Over‐the‐counter (OTC) medications for acute cough in children and adults in ambulatory settings
Información
- DOI:
- https://doi.org/10.1002/14651858.CD001831.pub4Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 15 agosto 2012see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Infecciones respiratorias agudas
- Copyright:
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- Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Autores
Contributions of authors
Knut Schroeder (KS) and Tom Fahey (TF) conceived and designed the original review, undertook the searches, performed data collection, screened the search results, screened retrieved papers against the inclusion criteria, appraised the quality of the papers, extracted data from papers, interpreted the data, organised the retrieval of papers, wrote to authors of papers for additional information, managed the data, entered data into Review Manager (RevMan 2011) and wrote the review.
Susan Smith (SS) with TF and KS updated the review in 2007, 2010 and 2012, including screening updated search results, data extraction, quality appraisal and rewriting the review.
Sources of support
Internal sources
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Division of Primary Health Care, University of Bristol, UK.
External sources
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South & West Research and Development Directorate, UK.
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NHS Primary Care Career Scientist Fund, UK.
Declarations of interest
None known.
Acknowledgements
We thank the editorial team of the Cochrane Acute Respiratory Infections (ARI) Group for their excellent support and help with the literature searches. Steve McDonald and Ron D'Souza from the ARI Group helped design the initial search strategy and performed additional searches. Liz Dooley, Ruth Foxlee and Sarah Thorning provided further help and support with additional searches for the 2004, 2007, 2010 and 2012 updates.
We thank Professor Debbie Sharp (Division of Primary Health Care, University of Bristol) and Professor Massimo Pignatelli (Department of Histopathology, Bristol Royal Infirmary) for their help with the French and Italian translations.
Many thanks also to Bruce Arroll, Keith Dear, Warren McIsaac and Amy Zelmer for their very helpful comments on an earlier draft of this review. Thanks to Basem Saab, Martin Schultz, Mark Jones and Chris Del Mar for commenting on the 2007 revised draft. Finally, thanks also to Ntambwe Gustav Malangu, Nina Griese, Max Bulsara, Chris Del Mar and again to Martin Shultz for commenting on the 2010 revised draft.
Version history
| Published | Title | Stage | Authors | Version |
| 2014 Nov 24 | Over‐the‐counter (OTC) medications for acute cough in children and adults in community settings | Review | Susan M Smith, Knut Schroeder, Tom Fahey | |
| 2012 Aug 15 | Over‐the‐counter (OTC) medications for acute cough in children and adults in ambulatory settings | Review | Susan M Smith, Knut Schroeder, Tom Fahey | |
| 2008 Jan 23 | Over‐the‐counter (OTC) medications for acute cough in children and adults in ambulatory settings | Review | Susan M Smith, Knut Schroeder, Tom Fahey | |
| 2004 Oct 18 | Over‐the‐counter medications for acute cough in children and adults in ambulatory settings | Review | Knut Schroeder, Tom Fahey | |
| 2001 Jul 23 | Over‐the‐counter medications for acute cough in children and adults in ambulatory settings | Review | Knut Schroeder, Tom Fahey | |
Notes
A single randomised controlled trial (RCT) was added to this review in the 2008 update (Paul 2004). Paul et al tested a single nocturnal dose of dextromethorphan, or a single nocturnal dose of diphenhydramine versus placebo. The outcomes in this study were measured the following morning and included a cough severity index and a measure of sleep difficulty both for the affected children and their parents. This study showed no significant treatment differences between the two intervention groups and the control group. Average treatment differences were between 12% and 17% in favour of dextromethorphan for cough bouts (P = 0.004), cough components (P = 0.003) and cough effort (P = 0.001) with an increase in cough latency (P = 0.002).
A further single RCT was added for the 2010 update (Mizoguchi 2007). Mizoguchi et al compared a single nocturnal dose of a combination test syrup containing dextromethorphan, doxycycline, ephedrine and paracetamol with placebo. The outcomes in this study were measured the over the following two days and included proportions reporting improvements in cough three hours after taking the treatment and mean cough scores on day 1 and day 2. This study showed significant treatment differences between the two intervention groups and the control group in terms of reduction in mean cough scores on day 2.
The addition of these studies did not lead to any major changes in the conclusions of this review.
