatment with ECMO.

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 3 Pneumothorax.
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Analysis 1.3

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 3 Pneumothorax.

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 4 Pulmonary interstitial emphysema.
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Analysis 1.4

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 4 Pulmonary interstitial emphysema.

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 5 Air leaks (pneumothorax, pneumomediastinum, interstitial emphysema).
Figuras y tablas -
Analysis 1.5

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 5 Air leaks (pneumothorax, pneumomediastinum, interstitial emphysema).

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 6 Duration of assisted mechanical ventilation (days).
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Analysis 1.6

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 6 Duration of assisted mechanical ventilation (days).

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 7 Duration of supplemental oxygen (days).
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Analysis 1.7

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 7 Duration of supplemental oxygen (days).

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 8 Need for supplemental oxygen at discharge.
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Analysis 1.8

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 8 Need for supplemental oxygen at discharge.

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 9 Chronic lung disease (age at diagnosis not stated).
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Analysis 1.9

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 9 Chronic lung disease (age at diagnosis not stated).

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 10 Intraventricular haemorrhage (any grade).
Figuras y tablas -
Analysis 1.10

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 10 Intraventricular haemorrhage (any grade).

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 11 Severe intraventricular haemorrhage.
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Analysis 1.11

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 11 Severe intraventricular haemorrhage.

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Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 12 Duration of hospital stay (days).
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Analysis 1.12

Comparison 1 Surfactant therapy vs. placebo or no therapy in term/near‐term infants, Outcome 12 Duration of hospital stay (days).

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Comparison 1. Surfactant therapy vs. placebo or no therapy in term/near‐term infants

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality Show forest plot

4

326

Risk Ratio (M‐H, Fixed, 95% CI)

0.98 [0.41, 2.39]

2 Treatment with ECMO Show forest plot

2

208

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.46, 0.91]

3 Pneumothorax Show forest plot

3

269

Risk Difference (M‐H, Fixed, 95% CI)

‐0.02 [‐0.08, 0.05]

4 Pulmonary interstitial emphysema Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5 Air leaks (pneumothorax, pneumomediastinum, interstitial emphysema) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

6 Duration of assisted mechanical ventilation (days) Show forest plot

3

158

Mean Difference (IV, Fixed, 95% CI)

0.60 [‐0.41, 1.62]

7 Duration of supplemental oxygen (days) Show forest plot

2

97

Mean Difference (IV, Fixed, 95% CI)

0.40 [‐2.83, 3.64]

8 Need for supplemental oxygen at discharge Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

9 Chronic lung disease (age at diagnosis not stated) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

10 Intraventricular haemorrhage (any grade) Show forest plot

2

229

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.31, 1.46]

11 Severe intraventricular haemorrhage Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

12 Duration of hospital stay (days) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only
Figuras y tablas -
Comparison 1. Surfactant therapy vs. placebo or no therapy in term/near‐term infants
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