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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 1 Lung function.
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Analysis 1.1

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 1 Lung function.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 2 Number of children from whom S. aureus isolated at least once.
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Analysis 1.2

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 2 Number of children from whom S. aureus isolated at least once.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 3 Z score weight (6 months to 3 years).
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Analysis 1.3

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 3 Z score weight (6 months to 3 years).

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 4 Z score length (6 months to 3 years).
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Analysis 1.4

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 4 Z score length (6 months to 3 years).

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 5 Number of children requiring admission (annualised rates).
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Analysis 1.5

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 5 Number of children requiring admission (annualised rates).

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 6 Days in hospital (annualised rates).
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Analysis 1.6

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 6 Days in hospital (annualised rates).

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 7 Number of children receiving additional antibiotics.
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Analysis 1.7

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 7 Number of children receiving additional antibiotics.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 8 Days of additional antibiotics.
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Analysis 1.8

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 8 Days of additional antibiotics.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 9 Number of children from whom H. influenzae isolated at least once.
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Analysis 1.9

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 9 Number of children from whom H. influenzae isolated at least once.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 10 Number of children from whom P. aeruginosa isolated at least once.
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Analysis 1.10

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 10 Number of children from whom P. aeruginosa isolated at least once.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 11 Adverse effects.
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Analysis 1.11

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 11 Adverse effects.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 12 Shwachman score.
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Analysis 1.12

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 12 Shwachman score.

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Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 13 Chrispin‐Norman Score.
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Analysis 1.13

Comparison 1 Continuous, oral, anti‐staphylococcal antibiotic prophylaxis, Outcome 13 Chrispin‐Norman Score.

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Table 1. Results of infant lung function testing (Beardsmore 1994)

Measurement

Prophylaxis (start)

As required (start)

Prophylaxis (1 year)

As required (1 year)

TGV (thoracic gas volume)

0.05

0.98

‐0.22

0.09

Gaw (airway conductance)

1.16

0.00

‐1.79

‐1.13

Vmax FRC (maximum flow at functional residual capacity)

‐0.69

‐0.75

‐0.61

‐0.85

(All lung function values expressed as standard error scores)
Figuras y tablas -
Table 1. Results of infant lung function testing (Beardsmore 1994)
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Comparison 1. Continuous, oral, anti‐staphylococcal antibiotic prophylaxis

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Lung function Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 FEV1 at 6 years

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 FVC at 6 years

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Number of children from whom S. aureus isolated at least once Show forest plot

3

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

2.1 1 year

2

248

Odds Ratio (M‐H, Fixed, 95% CI)

0.27 [0.15, 0.48]

2.2 2 years

3

315

Odds Ratio (M‐H, Fixed, 95% CI)

0.21 [0.13, 0.35]

2.3 3 years

2

260

Odds Ratio (M‐H, Fixed, 95% CI)

0.22 [0.13, 0.38]

2.4 4 years

1

127

Odds Ratio (M‐H, Fixed, 95% CI)

0.10 [0.04, 0.25]

2.5 5 years

1

98

Odds Ratio (M‐H, Fixed, 95% CI)

0.09 [0.03, 0.26]

2.6 6 years

1

43

Odds Ratio (M‐H, Fixed, 95% CI)

0.11 [0.03, 0.46]

3 Z score weight (6 months to 3 years) Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 6 months

1

32

Mean Difference (IV, Fixed, 95% CI)

0.30 [‐0.54, 1.14]

3.2 1 year

2

133

Mean Difference (IV, Fixed, 95% CI)

‐0.12 [‐0.50, 0.26]

3.3 2 years

2

140

Mean Difference (IV, Fixed, 95% CI)

0.06 [‐0.33, 0.45]

3.4 3 years

1

112

Mean Difference (IV, Fixed, 95% CI)

‐0.14 [‐0.58, 0.30]

4 Z score length (6 months to 3 years) Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 6 months

1

23

Mean Difference (IV, Fixed, 95% CI)

0.52 [‐0.36, 1.40]

4.2 1 year

2

127

Mean Difference (IV, Fixed, 95% CI)

0.06 [‐0.36, 0.48]

4.3 2 years

2

134

Mean Difference (IV, Fixed, 95% CI)

‐0.23 [‐0.65, 0.19]

4.4 3 years

1

112

Mean Difference (IV, Fixed, 95% CI)

‐0.07 [‐0.50, 0.36]

5 Number of children requiring admission (annualised rates) Show forest plot

3

243

Odds Ratio (M‐H, Fixed, 95% CI)

0.96 [0.50, 1.86]

6 Days in hospital (annualised rates) Show forest plot

3

242

Mean Difference (IV, Fixed, 95% CI)

0.88 [‐1.35, 3.10]

7 Number of children receiving additional antibiotics Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

8 Days of additional antibiotics Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

9 Number of children from whom H. influenzae isolated at least once Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9.1 2 years

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Number of children from whom P. aeruginosa isolated at least once Show forest plot

3

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

10.1 1 year

2

247

Odds Ratio (M‐H, Fixed, 95% CI)

1.42 [0.77, 2.60]

10.2 2 years

3

315

Odds Ratio (M‐H, Fixed, 95% CI)

0.74 [0.45, 1.23]

10.3 3 years

2

261

Odds Ratio (M‐H, Fixed, 95% CI)

0.88 [0.51, 1.51]

10.4 4 years

1

127

Odds Ratio (M‐H, Fixed, 95% CI)

1.28 [0.62, 2.64]

10.5 5 years

1

98

Odds Ratio (M‐H, Fixed, 95% CI)

1.97 [0.85, 4.58]

10.6 6 years

1

43

Odds Ratio (M‐H, Fixed, 95% CI)

3.67 [0.77, 17.35]

11 Adverse effects Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

11.1 Generalised rash

1

119

Mean Difference (IV, Fixed, 95% CI)

0.40 [‐0.07, 0.87]

11.2 Nappy rash

1

119

Mean Difference (IV, Fixed, 95% CI)

0.90 [‐1.06, 2.86]

11.3 Increased stool frequency

1

119

Mean Difference (IV, Fixed, 95% CI)

0.20 [‐2.18, 2.58]

12 Shwachman score Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

12.1 3 years

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

13 Chrispin‐Norman Score Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

13.1 3 years

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Continuous, oral, anti‐staphylococcal antibiotic prophylaxis
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