Buprenorphine for the management of opioid withdrawal

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Ir a:

Analysis 1.1

Comparison 1 Buprenorphine versus clonidine, Outcome 1 Mean peak withdrawal score.

Analysis 1.2

Comparison 1 Buprenorphine versus clonidine, Outcome 2 Completion of withdrawal.

Analysis 1.3

Comparison 1 Buprenorphine versus clonidine, Outcome 3 Completion of treatment.

Analysis 1.4

Comparison 1 Buprenorphine versus clonidine, Outcome 4 Completion of treatment ‐ studies at low risk of selection bias.

Analysis 2.1

Comparison 2 Buprenorphine versus methadone, Outcome 1 Completion of withdrawal.

Comparison 1. Buprenorphine versus clonidine

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mean peak withdrawal score Show forest plot	3	266	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.61 [‐0.86, ‐0.36]

2 Completion of withdrawal Show forest plot	6	473	Risk Ratio (M‐H, Fixed, 95% CI)	1.42 [1.22, 1.66]

3 Completion of treatment Show forest plot	6	473	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [1.21, 1.57]

4 Completion of treatment ‐ studies at low risk of selection bias Show forest plot	5	349	Risk Ratio (M‐H, Fixed, 95% CI)	1.32 [1.14, 1.52]

Comparison 1. Buprenorphine versus clonidine

Comparison 2. Buprenorphine versus methadone

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Completion of withdrawal Show forest plot	2	63	Risk Ratio (M‐H, Fixed, 95% CI)	1.14 [0.87, 1.50]

Comparison 2. Buprenorphine versus methadone