1 Global Rating (no change or improvement at 3 months) OC Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 galantamine (18mg/d bid or tid) vs placebo

1

135

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.96 [0.88, 4.37]

1.2 galantamine (24mg/d bid or tid) vs placebo

1

118

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.73 [0.73, 4.09]

1.3 galantamine (24‐32 mg/d bid or tid) vs placebo

1

281

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.28 [1.33, 3.91]

1.4 galantamine (36mg/d bid or tid) vs placebo

1

103

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.41 [1.22, 9.51]

2 Global Rating (no change or improvement at 6 months) OC Show forest plot

5

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

340

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.13 [0.71, 1.79]

2.2 galantamine (16mg/d bid) vs placebo

1

445

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.25 [1.55, 3.28]

2.3 galantamine (24mg/d bid) vs placebo

4

1314

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.05 [1.64, 2.56]

2.4 galantamine (32mg/d bid) vs placebo

2

606

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.94 [1.40, 2.69]

2.5 galantamine (32mg/d tds) vs placebo

1

414

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.30 [0.87, 1.94]

1 ADAS‐cog (Change from baseline at 3 months) OC Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (18mg/d bid) vs placebo

1

115

Mean Difference (IV, Fixed, 95% CI)

‐3.10 [‐5.45, ‐0.75]

1.2 galantamine (24mg/d bid) vs placebo

1

97

Mean Difference (IV, Fixed, 95% CI)

‐4.20 [‐6.84, ‐1.56]

1.3 galantamine (24‐32 mg/d bid or tid) vs placebo

1

278

Mean Difference (IV, Fixed, 95% CI)

‐1.90 [‐3.04, ‐0.76]

1.4 galantamine (32mg/d tds) vs placebo

1

398

Mean Difference (IV, Fixed, 95% CI)

‐2.4 [‐3.65, ‐1.15]

1.5 galantamine (36mg/d bid) vs placebo

1

82

Mean Difference (IV, Fixed, 95% CI)

‐4.1 [‐6.60, ‐1.60]

2 ADAS‐cog (Change from baseline at 6 months) OC Show forest plot

5

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

351

Mean Difference (IV, Fixed, 95% CI)

‐1.7 [‐3.02, ‐0.38]

2.2 galantamine (16mg/d bid) vs placebo

1

433

Mean Difference (IV, Fixed, 95% CI)

‐3.3 [‐4.45, ‐2.15]

2.3 galantamine (24mg/d bid) vs placebo

4

1290

Mean Difference (IV, Fixed, 95% CI)

‐3.38 [‐4.04, ‐2.72]

2.4 galantamine (32mg/d bid or tds) vs placebo

2

599

Mean Difference (IV, Fixed, 95% CI)

‐3.99 [‐4.99, ‐2.99]

2.5 galantamine (32mg/d tds) vs placebo

1

394

Mean Difference (IV, Fixed, 95% CI)

‐2.9 [‐4.29, ‐1.51]

1 ADAS‐cog (4 points or more improvement at 3 months) OC Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.3 galantamine (24‐32 mg/d bid or tid) vs placebo

1

270

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.79 [1.04, 3.09]

2 ADAS‐cog (4 points or more improvement at 6 months) OC Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

326

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.44 [0.81, 2.55]

2.2 galantamine (16mg/d bid) vs placebo

1

433

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.24 [1.47, 3.42]

2.3 galantamine (24mg/d bid) vs placebo

3

1051

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.42 [1.83, 3.20]

2.4 galantamine (32mg/d bid) vs placebo

2

597

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.72 [1.86, 3.96]

1 ADCS/ADL (Change from baseline at 6 months) OC Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (8mg/d bid) vs placebo

1

341

Mean Difference (IV, Fixed, 95% CI)

0.90 [‐1.22, 3.02]

1.2 galantamine (16mg/d bid) vs placebo

1

447

Mean Difference (IV, Fixed, 95% CI)

3.50 [1.84, 5.16]

1.3 galantamine (24mg/d bid) vs placebo

1

447

Mean Difference (IV, Fixed, 95% CI)

2.4 [0.74, 4.06]

1 NPI (Change from baseline at 3 months) OC Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (24‐32 mg/d bid or tid) vs placebo

1

282

Mean Difference (IV, Fixed, 95% CI)

‐0.7 [‐4.07, 2.67]

2 NPI (Change from baseline at 6 months) OC Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

340

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐2.55, 2.55]

2.2 galantamine (16mg/d bid) vs placebo

1

445

Mean Difference (IV, Fixed, 95% CI)

‐2.4 [‐4.48, ‐0.32]

2.3 galantamine (24mg/d bid) vs placebo

2

677

Mean Difference (IV, Fixed, 95% CI)

‐2.09 [‐3.84, ‐0.34]

1 DAD (Change from baseline at 3 months) OC Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (24‐32 mg/d bid or tid) vs placebo

1

282

Mean Difference (IV, Fixed, 95% CI)

4.3 [1.46, 7.14]

2 DAD (Change from baseline at 6 months) OC Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 galantamine (24mg/d bid) vs placebo

2

575

Mean Difference (IV, Fixed, 95% CI)

3.87 [1.34, 6.39]

2.2 galantamine (32mg/d bid) vs placebo

1

334

Mean Difference (IV, Fixed, 95% CI)

3.80 [0.29, 7.31]

1 Global Rating (no change or improvement at 3 months) ITT Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 galantamine (18mg/d bid) vs placebo

1

162

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.44 [1.18, 5.04]

1.2 galantamine (24mg/d bid) vs placebo

1

136

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.11 [0.96, 4.62]

1.3 galantamine (24‐32 mg/d bid or tid) vs placebo

1

363

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.48 [0.92, 2.37]

1.4 galantamine (36mg/d bid) vs placebo

1

130

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.70 [1.18, 6.17]

2 Global Rating (no change or improvement at 6 months) ITT Show forest plot

5

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

391

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.17 [0.77, 1.78]

2.2 galantamine (16mg/d bid) vs placebo

1

517

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.04 [1.44, 2.89]

2.3 galantamine (24mg/d bid) vs placebo

4

1570

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.90 [1.55, 2.33]

2.4 galantamine (32mg/d bid) vs placebo

2

768

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.79 [1.34, 2.38]

2.5 galantamine (32mg/d tds) vs placebo

1

525

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.28 [0.89, 1.83]

1 ADAS‐cog (Change from baseline at 3 months) ITT Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (18mg/d bid) vs placebo

1

163

Mean Difference (IV, Fixed, 95% CI)

‐1.70 [‐3.64, 0.24]

1.2 galantamine (24mg/d bid) vs placebo

1

137

Mean Difference (IV, Fixed, 95% CI)

‐3.0 [‐5.23, ‐0.77]

1.3 galantamine (24‐32 mg/d bid or tid) vs placebo

1

359

Mean Difference (IV, Fixed, 95% CI)

‐1.70 [‐2.79, ‐0.61]

1.4 galantamine (36mg/d bid) vs placebo

1

133

Mean Difference (IV, Fixed, 95% CI)

‐2.3 [‐4.24, ‐0.36]

2 ADAS‐cog (Change from baseline at 6 months) ITT Show forest plot

5

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

381

Mean Difference (IV, Fixed, 95% CI)

‐1.30 [‐2.57, ‐0.03]

2.2 galantamine (16mg/d bid) vs placebo

1

508

Mean Difference (IV, Fixed, 95% CI)

‐3.10 [‐4.13, ‐2.07]

2.3 galantamine (24mg/d bid) vs placebo

4

1630

Mean Difference (IV, Fixed, 95% CI)

‐3.13 [‐3.70, ‐2.55]

2.4 galantamine (32mg/d bid) vs placebo

2

825

Mean Difference (IV, Fixed, 95% CI)

‐3.29 [‐4.14, ‐2.44]

2.5 galantamine (32mg/d tds) vs placebo

1

553

Mean Difference (IV, Fixed, 95% CI)

‐2.9 [‐4.01, ‐1.79]

1 ADAS‐cog (4 points or more improvement at 3 months) OC Show forest plot

1

359

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.46 [0.90, 2.39]

1 ADCS/ADL (Change from baseline at 6 months) ITT Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (8mg/d bid) vs placebo

1

391

Mean Difference (IV, Fixed, 95% CI)

0.60 [‐1.36, 2.56]

1.2 galantamine (16mg/d bid) vs placebo

1

517

Mean Difference (IV, Fixed, 95% CI)

3.10 [1.57, 4.63]

1.3 galantamine (24mg/d bid) vs placebo

1

515

Mean Difference (IV, Fixed, 95% CI)

2.3 [0.64, 3.96]

1 NPI (Change from baseline at 3 months) ITT Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (24‐32 mg/d bid or tid) vs placebo

1

364

Mean Difference (IV, Fixed, 95% CI)

‐0.8 [‐2.67, 1.07]

2 NPI (Change from baseline at 6 months) ITT Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

391

Mean Difference (IV, Fixed, 95% CI)

0.30 [‐2.09, 2.69]

2.2 galantamine (16mg/d bid) vs placebo

1

517

Mean Difference (IV, Fixed, 95% CI)

‐2.1 [‐4.04, ‐0.16]

2.3 galantamine (24mg/d bid) vs placebo

2

788

Mean Difference (IV, Fixed, 95% CI)

‐1.49 [‐3.11, 0.13]

1 DAD (Change from baseline at 3 months) ITT Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 galantamine (24‐32 mg/d bid or tid) vs placebo

1

364

Mean Difference (IV, Fixed, 95% CI)

4.8 [2.05, 7.55]

2 DAD (Change from baseline at 6 months) ITT Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 galantamine (24mg/d bid) vs placebo

2

701

Mean Difference (IV, Fixed, 95% CI)

3.66 [1.41, 5.90]

2.2 galantamine (32mg/d bid) vs placebo

1

424

Mean Difference (IV, Fixed, 95% CI)

3.5 [0.52, 6.48]

1 Global Rating (no change or improvement; 8 mg) OC Show forest plot

1

340

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.13 [0.71, 1.79]

2 Global Rating (no change or improvement 16‐18mg/d) OC Show forest plot

2

580

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.20 [1.56, 3.09]

3 Global Rating (no change or improvement 24mg/d to 24‐32mg/d) OC Show forest plot

6

1713

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.06 [1.69, 2.52]

4 Global Rating (no change or improvement 32‐36mg/d) OC Show forest plot

4

1123

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.72 [1.35, 2.20]

1 Global Rating (no change or improvement; 8 mg) ITT Show forest plot

1

391

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.17 [0.77, 1.78]

2 Global Rating (no change or improvement 16‐18mg/d) ITT Show forest plot

2

679

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.11 [1.54, 2.88]

3 Global Rating (no change or improvement 24mg/d to 24‐32mg/d) ITT Show forest plot

6

2069

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.84 [1.53, 2.21]

4 Global Rating (no change or improvement 32‐36mg/d) ITT Show forest plot

4

1423

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.63 [1.31, 2.02]

1 Proportion of all cause discontinuations (3 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.03 [1.00, 4.13]

1.2 galantamine (24mg/d bid) vs placebo

1

143

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.75 [0.75, 4.08]

1.3 galantamine (24mg/d to 24‐32mg/d) vs placebo

1

386

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.42 [2.10, 5.58]

1.4 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.79 [2.26, 10.14]

2 Proportion of discontinuations due to adverse events (3 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.57 [1.13, 5.83]

2.2 galantamine (24mg/d bid) vs placebo

1

143

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.99 [1.03, 8.64]

2.3 galantamine (24mg/d to 24‐32mg/d) vs placebo

1

386

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.11 [2.37, 7.13]

2.4 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

9.26 [4.05, 21.17]

3 Proportion of all cause discontinuations (6 months) Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 galantamine (8mg/d bid) vs placebo

1

426

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.57 [0.93, 2.65]

3.2 galantamine (16mg/d bid) vs placebo

1

565

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.43 [0.94, 2.18]

3.3 galantamine (24mg/d bid) vs placebo

3

1419

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.67 [1.29, 2.17]

3.4 galantamine (32mg/d bid) vs placebo

2

857

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.55 [1.87, 3.48]

3.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.36 [1.62, 3.45]

4 Proportion of discontinuations due to adverse events (6 months) Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 galantamine (8mg/d bid) vs placebo

1

426

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.92 [0.41, 2.04]

4.2 galantamine (16mg/d bid) vs placebo

1

565

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.97 [0.51, 1.86]

4.3 galantamine (24mg/d bid) vs placebo

3

1419

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.09 [1.51, 2.91]

4.4 galantamine (32mg/d bid) vs placebo

2

857

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.64 [2.56, 5.18]

4.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.79 [1.81, 4.28]

1 Proportion of subjects experiencing nausea (3 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.33 [1.64, 11.45]

1.2 galantamine (24‐32mg/d bid) vs placebo

2

529

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.32 [2.11, 5.21]

1.4 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

11.51 [4.61, 28.75]

2 Proportion of subjects experiencing vomiting (3 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.59 [1.39, 9.29]

2.2 galantamine (24‐32mg/d bid) vs placebo

2

529

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.14 [1.75, 5.63]

2.3 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.19 [1.30, 13.48]

3 Proportion of subjects experiencing dizziness (3 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.33 [0.29, 6.00]

3.2 galantamine (24‐32mg/d bid) vs placebo

2

529

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.60 [1.39, 4.88]

3.3 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.30 [0.48, 10.92]

4 Proportion of subjects experiencing diarrhea (3 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.99 [0.14, 7.14]

4.2 galantamine (24‐32mg/d bid) vs placebo

1

143

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.46 [0.40, 15.20]

4.3 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.66 [0.22, 12.73]

5 Proportion of subjects experiencing anorexia (3 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 galantamine (24‐32mg/d bid) vs placebo

1

386

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.24 [1.53, 6.88]

6 Proportion of subjects experiencing somnolence (3 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

6.1 galantamine (24‐32mg/d bid) vs placebo

1

386

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.78 [1.48, 9.67]

7 Proportion of subjects experiencing abdominal pain (3 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

7.1 galantamine (24‐32mg/d bid) vs placebo

1

386

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.93 [1.12, 7.66]

8 Proportion of subjects experiencing decreased appetite (3 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

8.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.40 [0.53, 10.85]

8.2 galantamine (24‐32mg/d bid) vs placebo

1

143

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.59 [0.21, 12.11]

8.3 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.47 [0.65, 18.56]

9 Proportion of subjects experiencing agitation (3 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

9.1 galantamine (24‐32mg/d bid) vs placebo

1

386

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.54 [1.25, 9.98]

10 Proportion of subjects experiencing headache (3 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

10.1 galantamine (18mg/d bid) vs placebo

1

175

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.25 [0.33, 4.75]

10.2 galantamine (24‐32mg/d bid) vs placebo

1

143

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.54 [0.69, 9.45]

10.3 galantamine (36mg/d bid) vs placebo

1

141

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.80 [1.36, 16.96]

1 Proportion of subjects experiencing nausea (6 months) Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

1.1 galantamine (8mg/d bid) vs placebo

1

426

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.28 [0.50, 3.26]

1.2 galantamine (16mg/d bid) vs placebo

1

565

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.94 [1.65, 5.25]

1.3 galantamine (24mg/d bid) vs placebo

3

1419

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.69 [2.82, 4.82]

1.4 galantamine (32mg/d bid) vs placebo

2

856

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.21 [1.66, 2.94]

1.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.58 [3.00, 6.98]

2 Proportion of subjects experiencing vomiting (6 months) Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2.1 galantamine (8mg/d bid) vs placebo

1

426

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.85 [0.70, 11.62]

2.2 galantamine (16mg/d bid) vs placebo

1

565

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.70 [1.55, 8.85]

2.3 galantamine (24mg/d bid) vs placebo

3

1419

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.01 [2.15, 4.21]

2.4 galantamine (32mg/d bid) vs placebo

2

857

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.07 [2.09, 4.50]

2.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

6.33 [3.33, 12.03]

3 Proportion of subjects experiencing dizziness (6 months) Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.1 galantamine (8mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 galantamine (16mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 galantamine (24mg/d bid) vs placebo

2

860

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.62 [1.04, 2.52]

3.4 galantamine (32mg/d bid) vs placebo

2

857

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.04 [1.34, 3.11]

3.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.47 [1.03, 5.90]

4 Proportion of subjects experiencing diarrhea (6 months) Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4.1 galantamine (8mg/d bid) vs placebo

1

426

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.84 [0.35, 2.01]

4.2 galantamine (16mg/d bid) vs placebo

1

565

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.14 [1.20, 3.80]

4.3 galantamine (24mg/d bid) vs placebo

3

1419

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.37 [0.91, 2.05]

4.4 galantamine (32mg/d bid) vs placebo

2

857

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.03 [1.35, 3.04]

4.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.14 [1.43, 6.89]

5 Proportion of subjects experiencing anorexia (6 months) Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 galantamine (8mg/d bid) vs placebo

1

426

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.95 [0.70, 5.47]

5.2 galantamine (16mg/d bid) vs placebo

1

565

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.06 [0.95, 4.47]

5.3 galantamine (24mg/d bid) vs placebo

3

1425

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.84 [1.24, 2.73]

5.4 galantamine (32mg/d bid) vs placebo

2

857

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.71 [2.95, 7.53]

5.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.47 [1.87, 10.68]

6 Proportion of subjects experiencing weight loss (6 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

6.1 galantamine (8mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.2 galantamine (16mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.3 galantamine (24mg/d bid) vs placebo

2

860

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.55 [2.04, 6.17]

6.4 galantamine (32mg/d bid) vs placebo

2

857

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.98 [1.63, 5.46]

7 Proportion of subjects experiencing abdominal pain (6 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

7.1 galantamine (8mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.2 galantamine (16mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.3 galantamine (24mg/d bid) vs placebo

1

425

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.59 [0.69, 3.68]

7.4 galantamine (32mg/d bid) vs placebo

1

424

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.60 [1.26, 5.33]

7.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.84 [1.05, 7.66]

8 Proportion of subjects experiencing tremor (6 months) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

8.1 galantamine (8mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.2 galantamine (16mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.3 galantamine (24mg/d bid) vs placebo

1

425

Peto Odds Ratio (Peto, Fixed, 95% CI)

5.56 [1.77, 17.50]

8.4 galantamine (32mg/d bid) vs placebo

1

424

Peto Odds Ratio (Peto, Fixed, 95% CI)

4.64 [1.15, 18.77]

9 Proportion of subjects experiencing agitation (6 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

9.1 galantamine (8mg/d bid) vs placebo

1

426

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.74 [0.92, 3.30]

9.2 galantamine (16mg/d bid) vs placebo

1

565

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.07 [0.61, 1.87]

9.3 galantamine (24mg/d bid) vs placebo

1

559

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.84 [0.47, 1.51]

9.4 galantamine (32mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.33 [0.58, 3.07]

10 Proportion of subjects experiencing headache (6 months) Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

10.1 galantamine (8mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

10.2 galantamine (16mg/d bid) vs placebo

0

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

10.3 galantamine (24mg/d bid) vs placebo

1

435

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.83 [1.32, 6.09]

10.4 galantamine (32mg/d bid) vs placebo

1

433

Peto Odds Ratio (Peto, Fixed, 95% CI)

3.31 [1.61, 6.80]

10.5 galantamine (32mg/d tds) vs placebo

1

554

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.02 [0.45, 2.30]