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Comparison 1 Resin sealant versus no treatment, Outcome 1 Caries yes/no at 12 months.
Figuras y tablas -
Analysis 1.1

Comparison 1 Resin sealant versus no treatment, Outcome 1 Caries yes/no at 12 months.

Comparison 1 Resin sealant versus no treatment, Outcome 2 Caries yes/no at 24 months.
Figuras y tablas -
Analysis 1.2

Comparison 1 Resin sealant versus no treatment, Outcome 2 Caries yes/no at 24 months.

Comparison 1 Resin sealant versus no treatment, Outcome 3 Caries yes/no at 36 months.
Figuras y tablas -
Analysis 1.3

Comparison 1 Resin sealant versus no treatment, Outcome 3 Caries yes/no at 36 months.

Comparison 1 Resin sealant versus no treatment, Outcome 4 Caries yes/no at 48‐54 months.
Figuras y tablas -
Analysis 1.4

Comparison 1 Resin sealant versus no treatment, Outcome 4 Caries yes/no at 48‐54 months.

Comparison 1 Resin sealant versus no treatment, Outcome 5 12‐13 years ‐ 2‐year DFS increment.
Figuras y tablas -
Analysis 1.5

Comparison 1 Resin sealant versus no treatment, Outcome 5 12‐13 years ‐ 2‐year DFS increment.

Comparison 1 Resin sealant versus no treatment, Outcome 6 Caries yes/no at 9 years.
Figuras y tablas -
Analysis 1.6

Comparison 1 Resin sealant versus no treatment, Outcome 6 Caries yes/no at 9 years.

Comparison 2 Glass ionomer versus no treatment, Outcome 1 12‐13 years ‐ 2‐year DFS increment.
Figuras y tablas -
Analysis 2.1

Comparison 2 Glass ionomer versus no treatment, Outcome 1 12‐13 years ‐ 2‐year DFS increment.

Comparison 3 Glass ionomer versus resin sealant, Outcome 1 Caries yes/no at 24 months.
Figuras y tablas -
Analysis 3.1

Comparison 3 Glass ionomer versus resin sealant, Outcome 1 Caries yes/no at 24 months.

Comparison 3 Glass ionomer versus resin sealant, Outcome 2 Caries yes/no at 36‐44 months.
Figuras y tablas -
Analysis 3.2

Comparison 3 Glass ionomer versus resin sealant, Outcome 2 Caries yes/no at 36‐44 months.

Comparison 3 Glass ionomer versus resin sealant, Outcome 3 12‐13 years ‐ 2‐year DFS increment.
Figuras y tablas -
Analysis 3.3

Comparison 3 Glass ionomer versus resin sealant, Outcome 3 12‐13 years ‐ 2‐year DFS increment.

Comparison 3 Glass ionomer versus resin sealant, Outcome 4 Caries yes/no at 5 years.
Figuras y tablas -
Analysis 3.4

Comparison 3 Glass ionomer versus resin sealant, Outcome 4 Caries yes/no at 5 years.

Comparison 3 Glass ionomer versus resin sealant, Outcome 5 Caries yes/no at 7 years.
Figuras y tablas -
Analysis 3.5

Comparison 3 Glass ionomer versus resin sealant, Outcome 5 Caries yes/no at 7 years.

Comparison 4 Polyacid‐modified resin composite versus resin sealant, Outcome 1 Caries yes/no at 24 months.
Figuras y tablas -
Analysis 4.1

Comparison 4 Polyacid‐modified resin composite versus resin sealant, Outcome 1 Caries yes/no at 24 months.

Table 1. Data from split‐mouth studies

Comparison

Study

Both sound (+)

FS (+) control (‐)

FS (‐) control (+)

Both carious (‐)

RR (FE: 95% CI)

Het. Chi2

Resin FS versus no treatment:
12 months

Bojanini 1976

188

79

6

2

0.099 (0.049, 0.201)

Charbeneau 1979

104

82

5

11

0.172 (0.107, 0.276)

Sheykholeslam 1978

132

49

2

3

0.096 (0.040, 0.229)

POOLED

0.13 (0.09, 0.20)

2.34, 2 df, P = 0.31

Resin FS versus no treatment:
24 months

Brooks 1979

144

64

3

22

0.29 (0.206, 0.411)

Charbeneau 1979

53

100

4

29

0.256 (0.188, 0.348)

Sheykholeslam 1978

85

79

1

10

0.124 (0.071, 0.216)

POOLED

0.22 (0.15, 0.34)

6.63, 2 df, P = 0.04

Resin FS versus no treatment:
36 months

Brooks 1979

111

63

4

23

0.314 (0.225, 0.438)

Charbeneau 1979

45

96

5

47

0.364 (0.289, 0.457)

Hunter 1988

302

163

9

35

0.222 (0.169, 0.293)

POOLED

0.30 (0.22, 0.40)

7.35, 2 df, P = 0.03

Resin FS versus no treatment:
48‐54 months

Brooks 1979

61

67

3

37

0.385 (0.298, 0.496)

Charbeneau 1979

37

81

3

64

0.462 (0.385, 0.554)

Bravo 2005
(parallel group study )

0.24 (0.12, 0.45)

POOLED

0.40 (0.31, 0.51)

4.52, 2 df, P = 0.10

Glass ionomer versus
resin sealant: 12 months

No studies

Glass ionomer versus
resin sealant: 24 months

Poulsen 2001

191

2

9

1

3.33 (1.017, 10.922)
P = 0.065

Ganesh 2006

100

0

0

0

Not estimable

Mills 1993

59

0

0

0

Not estimable

Glass ionomer versus
resin sealant: 36‐44 months

Poulsen 2001
(resin better)

156

6

37

7

3.385 (1.978, 5.793)
P < 0.001

Arrow 1995
(ionomer better)

378

28

3

3

0.194 (0.087, 0.431)
P < 0.001

Kervanto‐Seppälä 2008
(resin better)

625

5

25

2

3.857 (1.767, 8.422)
P < 0.001

Glass ionomer versus
resin sealant: 7 years

Forss 1998
(no difference)

66

8

15

8

1.438 (0.881, 2.346)
P = 0.14

PMRC versus resin sealant: 24 months

Lampa 2004
(no difference)

41

3

0

0

OR = 0.23 (0.03, 1.76)
P = 0.16

Güngör 2004
(no difference)

50

10

8

2

OR = 0.80 (0.33, 1.97)
P = 0.63

POOLED

OR = 0.61 (0.23, 1.66)
P = 0.33

1.19, 1 df, P = 0.28

Figuras y tablas -
Table 1. Data from split‐mouth studies
Table 2. Data from parallel group study (Songpaisan 1995)

Comparison

Control number

Control mean

Control SD

Test number

Test mean

Test SD

Mean DFS diff.

95% CI

P value

Control versus resin

143

0.70

0.96

133

0.05

0.57

0.65

0.47 to 0.83

< 0.001

Control versus GI

143

0.70

0.96

261

0.52

1.09

0.18

‐0.034 to 0.39

0.09

Resin versus GI

133

0.05

0.57

261

0.52

1.09

‐0.47

‐0.63 to ‐0.31

< 0.001

Figuras y tablas -
Table 2. Data from parallel group study (Songpaisan 1995)
Table 3. Sealant retention

Time

Study

Sealant

Complete (%)

Partial (%)

Lost (%)

Decayed or filled (%)

Total (%)

Sealant retention:
12 months

Bojanini 1976

Delton (resin)

91

6

3

= 100

Charbeneau 1979

Kerr (resin)

79

17

4

= 100

Sheykholeslam 1978

Delton (resin)

92

5

0

3

= 100

Sealant retention:
24 months

Brooks 1979

Delton (resin)

84

10

6

= 100

Charbeneau 1979

Kerr (resin)

71

18

11

= 100

Sheykholeslam 1978

Delton (resin)

85

7

2

6

= 100

Songpaisan 1995

Fuji III (ionomer)

< 1

Songpaisan 1995

Delton (resin)

85

Poulsen 2001

Fuji III (ionomer)

9

9

82

= 100

Poulsen 2001

Delton (resin)

80

7

13

= 100

Ganesh 2006

Fuji VII (ionomer)

2

68

30

= 100

Ganesh 2006

Concise (resin)

4

66

30

= 100

Mills 1993

Ketac‐Silver (ionomer)

83

12

6

= 101

Mills 1993

Delton (resin)

58

17

25

= 100

Güngör 2004

Dyract Seal (PMRC)

80

16

4

= 100

Güngör 2004

Delton FS+ (resin)

71

16

13

= 100

Lampa 2004

Dyract Seal (PMRC)

16

44

40

= 100

Lampa 2004

Delton DDS (resin)

66

23

11

= 100

Sealant retention:
36 months

Brooks 1979

Delton (resin)

80

10

10

= 100

Charbeneau 1979

Kerr (resin)

61

23

16

= 100

Hunter 1988

Delton (resin)

64

19

8

9

= 100

Poulsen 2001

Fuji III (ionomer)

3

7

89

= 100

Poulsen 2001

Delton (resin)

74

16

10

= 100

Beiruti 2006

Fuji IX (ionomer)

60

Beiruti 2006

Visio‐Seal (composite resin)

60

Kervanto‐Seppälä 2008
retention stated by tooth pairs

In total 559 tooth pairs: in 1% ionomer retained, resin lost; in 89% ionomer lost, resin retained, in 6% ionomer retained, resin retained; in 4% ionomer lost, resin lost = 100%

Sealant retention:
44 months

Arrow 1995
retention stated by tooth pairs

In total 465 tooth pairs: in 10% ionomer retained, resin lost; in 18% ionomer lost, resin retained, in 10% ionomer retained, resin retained; in 62% ionomer lost, resin lost = 100%

Sealant retention:
48 months

Charbeneau 1979

Kerr (resin)

52

26

22

= 100

Sealant retention:
54 months

Brooks 1979

Delton (resin)

72

14

14

= 100

Sealant retention:
60 months

Beiruti 2006

Fuji IX (ionomer)

88

Beiruti 2006

Visio‐Seal (composite resin)

86

Sealant retention:
7 years

Forss 1998
retention stated by tooth pairs

In total 97 tooth pairs: in 6 % ionomer retained, resin lost; in 41% ionomer lost, resin retained, in 4% ionomer retained, resin retained; in 49% ionomer lost, resin lost = 100%

Sealant retention:
9 years

Bravo 2005

Delton (resin)

39

Figuras y tablas -
Table 3. Sealant retention
Comparison 1. Resin sealant versus no treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Caries yes/no at 12 months Show forest plot

3

Risk Ratio (Random, 95% CI)

0.13 [0.09, 0.20]

2 Caries yes/no at 24 months Show forest plot

3

Risk Ratio (Random, 95% CI)

0.22 [0.15, 0.34]

3 Caries yes/no at 36 months Show forest plot

3

Risk Ratio (Random, 95% CI)

0.30 [0.22, 0.40]

4 Caries yes/no at 48‐54 months Show forest plot

3

Risk Ratio (Random, 95% CI)

0.40 [0.31, 0.51]

5 12‐13 years ‐ 2‐year DFS increment Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6 Caries yes/no at 9 years Show forest plot

1

Risk Ratio (Fixed, 95% CI)

0.35 [0.22, 0.55]

Figuras y tablas -
Comparison 1. Resin sealant versus no treatment
Comparison 2. Glass ionomer versus no treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 12‐13 years ‐ 2‐year DFS increment Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 2. Glass ionomer versus no treatment
Comparison 3. Glass ionomer versus resin sealant

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Caries yes/no at 24 months Show forest plot

1

Risk Ratio (Fixed, 95% CI)

Totals not selected

2 Caries yes/no at 36‐44 months Show forest plot

4

Risk Ratio (Fixed, 95% CI)

Totals not selected

3 12‐13 years ‐ 2‐year DFS increment Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4 Caries yes/no at 5 years Show forest plot

1

Risk Ratio (Fixed, 95% CI)

0.28 [0.13, 0.61]

5 Caries yes/no at 7 years Show forest plot

1

Risk Ratio (Fixed, 95% CI)

1.44 [0.88, 2.35]

Figuras y tablas -
Comparison 3. Glass ionomer versus resin sealant
Comparison 4. Polyacid‐modified resin composite versus resin sealant

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Caries yes/no at 24 months Show forest plot

2

Odds ratio (Random, 95% CI)

0.61 [0.23, 1.66]

Figuras y tablas -
Comparison 4. Polyacid‐modified resin composite versus resin sealant