Antiplatelet therapy for preventing stroke in patients with non‐valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks

Maria I Aguilar; Robert Hart

doi:10.1002/14651858.CD001925.pub2

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Analysis 1.1

Comparison 1 Antiplatelet versus control, Outcome 1 All ischemic stroke or intracranial hemorrhage.

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Analysis 1.2

Comparison 1 Antiplatelet versus control, Outcome 2 All ischemic stroke (fatal and non‐fatal).

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Analysis 1.3

Comparison 1 Antiplatelet versus control, Outcome 3 All disabling or fatal ischemic stroke or intracranial hemorrhage.

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Analysis 1.4

Comparison 1 Antiplatelet versus control, Outcome 4 Myocardial infarction.

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Analysis 1.5

Comparison 1 Antiplatelet versus control, Outcome 5 All systemic emboli.

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Analysis 1.6

Comparison 1 Antiplatelet versus control, Outcome 6 All intracranial hemorrhage.

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Analysis 1.7

Comparison 1 Antiplatelet versus control, Outcome 7 All vascular death.

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Analysis 1.8

Comparison 1 Antiplatelet versus control, Outcome 8 All major extracranial bleeds.

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Analysis 1.9

Comparison 1 Antiplatelet versus control, Outcome 9 Composite: stroke (ischemic or hemorrhagic), myocardial infarction or vascular death.

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Analysis 1.10

Comparison 1 Antiplatelet versus control, Outcome 10 All‐cause mortality.

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Analysis 2.1

Comparison 2 Sensitivity analyses: three main aspirin trials plus SAFT (ASA + ineffective dose warfarin), Outcome 1 Three main aspirin trials plus SAFT. All ischemic stroke or intracranial hemorrhage.

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Analysis 2.2

Comparison 2 Sensitivity analyses: three main aspirin trials plus SAFT (ASA + ineffective dose warfarin), Outcome 2 Three main aspirin trials plus SAFT. Ischemic stroke (fatal and non‐fatal).

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Analysis 2.3

Comparison 2 Sensitivity analyses: three main aspirin trials plus SAFT (ASA + ineffective dose warfarin), Outcome 3 Three main aspirin trials plus SAFT. All‐cause mortality.

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Analysis 3.1

Comparison 3 Sensitivity analysis: non‐disabling stroke (all stroke minus disabling stroke), Outcome 1 All stroke minus disabling or fatal stroke (non‐disabling stroke).

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Comparison 1. Antiplatelet versus control

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All ischemic stroke or intracranial hemorrhage Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.70 [0.47, 1.07]

2 All ischemic stroke (fatal and non‐fatal) Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.70 [0.46, 1.07]

3 All disabling or fatal ischemic stroke or intracranial hemorrhage Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.86 [0.50, 1.49]

4 Myocardial infarction Show forest plot	2	1331	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.47 [0.19, 1.14]

5 All systemic emboli Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.67 [0.19, 2.33]

6 All intracranial hemorrhage Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.32 [0.22, 7.80]

7 All vascular death Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.82 [0.54, 1.25]

8 All major extracranial bleeds Show forest plot	2	1680	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.14 [0.44, 2.98]

9 Composite: stroke (ischemic or hemorrhagic), myocardial infarction or vascular death Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.71 [0.51, 0.97]

10 All‐cause mortality Show forest plot	3	2077	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.75 [0.54, 1.04]

Comparison 1. Antiplatelet versus control

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Comparison 2. Sensitivity analyses: three main aspirin trials plus SAFT (ASA + ineffective dose warfarin)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Three main aspirin trials plus SAFT. All ischemic stroke or intracranial hemorrhage Show forest plot	4	2633	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.73 [0.53, 1.00]

2 Three main aspirin trials plus SAFT. Ischemic stroke (fatal and non‐fatal) Show forest plot	4	2633	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.72 [0.52, 0.99]

3 Three main aspirin trials plus SAFT. All‐cause mortality Show forest plot	4	2745	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.78 [0.59, 1.02]

Comparison 2. Sensitivity analyses: three main aspirin trials plus SAFT (ASA + ineffective dose warfarin)

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Comparison 3. Sensitivity analysis: non‐disabling stroke (all stroke minus disabling stroke)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All stroke minus disabling or fatal stroke (non‐disabling stroke) Show forest plot	3	1965	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.56 [0.30, 1.03]

Comparison 3. Sensitivity analysis: non‐disabling stroke (all stroke minus disabling stroke)

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