Early administration of inhaled corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates

Vibhuti S Shah; Arne Ohlsson; Henry L Halliday; Michael Dunn

doi:10.1002/14651858.CD001969.pub2

Scolaris Content Display Scolaris Content Display

Contenido relacionado

Ir a:

Revisiones y protocolos relacionados
Guías
Temas

Revisiones y protocolos relacionados

Topics

Temas

Analysis 1.1

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 1 CLD at 36 weeks PMA.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.2

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 2 CLD at 28 days of age.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.3

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 3 Death by 28 days of age.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.4

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 4 Death by 36 weeks PMA.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.5

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 5 Death by or CLD at 28 days of age.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.6

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 6 Death by or CLD at 36 weeks PMA.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.7

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 7 Requirement for systemic steroids.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.8

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 8 Failure to extubate within 14 days.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.9

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 9 Infection.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.10

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 10 Hyperglycemia.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.11

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 11 Hypertension.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.12

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 12 Gastrointesinal bleeding.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.13

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 13 Cataract.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.14

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 14 Intraventricular hemorrhage.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.15

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 15 Periventricular leucomalacia.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.16

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 16 Necrotizing enterocolitis.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.17

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 17 Retinopathy of prematurity.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.18

Comparison 1 Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized), Outcome 18 Patent ductus arteriosus.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.1

Comparison 2 Early inhaled steroid (< 2 weeks) vs. placebo (among survivors), Outcome 1 CLD at 36 weeks PMA.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.2

Comparison 2 Early inhaled steroid (< 2 weeks) vs. placebo (among survivors), Outcome 2 CLD at 28 days of age.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.3

Comparison 2 Early inhaled steroid (< 2 weeks) vs. placebo (among survivors), Outcome 3 Cerebral palsy.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.4

Comparison 2 Early inhaled steroid (< 2 weeks) vs. placebo (among survivors), Outcome 4 Mean developmental index on BSID‐II < 2 SD of the mean.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.5

Comparison 2 Early inhaled steroid (< 2 weeks) vs. placebo (among survivors), Outcome 5 Respiratory readmission.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 1. Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 CLD at 36 weeks PMA Show forest plot	5	429	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.62, 1.52]

2 CLD at 28 days of age Show forest plot	5	429	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.84, 1.32]

3 Death by 28 days of age Show forest plot	5	429	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.39, 1.14]

4 Death by 36 weeks PMA Show forest plot	5	429	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.44, 1.21]

5 Death by or CLD at 28 days of age Show forest plot	5	429	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.80, 1.14]

6 Death by or CLD at 36 weeks PMA Show forest plot	5	429	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.63, 1.17]

7 Requirement for systemic steroids Show forest plot	6	461	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.69, 1.02]

8 Failure to extubate within 14 days Show forest plot	5	193	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.76, 1.24]

9 Infection Show forest plot	3	116	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.60, 2.09]

10 Hyperglycemia Show forest plot	3	116	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.49, 1.44]

11 Hypertension Show forest plot	3	116	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.36, 3.99]

12 Gastrointesinal bleeding Show forest plot	1	253	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.04, 3.34]

13 Cataract Show forest plot	1	253	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.01, 8.56]

14 Intraventricular hemorrhage Show forest plot	2	306	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.77, 1.41]

15 Periventricular leucomalacia Show forest plot	2	306	Risk Ratio (M‐H, Fixed, 95% CI)	1.43 [0.59, 3.46]

16 Necrotizing enterocolitis Show forest plot	2	306	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.41, 1.08]

17 Retinopathy of prematurity Show forest plot	2	306	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.87, 1.15]

18 Patent ductus arteriosus Show forest plot	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.57, 1.17]

Comparison 1. Early inhaled steroids (< 2 weeks) vs. placebo (among all randomized)

Ir a la tabla de la revisión

Comparison 2. Early inhaled steroid (< 2 weeks) vs. placebo (among survivors)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 CLD at 36 weeks PMA Show forest plot	5	362	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.57, 1.41]

2 CLD at 28 days of age Show forest plot	5	380	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.78, 1.21]

3 Cerebral palsy Show forest plot	1	56	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [0.33, 5.42]

4 Mean developmental index on BSID‐II < 2 SD of the mean Show forest plot	1	56	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.37, 4.17]

5 Respiratory readmission Show forest plot	1	56	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.44, 2.29]

Comparison 2. Early inhaled steroid (< 2 weeks) vs. placebo (among survivors)

Ir a la tabla de la revisión

The Cochrane Library

Scolaris Language Selector Scolaris Language Selector

Idioma de la Revisión Cochrane

Idioma de la web

Scolaris Content Language Banner Portlet Scolaris Content Language Banner Portlet