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Forest plot of comparison: 3 Ibuprofen 200 mg versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Figure 1

Forest plot of comparison: 3 Ibuprofen 200 mg versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 4 to 6 hours.

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Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Figure 2

Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.1 Participants with at least 50% pain relief over 4 to 6 hours.

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Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.
Figuras y tablas -
Figure 3

Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.

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Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.
Figuras y tablas -
Figure 4

Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.

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Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.
Figuras y tablas -
Figure 5

Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.

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Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 1.1

Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.
Figuras y tablas -
Analysis 1.2

Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.

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Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 3 Participants with any adverse event.
Figuras y tablas -
Analysis 1.3

Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 2.1

Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.
Figuras y tablas -
Analysis 2.2

Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.

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Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 3 Participants with any adverse event.
Figuras y tablas -
Analysis 2.3

Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 3.1

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.
Figuras y tablas -
Analysis 3.2

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.
Figuras y tablas -
Analysis 3.3

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.
Figuras y tablas -
Analysis 3.4

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size.
Figuras y tablas -
Analysis 3.5

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 6 Participants using rescue medication over 6 hours.
Figuras y tablas -
Analysis 3.6

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 6 Participants using rescue medication over 6 hours.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 7 Participants using rescue medication over 6 hours, dental surgery.
Figuras y tablas -
Analysis 3.7

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 7 Participants using rescue medication over 6 hours, dental surgery.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 8 Participants using rescue medication over 6 hours, dental surgery: formulation.
Figuras y tablas -
Analysis 3.8

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 8 Participants using rescue medication over 6 hours, dental surgery: formulation.

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Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 9 Participants with any adverse event.
Figuras y tablas -
Analysis 3.9

Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 9 Participants with any adverse event.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 4.1

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.
Figuras y tablas -
Analysis 4.2

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.
Figuras y tablas -
Analysis 4.3

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.
Figuras y tablas -
Analysis 4.4

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size.
Figuras y tablas -
Analysis 4.5

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 6 Participants using rescue medication over 6 hours.
Figuras y tablas -
Analysis 4.6

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 6 Participants using rescue medication over 6 hours.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 7 Participants using rescue medication over 6 hours, dental surgery.
Figuras y tablas -
Analysis 4.7

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 7 Participants using rescue medication over 6 hours, dental surgery.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 8 Participants using rescue medication over 6 hours, dental surgery: formulation.
Figuras y tablas -
Analysis 4.8

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 8 Participants using rescue medication over 6 hours, dental surgery: formulation.

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Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 9 Participants with any adverse event.
Figuras y tablas -
Analysis 4.9

Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 9 Participants with any adverse event.

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Comparison 5 Ibuprofen 600 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 5.1

Comparison 5 Ibuprofen 600 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 6 Ibuprofen 800 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 6.1

Comparison 6 Ibuprofen 800 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Table 1. Summary of outcomes: analgesia and use of rescue medication

Analgesia

Rescue medication

Study ID

Treatment

PI or PR

Number with 50% PR

PGE: v good or excellent

Median time to use (h)

% using

Ahlstrom 1993

(1) Ibuprofen 400 mg, n = 32

(3) Placebo n = 30

SPID 6:
(1) 188 mm

(3) 32 mm

(1) 19/32

(3) 2/30

at 6 h:

(1) 75%

(3) 17%

No data

at 6 h:

(1) 31

(3) 77

Arnold 1990

(1) Ibuprofen 400 mg, n = 15

(2) Ketoprofen 25 mg, n = 14

(3) Ketoprofen 100 mg, n = 16

(4) Placebo, n = 14

TOTPAR 6:

(1) 4.2

(4) 1.5

(1) 2/15

(4) 0/14

No usable data

Mean:

(1) 3.9

(4) 2.4

at 6 h:

(1) 67

(4) 83

Bakshi 1994

(1) Ibuprofen 400 mg, n = 80

(2) Diclofenac (dispersible) 50 mg, n = 83

(3) Placebo, n = 82

TOTPAR 6:

(1) 14.9

(3) 8.9

(1) 57/80

(3) 31/82

No usable data

Mean:

(1) 5.3

(3) 3.4

at 6 h:

(1) 28

(3) 65

Black 2002

(1) Ibuprofen 200 mg, n = 100

(2) Ibuprofen 400 mg, n = 100

(3) Ibuprofen arginate 200 mg, n = 100

(4) Ibuprofen arginate 400 mg, n = 99

(5) Placebo, n = 99

TOTPAR 6:
(1) 12.6

(2) 14.9

(3) 13.1

(4) 15.0

(5) 6.9

(1) 58/100

(2) 71/100

(3) 61/100

(4) 71/99

(5) 26/99

No usable data

(1) 4.2

(2) 5.2

(3) 4.0

(4) 4.5

(5) 1.3

No data

Cheung 2007

(1) Ibuprofen 440 mg, n = 57

(2) Celecoxib 400 mg, n = 57

(3) Placebo, n = 57

TOTPAR 6:

(1) 14.9

(3) 3.7

(1) 40/57

(3) 5/57

No data

(1) 11

(3) 1.9

at 24 h:

(1) 72

(3) 86

Cooper 1977

(1) Ibuprofen 200 mg n = 38

(2) Ibuprofen 400 mg, n = 40

(3) Aspirin 325 mg, n = 37

(4) Aspirin 650 mg, n = 37

(5) Placebo, n= 40

TOTPAR 4:

(1) 7.32

(2) 6.27

(5) 3.32

(1) 17/38

(2) 20/40

(5) 6/40

No data

No data

No data

Cooper 1982

(1) Ibuprofen 400 mg, n =38

(2) Ibuprofen 400 mg + Codeine 60 mg, n = 41

(3) Aspirin 650 mg, n = 38

(4) Aspirin 650 mg + codeine 60 mg, n = 45

(5) Codeine 60 mg, n = 41

(6) Placebo, n = 46

TOTPAR 4:

(1) 8.4

(6) 2.7

(1) 22/38

(2) 27/41

(6) 5/46

No usable data

Mean:

(1) 3.8

(6) 2.4

No data

Cooper 1988a

(1) Ibuprofen 400 mg, n = 37

(2) Ketoprofen 100 mg, n = 39

(3) Ketoprofen 25 mg, n = 42

(4) Placebo, n = 43

TOTPAR 6:

(1) 11.3

(4) 4.7

(1) 19/37

(4) 6/43

at 6 h:

(1) 12/37

(4) 2/43

(1) 4.0

(4) 3.0

at 6 h:

(1) 65

(4) 79

Cooper 1989

(1) Ibuprofen 400 mg, n = 61

(2) Paracetamol 1000 mg, n = 59

(3) Placebo, n = 64

TOTPAR 6:

(1) 13.1

(3) 4.7

(1) 37/61

(3) 9/64

at 6 h:

(1) 32/61

(3) 4/64

(1) 5.5

(3) 2.3

Mean:

(1) 4.5

(3) 3.3

at 6 h:

(1) 52

(3) 78

Cooper 1996a

(1) Ibuprofen 200 mg, n = 19

(2) Misoprostal 200 mg, n = 18

(3) Ibuprofen 200 mg + misoprostal 200 mg, n = 20

(4) Placebo, n = 13

TOTPAR 6:

(1) 5.3

(3) 5.1

(4) 1.2

(1) 3/19

(3) 3/18

(4) 0/33

No usable data

Mean:

(1) 3.0

(3) 2.8

(4) 1.8

No data

De Miguel Rivero 1997

(1) Ibuprofen arginine 400 mg, n = 36

(2) Magnesic dipyrone, 2 g (IM), n = 33

(3) Placebo, n = 34

VAS SPID 5:

(1) 187 mm

(3) 120 mm

(1) 24/36

(3) 15/34

at 5 h:

(1) 20/36

(3) 7/34

Mean:

(1) 3.5

(3) 1.8

at 5 h:

(1) 14

(3) 12

Desjardins 2002

(1) Ibuprofen 200 mg, n = 50

(2) Ibuprofen 400 mg, n = 52

(3) Ibuprofen arginine 200 mg, n = 49

(4) Ibuprofen arginine 400 mg, n = 50

(5) Placebo, n = 24

TOTPAR 6:

(1) 5.4

(2) 7.3

(3) 5.8

(4) 7.9

(5) 1.7

(1) 9/50

(2) 15/52

(3) 10/49

(4) 16/49

(5) 0/23

No data

(1) 2.6

(2) 4.0

(3) 3.0

(4) 4.0

(5) 1.5

No data

Dionne 1998

(1) S(+)‐Ibuprofen 200 mg, n = 51

(2) S(+)‐Ibuprofen 400 mg, n = 50

(3) Ibuprofen (racemic) 400 mg, n = 50

(4) Placebo, n = 25

TOTPAR 6:

(1) 13.0

(2) 14.9

(3) 11.5

(4) 3.5

(1) 31/51

(2) 35/40

(3) 26/50

(4) 2/25

No data

(1) 5.8

(2) 6.1

(3) 5.4

(4) 1.8

No data

Ehrich 1999

(1) Ibuprofen 400 mg, n = 20

(2) Rofecoxib 50 mg, n = 32

(3) Rofecoxib 500 mg, n = 20

(4) Placebo, n = 32

TOTPAR 6:

(1) 15.1

(4) 2.7

(1) 14/20

(4) 1/32

No usable data

(1) >6

(4) 1.6

No usable data

Forbes 1984

(1) Ibuprofen 400 mg, n = 28

(2) Fendosal 200 mg, n = 29

(3) Aspirin 650 mg, n = 24

(4) Placebo n = 28

TOTPAR 6:

(1) 15.8

(4) 3.8

(1) 21/28

(4) 3/28

No usable data

(1) 8.3

(4) 2.7

Mean:

(1) 8.5

(4) 4.5

at 12 h:

(1) 75

(4) 89

Forbes 1990

(1) Ibuprofen 400 mg, n = 32

(2) Ketorolac 10 mg, n = 31

(3) Ketorolac 20 mg, n = 35

(4) Paracetamol 600 mg, n = 36

(5) Paracetamol 600 mg + codeine 60 mg, n = 38

(6) Placebo, n = 34

TOTPAR 6:

(1) 10.5

(6) 1.9

(1) 15/32

(6) 0/34

No usable data

(1) 4.7

(6) 1.9

Mean:

(1) 4.6

(6) 2.9

at 6 h:

(1) 58

(6) 97

Forbes 1991a

(1) Ibuprofen 50 mg, n = 57

(2) Ibuprofen 100 mg, n = 49

(3) Ibuprofen 200 mg, n = 48

(4) Ibuprofen 100 mg + Caffeine 100 mg, n = 49

(5) Ibuprofen 200 mg + Caffeine 100 mg, n = 44

(6) Placebo n = 51

TOTPAR 6:

(1) 7.0

(2) 7.0

(3) 8.7

(4) 9.3

(5) 12.6

(6) 2.2

(1) 16/57

(2) 13/49

(3) 18/48

(4) 19/49

(5) 26/44

(6) 0/51

No usable data

Mean:

1) 4.9

(2) 4.8

(3) 5.1

(4) 5.4

(5) 6.1

(6) 3.0

at 8 h:

(1) 79

(2) 78

(3) 79

(4) 69

(5) 57

(6) 94

Forbes 1991b

(1) Ibuprofen 400 mg, n = 37

(2) Bromfenac 5 mg, n = 39

(3) Bromfenac 10 mg, n = 43

(4) Bromfenac 25 mg, n = 42

(5) Aspirin 650 mg, n = 41

(6) Placebo, n = 39

TOTPAR 6:

(1) 11.0

(6) 2.5

(1) 18/37

(6) 3/39

No usable data

(1) 6.9

(6) 1.8

Mean:

(1) 5.7

(6) 2.8

at 6 h:

(1) 42

(6) 96

at 8 h:

(1) 57

(6) 97

Forbes 1992

(1) Ibuprofen 400 mg, n = 38

(2) Bromfenac 10 mg, n = 43

(3) Bromfenac 25 mg, n = 41

(4) Bromfenac 50 mg, n = 42

(5) Bromfenac 100 mg, n = 40

(6) Aspirin 650 mg, n = 38

(7) Placebo, n = 38

TOTPAR 6:

(1) 11.8

(7) 2.1

(1) 20/38

(7) 0/38

No usable data

(1) 7.3

(7) 1.8

Mean:

(1) 6.3

(7) 2.7

at 6 h:

(1) 38

(7) 92

at 8 h:
1) 58

(7) 97

Frame 1989

(1) Ibuprofen 400 mg, n = 42

(2) Dihydrocodeine 30 mg, n = 43

(3) Placebo, n = 38

TOTPAR 5:

(1) 11.1

(3) 1.9

(1) 26/42

(3) 0/38

No data

No usable data

at 5 h:

(1) 40

(3) 89

Fricke 1993

(1) Ibuprofen 400 mg, n = 81

(2) Naproxen Na 440 mg, n = 81

(3) Placebo, n = 39

TOTPAR 6:

(1) 10.9

(3) 2.9

(1) 40/81

(3) 2/39

No usable data

(1) 6.0

(3) 1.1

at 12 h:

(1) 78

(3) No data

Gay 1996

(1) Ibuprofen 400 mg, n = 41

(2) DKP.TRIS 5 mg, n = 41

(3) DKP.TRIS 10 mg, n = 42

(4) DKP.TRIS 20 mg, n = 41

(5) Placebo, n = 39

TOTPAR 6:

(1) 13.6

(5) 5.2

(1) 26/41

(5) 7/39

No usable data

Mean:

(1) 5.04

(5) 3.65

at 6 h:

(1) 27

(5) 67

Heidrich 1985

(1) Ibuprofen 400 mg, n = 40

(2) Paracetamol 300 + codeine 30 mg, n = 40

(3) Placebo, n = 40

VAS TOTPAR 6:

(1) 234 mm

(3) 104 mm

(1) 15/40

(3) 5/40

No data

No data

No data

Hersch 1993a

(1) Ibuprofen 200 mg, n = 51

(2) Ibuprofen 400 mg, n = 49

(3) Meclofenamate 100 mg, n = 52

(4) Meclofenamate 50 mg, n = 51

(5) Placebo, n = 51

TOTPAR 6:

(1) 10.3

(2) 8.0

(5) 1.7

(1) 17/51

(2) 22/49

(5) 0/51

at 8 h:

(1) 24/51

(2) 14/49

(5) 6/51

Mean:

(1) 3.1

(2) 4.2

(5) 1.5

at 8 h:

(1) 94

(2) 94

(5) 98

Hersch 1993b

(1) Ibuprofen 400 mg, n = 12

(2) Codeine 60 mg, n = 16

(3) Placebo, n = 16

TOTPAR 6:

(1) 15.7

(3) 9.0

(1) 9/12

(3) 6/16

No usable data

Mean:

(1) 5.0

(3) 4.0

No data

Hersh 2000

(1) Ibuprofen liquigel 200 mg, n = 61

(2) Ibuprofen liquigel 400 mg, n = 59

(3) Paracetamol 1000 mg, n = 63

(4) Placebo, n = 27

TOTPAR 6:

(1) 14.7

(2) 16.6

(4) 5.2

(1) 43/61

(2) 47/59

(4) 5/27

at 6 h:

(1) 38/61

(2) 41/59

(4) 4/27

(1) > 6

(2) > 6

(4) 1.6

at 6 h:

(1) 31

(2) 23

(4) 75

Hill 2001

(1) Ibuprofen 400 mg, n = 49

(2) Pregabalin 50 mg, n = 49

(3) Pregabalin 300 mg, n = 50

(4) Placebo, n = 50

TOTPAR 6:

(1) 10.1

(4) 3.8

(1) 22/49

(4) 5/50

No usable data

(1) 4.1

(4) 2.0

at 6 h:

(1) 61

(4) 81

Jain 1986

(1) Ibuprofen 100 mg, n = 39

(2) Ibuprofen 200 mg, n = 47

(3) Ibuprofen 400 mg, n = 49

(4) Aspirin 650 mg, n = 45

(5) Placebo, n = 47

SPID 6:

(1) 1.5

(2) 2.3

(3) 3.0

(5) ‐1.7

(1) 3/39

(2) 7/47

(3) 9/49

(5) 0/47

No usable data

Mean:

(1) 3.9

(2) 4.2

(3) 4.0

(5) 2.1

at 6 h:

(1) 74

(2) 67

(3) 59

(5) 96

Jain 1988

(1) Ibuprofen 400 mg, n = 49

(2) Ibuprofen 200 mg + caffeine 100 mg, n = 50

(3) Placebo, n = 48

TOTPAR 6:

(1) 14.4

(2) 13.9

(3) 8.6

(1) 33/49

(2) 33/50

(3) 17/48

No usable data

No data

at 6 h:

(1) 20

(2) 24

(3) 49

Johnson 1997

(1) Ibuprofen 400 mg, n = 48

(2) Paracetamol 650 mg + oxycodone 10 mg, n = 47

(3) Bromfenac 100 mg, n = 48

(4) Bromfenac 50 mg, n = 47

(5) Placebo, n = 48

TOTPAR 6:

(1) 7.7

(5) 5.5

(1) 15/48

(5) 9/48

No usable data

(1) 3.4

(5) 2.7

at 6 h:

(1) 79

(5) 89

Kiersch 1993

(1) Ibuprofen 200 mg, n = 81

(2) Naproxen Na 220 mg, n = 80

(3) Placebo, n = 42

TOTPAR 6:

(1) 10.3

(3) 3.7

(1) 37/81

(3) 4/42

at 12 h:

(1) 34/81

(3) 4/42

(1) 8.0

(3) 2.0

at 12 h:

(1) 63

(3) 90

Laska 1986

(1) Ibuprofen 400 mg, n = 39

(2) Ibuprofen 600 mg, n = 36

(3) Ibuprofen 800 mg, n = 39

(4) Aluminium ibuprofen 400 mg, n = 39

(5) Placebo, n = 37

SPID 6:

(1) 13.9

(2) 14.1

(3) 13.4

(5) 5.3

(1) 39/39

(2) 36/36

(3) 39/39

(5) 14/37

No data

No data

No usable data

Laveneziana 1996

(1) Ibuprofen arginine soluble 400 mg, n = 42

(2) Ketorolac 30 mg, n = 41

(3) Placebo, n = 41

VAS SPID 6:

(1) 233 mm

(3) 204 mm

(1) 29/42

(3) 24/41

No usable data

(1) 1.2

(3) 1.2

at 6 h:

(1) 36

(3) 41

Malmstrom 1999

(1) Ibuprofen 400 mg, n = 46

(2) Rofecoxib 50 mg, n = 90

(3) Celecoxib 200 mg, n = 91

(4) Placebo, n = 45

TOTPAR 6:

(1) 15.2

(4) 3.7

(1) 33/46

(4) 4/45

No usable data

(1) 8.9

(4) 1.5

at 24 h:

(1) 76

(4) 91

Malmstrom 2002

(1) Ibuprofen 400 mg, n = 45

(2) Rofecoxib 50 mg, n = 151

(3) Celecoxib 400 mg, n = 151

(4) Celecoxib 200 mg, n = 90

(5) Placebo, n = 45

TOTPAR 6:

(1) 11.7

(5) 1.0

(1) 24/45

(5) 0/45

No usable data

(1) 10.0

(5) 1.6

at 24 h:

(1) 87

(5) 98

Malmstrom 2004

(1) Ibuprofen 400 mg, n = 48

(2) Etoricoxib 60 mg, n = 75

(3) Etoricoxib 120 mg, n = 76

(4) Etoricoxib 180 mg, n = 74

(5) Etoricoxib 240 mg, n = 76

(6) Placebo, n = 49

TOTPAR 6:

(1) 14.1

(6) 3.4

(1) 32/48

(6) 4/49

No usable data

(1) 10.1

(6) 2.1

at 24 h:

(1) 81

(6) 82

McQuay 1996

(1) Ibuprofen 200 mg, n = 31

(2) Ibuprofen 400 mg, n = 30

(3) Ibuprofen 200 mg + caffeine 50 mg, n = 30

(4) Ibuprofen 200 mg + caffeine 100 mg, n = 30

(5) Ibuprofen 200 mg + caffeine 200 mg, n = 29

(6) Placebo, n = 11

TOTPAR 6:

(1) 3.0

(2) 7.0

(3) 10.3

(4) 9.5

(5) 5.5

(6) 0

(1) 2/31

(2) 6/30

(3) 8/30

(4) 14/30

(5) 12/29

(6) 0/11

No usable data

No data

No data

Medve 2001

(1) Ibuprofen 200 mg, n = 240

(2) Tramadol 37.5 mg, n = 238

(3) Paracetamol 325 mg, n = 240

(4) Tramadol 37.5 mg + paracetamol 325 mg, n = 240

(5) Placebo, n = 239

Data taken from IPMA:

(1) 114/240

(5) 5/239

No usable data

(1) 5.4

(5) 2.0

No data

Mehlisch 1990

(1) Ibuprofen 400 mg, n = 306

(2) Paracetamol 1000 mg, n = 306

(3) Placebo, n = 85

SPID 6:

(1) 5.8

(3) 1.2

(1) 124/306

(3) 5/85

No data

No data

at 6 h:

(1) 41

(3) 75

Mehlisch 1995

(1) Ibuprofen lysine 400 mg, n = 98

(2) Paracetamol 1000 mg, n = 101

(3) Placebo, n = 40

TOTPAR 6:

(1) 14.4

(3) 2.6

(1) 67/98

(3) 1/40

at 6 h:

(1) 65/98

(3) 1/40

(1) > 6

(3) 1.4

at 6 h:

(1) 26

(3) 88

Mehlisch 2002

(1) Ibuprofen 200 mg, n = 100

(2) Ibuprofen 400 mg, n = 100

(3) Ibuprofen arginine 200 mg, n = 100

(4) Ibuprofen arginine 400 mg, n = 100

(5) Placebo, n = 100

TOTPAR 6:

(1) 10.0

(2) 12.4

(3) 13.6

(4) 13.3

(5) 4.5

(1) 44/100

(2) 57/100

(3) 64/100

(4) 62/100

(5) 13/100

(1) 3.8

(2) 4.2

(3) 4.5

(4) 4.4

(5) 2.3

at 4 h:

(1) 32

(2) 47

(3) 27

(4) 33

(5) No data

Morrison 1999

(1) Ibuprofen 400 mg, n = 51

(2) Rofecoxib 50 mg, n = 50

(3) Placebo, n = 50

TOTPAR 6:

(1) 9.3

(3) 4.2

(1) 20/51

(3) 6/50

No usable data

(1) 6.1

(3) 2.4

at 24 h:

(1) 82

(3) 92

Nelson 1994

(1) Ibuprofen lysine 200 mg, n = 77

(2) Aspirin 500 mg, n = 65

(3) Placebo, n = 40

TOTPAR 6:

(1) 12.3

(3) 5.6

(1) 44/77

(3) 8/40

at 6 h:

(1) 39/77

(3) 6/40

(1) >6

(3) 2.9

at 6 h:

(1) 44

(3) 70

Nørholt 1998

(1) Ibuprofen 400 mg, n = 26

(2) Placebo, n = 31

TOTPAR 4:

(1) 11.7

(2) 4.5

(1) 22/26

(2) 8/31

No data

No data

at 4 h:

(1) 15

(2) 71

Olson 2001

(1) Ibuprofen liquigel 400 mg, n = 67

(2) Ketoprofen 25 mg, n = 67

(3) Paracetamol 1000 mg, n = 66

(4) Placebo, n = 39

TOTPAR 6:

(1) 17.4

(4) 4.3

(1) 57/67

(4) 5/39

at 6 h:

(1) 52/67

(4) 4/49

(1) > 6

(4) 1.3

at 6 h:

(1) 21

(4) 79

Pagnoni 1996

(1) Ibuprofen arginine soluble 400 mg, n = 30

(2) Ketorolac (IM) 30 mg, n = 30

(3) Placebo, n = 32

VAS SPID 6:

(1) 279

(3) 114

(1) 13/30

(3) 5/32

at 6 h:

(1) 5/30

(3) 0/32

(1) 2.1

(3) 1.9

at 6 h:

(1) 43

(3) 66

Parker 1986

(1) Ibuprofen syrup 600 mg, n = 44

(2) Aspirin syrup 600 mg, n = 33

(3) Placebo, n = 33

TOTPAR 4:

(1) 10.4

(3) 8.8

(1) 33/44

(3) 20/33

No data

No data

No data

Schachtel 1989

(1) Ibuprofen 400 mg, n = 36

(2) Paracetamol 1000 mg, n = 37

(3) Placebo, n = 38

TOTPAR 4:

(1) 10.4

(3) 5.5

(1) 27/36

(3) 13/38

No data

No data

at 4 h:

(1) 22

(3) 58

Schou 1998

(1) Ibuprofen 50 mg, n = 51

(2) Ibuprofen 100 mg, n = 53

(3) Ibuprofen 200 mg, n = 49

(4) Ibuprofen 400 mg, n = 49

(5) Placebo, n = 56

TOTPAR 6:

(1) 11.8

(2) 11.2

(3) 15.5

(4) 17.2

(5) 7.3

(1) 27/51

(2) 27/53

(3) 36/49

(4) 41/49

(5) 16/56

No data

(1) 5.5

(2) >6

(3) >6

(4) >6

(5) 3.7

Up to 6 h:

(1) 54

(2) 48

(3) 36

(4) 16

(5) 66

Schwartz 2007

(1) Ibuprofen 400 mg, n = 15

(2) MK‐0703 12.5 mg, n = 31

(3) MK‐0703 50 mg, n = 28

(4) MK‐0703 100 mg, n = 31

(5) Placebo, n = 16

No data

Not available

at 8 h:

(1) 5/15

(5) 0/16

(1) 7.1

(5) 1.6

at 8 h:

(1) 80

(5) 100

Seymour 1991 (study 1)

(1) Ibuprofen tablets 400 mg, n = 31

(2) Ibuprofen liquid in gelatin capsules 400 mg, n = 32

(3) Placebo n = 32

VAS SPID 6:

(1) 243 mm

(2) 233 mm

(3) 120 mm

(1) 20/31

(2) 22/32

(3) 10/32

No usable data

Mean:

(1) 3.6

(2) 3.5

(3) 2.1

at 6 h:

(1) 39

(2) 44

(3) 69

Seymour 1991 (study 2)

(1) Ibuprofen tablets 400 mg, n = 30

(2) Ibuprofen soluble 400 mg, n = 32

(3) Placebo, n = 30

VAS SPID 6:

(1) 214 mm

(2) 228 mm

(3) 86 mm

(1) 20/30

(2) 8/30

(3) 7/30

No usable data

Mean:

(1) 3.24

(2) 3.15

(3) 1.40

at 6 h:

(1) 60

(2) 72

(3) 93

Seymour 1996

(1) Ibuprofen tablets 200 mg, n = 18

(2) Ibuprofen soluble 200 mg, n = 17

(3) Ibuprofen tablets 400 mg, n = 15

(4) Ibuprofen soluble 400 mg, n = 16

(5) Ibuprofen tablets 600 mg, n = 17

(6) Ibuprofen soluble 600 mg, n = 17

(7) Placebo, n = 19

VAS SPID 6:

(1) 230 mm

(2) 148 mm

(3) 258 mm

(4) 238 mm

(5) 140 mm

(6) 198 mm

(7) 44 mm

(1) 7/18

(2) 9/17

(3) 11/15

(4) 11/16

(5) 11/17

(6) 8/17

(7) 2/19

No usable data

(1) 3.0

(2) 1.6

(3) 2.8

(4) 2.1

(5) 2.0

(6) 1.5

(7) 0.8

at 6 h:

(1) 88

(2) 88

(3) 67

(4) 81

(5) 100

(6) 88

(7) 100

Seymour 1998

(1) Ibuprofen 400 mg, n = 76

(2) Aceclofenac 150 mg, n = 71

(3) Placebo, n = 70

VAS TOTPAR 4:

(1) 151 mm

(3) 46 mm

(1) 27/76

(3) 3/70

No usable data

(1) 3.5

(3) 1.6

at 6 h:

(1) 55

(3) 86

Seymour 1999

(1) Ibuprofen 400 mg, n = 41

(2) WAG 994 1 mg, n = 42

(3) Placebo, n = 39

TOTPAR 6:

(1) 10.4

(3) 5.1

(1) 19/41

(3) 7/39

No usable data

(1) 5.2

(3) 2.0

at 6 h:

(1) 56

(3) 100

Seymour 2000

(1) Ibuprofen 200 mg, n = 59

(2) Buffered ketoprofen 12.5 mg, n = 61

(3) Placebo, n = 60

TOTPAR 6:

(1) 6.4

(3) 4.1

(1) 14/59

(3) 7/60

No usable data

(1) 2.0

(3) 1.9

at 6 h:

(1) 83

(3) 98

Singla 2005

(1) Ibuprofen 400 mg, n = 175

(2) Ibuprofen 400 mg + oxycodone 5 mg, n = 169

(3) Oxycodone 5 mg, n = 52

(4) Placebo, n = 60

TOTPAR 6:

(1) 10.0

(4) 6.4

(1) 77/175

(4) 14/60

No usable data

(1) 4.0

(4) 2.3

at 6 h:

(1) 71

(4) No data

Sunshine 1983

(1) Ibuprofen 400 mg, n = 30

(2) Aspirin 600 mg, n = 30

(3) Zomepirac 100 mg, n = 30

(4) Placebo, n = 30

SPID 4:

(1) 6.0

(4) 1.0

(1) 21/30

(4) 3/30

No data

No data

at 4 h:

(1) 0

(4) 17

Sunshine 1987

(1) Ibuprofen 400 mg, n = 38

(2) Ibuprofen 200 mg + codeine 30 mg, n = 40

(3) Ibuprofen 400 mg + codeine 60 mg, n = 40

(4) Codeine 60 mg, n = 37

(5) Placebo, n = 40

SPID 4:

(1) 4.8

(5) 3.4

(1) 16/38

11/40

No usable data

No usable data

at 4 h:

(1) 13

(5) 50

Sunshine 1996

(1) Ibuprofen 50 mg, n = 51

(2) Ibuprofen 100 mg, n = 51

(3) Ibuprofen 200 mg, n = 50

(4) Ibuprofen 100 mg + caffeine 100 mg, n = 50

(5) Ibuprofen 200 mg + caffeine 100 mg, n = 50

(6) Placebo, n = 50

TOTPAR 6:

(1) 4.7

(2) 8.2

(3) 13.9

(4) 10.9

(5) 14.9

(6) 2.2

(1) 7/51

(2) 17/51

(3) 33/50

(4) 24/50

(5) 36/50

(6) 0/50

No usable data

No data

at 6 h:

(1) 4

(2) 0

(3) 0

(4) 0

(5) 2

(6) 32

Sunshine 1997

(1) Ibuprofen 400 mg, n = 40

(2) Ibuprofen 400 mg + hydrocodone 15 mg, n = 40

(3) Placebo, n = 39

TOTPAR 6:

(1) 9.7

(3) 2.7

(1) 17/40

(3) 1/39

No usable data

No usable data

at 6 h:

(1) 25

(3) 82

Sunshine 1998

(1) Ibuprofen 200 mg, n = 35

(2) Ketoprofen 6.25 mg, n = 35

(3) Ketoprofen 12.5 mg, n = 35

(4) Ketoprofen 25 mg, n = 35

(5) Placebo, n = 35

TOTPAR 6:

(1) 12.5

(5) 3.6

(1) 20/35

(5) 3/35

No usable data

No usable data

No usable data

Unpublished from Edwards 2002

(1) Ibuprofen 400 mg, n = 339

(2) Placebo, n = 339

Individual patient meta‐analysis

(1) 145/339

(2) 11/339

No usable data

No usable data

at 8 h:

(1) 43/339

(2) 121/337

Van Dyke 2004

(1) Ibuprofen 400 mg, n = 186

(2) Ibuprofen 400 mg + oxycodone 5 mg, n = 187

(3) Oxycodone 5 mg, n = 63

(4) Placebo, n = 62

TOTPAR 6:

(1) 12.9

(4) 4.8

(1) 112/186

(4) 9/62

No usable data

1) > 6

(4) 2.0

at 6 h:

(1) 38

(4) 84

Wahl 1997

(1) Ibuprofen lysinate 342 mg (= 200 mg Ibu), n = 74

(2) Paracetamol 200 mg + aspirin 250 mg + caffeine 50 mg, n = 73

(3) Placebo, n = 42

TOTPAR 6:

(1) 11.6

(3) 2.5

(1) 39/74

(3) 1/42

No usable data

No data

at 6 h:

(1) 42

(3) 81

Wideman 1999 (study 1)

(1) Ibuprofen 200 mg, n = 60

(2) Ibuprofen 200 mg, + hydrocodone 7.5 mg, n = 59

(3) Hydrocodone 7.5 mg, n = 61

(4) Placebo, n = 60

TOTPAR 6:

(1) 4.9

(4) 3.5

(1) 9/60

(4) 5/60

No data

No data

No data

Wideman 1999 (study 2)

(1) Ibuprofen 400 mg, n = 50

(2) Ibuprofen 400 mg + hydrocodone 15 mg, n = 50

(3) Hydrocodone 15 mg, n = 50

(4) Placebo, n = 51

TOTPAR 6:

(1) 9.7

(4) 3.0

(1) 21/50

(4) 3/51

No data

(1) 4.2

(4) 1.8

at 8 h:

(1) 69

(4) 100

Zelenakas 2004

(1) Ibuprofen 400 mg, n = 51

(2) Lumiracoxib 100 mg, n = 51

(3) Lumiracoxib 400 mg, n = 50

(4) Placebo, n = 50

TOTPAR 6:

(1) 11.6

(4) 4.2

(1) 27/51

(4) 6/50

No usable data

(1) ˜8

(4) ˜2

at 12 h:

(1) 73

(4) 92
Figuras y tablas -
Table 1. Summary of outcomes: analgesia and use of rescue medication
Ir a la tabla de la revisión
Table 2. Summary of outcomes: adverse events and withdrawals

Adverse events

Withdrawals

Study ID

Treatment

Any

Serious

Adverse event

Other

Ahlstrom 1993

(1) Ibuprofen 400 mg, n = 32

(2) Diclofenac (drinkable) 50 mg, n = 35

(3) Placebo n = 30

at 6 h:

(1) 3/32

(3) 2/30

None

None

30 excluded for various protocol violations

Arnold 1990

(1) Ibuprofen 400 mg, n = 15

(2) Ketoprofen 25 mg, n = 14

(3) Ketoprofen 100 mg, n = 16

(4) Placebo, n = 14

at 6 h:

(1) 6/15

(4) 3/14

None

None

No data

Bakshi 1994

(1) Ibuprofen 400 mg, n = 80

(2) Diclofenac (dispersible) 50 mg, n = 83

(3) Placebo, n = 82

at 6 h:

(1) 6/80

(3) 5/82

None

None

12 exclusions: 9 with insufficient baseline pain, 2 remedicated early, 1 completed diary incorrectly

Black 2002

(1) Ibuprofen 200 mg, n = 100

(2) Ibuprofen 400 mg, n = 100

(3) Ibuprofen arginate 200 mg, n = 100

(4) Ibuprofen arginate 400 mg, n = 99

(5) Placebo, n = 99

at 6 h:

(1) 31/100

(2) 41/100

(3) 51/100

(4) 36/99

(5) 48/99

(3) 1/100 (dysphagia and pharyngitis after 60 min assessment)

(3) 1/100

4 exclusions from efficacy analysis: 2 from Ibu Arg groups vomited soon after taking drug, 1 ibu arg 200 mg and 1 placebo took prohibited medication

Cheung 2007

(1) Ibuprofen 440 mg, n = 57

(2) Celecoxib 400 mg, n = 57

(3) Placebo, n = 57

at 24 h:

(1) 35/57

(3) 39/57

None

(3) 3/57 (vomiting and anxiety)

(3) 1/57 (withdrew consent)

Cooper 1977

(1) Ibuprofen 200 mg n = 38

(2) Ibuprofen 400 mg, n = 40

(3) Aspirin 325 mg, n = 37

(4) Aspirin 650 mg, n = 37

(5) Placebo, n = 40

No data

None

None

Exclusions: 17 provided uninterpretable data, 12 took confounding medication, 10 were lost to follow up, 9 did not need medication, 5 fell asleep

Cooper 1982

(1) Ibuprofen 400 mg, n =38

(2) Ibuprofen 400 mg + Codeine 60 mg, n = 41

(3) Aspirin 650 mg, n = 38

(4) Aspirin 650 mg + codeine 60 mg, n = 45

(5) Codeine 60 mg, n = 41

(6) Placebo, n = 46

at 4 h:

(1) 11/38

(6) 5/46

None

None

Exclusions: 30 were lost to follow up, 15 did not need medication, 11 remedicated early, 6 missed more the 1 evaluation, 3 medicated with slight pain, 1 did not take all the medication, 1 medicated over 24 hrs after surgery

Cooper 1988a

(1) Ibuprofen 400 mg, n = 37

(2) Ketoprofen 100 mg, n = 39

(3) Ketoprofen 25 mg, n = 42

(4) Placebo, n = 43

at 6 h:

(1) 10/40

(4) 7/45

None reported

None reported

Exclusions: 20 did not need medication, 13 were lost to follow up, 7 had various protocol violations

Cooper 1989

(1) Ibuprofen 400 mg, n = 61

(2) Paracetamol 1000 mg, n = 59

(3) Placebo, n = 64

at 6 h:

(1) 5/63

(3) 7/64

None

None

Exclusions: 2 were lost to follow up, 2 did not need medication, 4 missed more than 1 evaluation, 1 had insufficient baseline pain, 1 failed to complete the diary at the appropriate time

Cooper 1996a

(1) Ibuprofen 200 mg, n = 19

(2) Misoprostal 200 mg, n = 18

(3) Ibuprofen 200 mg + misoprostal 200 mg, n = 20

(4) Placebo, n = 13

No usable data

All transient and mild

None reported

No data

No data

De Miguel Rivero 1997

(1) Ibuprofen arginine 400 mg, n = 36

(2) Magnesic dipyrone, 2 g (IM), n = 33

(3) Placebo, n = 34

at 5 h:

(1) 1/36

(3) 1/34

None

None

Exclusions: 3 did not need medication

Desjardins 2002

(1) Ibuprofen 200 mg, n = 50

(2) Ibuprofen 400 mg, n = 52

(3) Ibuprofen arginine 200 mg, n = 49

(4) Ibuprofen arginine 400 mg, n = 50

(5) Placebo, n = 24

at 6 h:

(1) 4/50

(2) 4/52

(3) 3/49

(4) 7/50

(5) 1/24

None

None

Exclusions from efficacy analysis: 1 (placebo) for protocol violation, 1 (placebo) for vomiting after receiving study drug and 1 (Ibu arg 400) for having a seizure 11 hours post‐dose

Dionne 1998

(1) S(+)‐Ibuprofen 200 mg, n = 51

(2) S(+)‐Ibuprofen 400 mg, n = 50

(3) Ibuprofen (racemic) 400 mg, n = 50

(4) Placebo, n = 25

No usable data

None reported

None

Exclusions: 4 had neither partial or bony impaction, 1 remedicated early

Ehrich 1999

(1) Ibuprofen 400 mg, n = 20

(2) Rofecoxib 50 mg, n = 32

(3) Rofecoxib 500 mg, n = 20

(4) Placebo, n = 32

No usable data

Any events mild and transient

None

No data

No data

Exclusions: 2 remedicated early

Forbes 1984

(1) Ibuprofen 400 mg, n = 28

(2) Fendosal 200 mg, n = 29

(3) Aspirin 650 mg, n = 24

(4) Placebo n = 28

at 12 h:

(1) 5/29

(4) 3/30

All transitory and did not require treatment

None

None

Exclusions: 2 remedicated early, 2 remedicated with some pain relief, 2 took rescue medication not test drug

Forbes 1990

(1) Ibuprofen 400 mg, n = 32

(2) Ketorolac 10 mg, n = 31

(3) Ketorolac 20 mg, n = 35

(4) Paracetamol 600 mg, n = 36

(5) Paracetamol 600 mg + codeine 60 mg, n = 38

(6) Placebo, n = 34

at 6 h:

(1) 8/43

(6) 0/38

All transitory and did not require treatment

None

None

Exclusions; 3 were lost to follow up, 1 lost report card, 27 remedicated early or while still experiencing some pain relief from study medication, 7 failed to follow instructions, 3 did not complete the forms

Forbes 1991a

(1) Ibuprofen 50 mg, n = 57

(2) Ibuprofen 100 mg, n = 49

(3) Ibuprofen 200 mg, n = 48

(4) Ibuprofen 100 mg + Caffeine 100 mg, n = 49

(5) Ibuprofen 200 mg + Caffeine 100 mg, n = 44

(6) Placebo n = 51

at 8 h:

(1) 10/63

(2) 5/62

(3) 6/60

(4) 12/58

(5) 8/58

(6) 8/61

All transitory and did not require treatment

None

None

Exclusions from efficacy analysis: 33 did not need medication, 14 remedicated early, 1 ate caffeine containing food, 2 medicated for a headache, 1 rated only one side of mouth, 1 form completed by relative, 3 lacked consistency, 22 evaluated at incorrect time, 3 incomplete forms

Forbes 1991b

(1) Ibuprofen 400 mg, n = 37

(2) Bromfenac 5 mg, n = 39

(3) Bromfenac 10 mg, n = 43

(4) Bromfenac 25 mg, n = 42

(5) Aspirin 650 mg, n = 41

(6) Placebo, n = 39

at 8 h:

(1) 7/43

(6) 3/47

All transitory and did not require treatment

None

None

Exclusions: 7 were lost to follow up, 12 did not need medication, 24 remedicated early or while still experiencing some pain relief from study medication, 2 lacked consistency, 1 did not complete the form, 1 took only part of the med

Forbes 1992

(1) Ibuprofen 400 mg, n = 38

(2) Bromfenac 10 mg, n = 43

(3) Bromfenac 25 mg, n = 41

(4) Bromfenac 50 mg, n = 42

(5) Bromfenac 100 mg, n = 40

(6) Aspirin 650 mg, n = 38

(7) Placebo, n = 38

at 8 h:

(1) 4/45

(7) 2/46

All transitory and did not require treatment

None

None

Exclusions; 3 did not return form, 14 did not need medication, 28 remedicated early or while still experiencing some pain relief from study medication, 2 lacked consistency, 2 did not complete form, 2 took only part of medication, 5 took back up medication, 2 evaluated at incorrect time

Frame 1989

(1) Ibuprofen 400 mg, n = 42

(2) Dihydrocodeine 30 mg, n = 43

(3) Placebo, n = 38

at 5 h:

(1) 4/42

(3) 3/38

None reported

(3) 1/38 (postoperative bleed)

Exclusions: 9 did not take the medication, 7 were lost to follow up, 1 was asleep so did not complete the forms, 1 had postoperative complications so did not complete the form

Fricke 1993

(1) Ibuprofen 400 mg, n = 81

(2) Naproxen Na 440 mg, n = 81

(3) Placebo, n = 39

at 12 h:

(1) 8/81

(3) 1/39

None

(1) 1/81 (soreness and swelling at 8 hrs)

Exclusions: 5 did not need medication, 1 took study medication twice ‐ excluded from efficacy analysis

Gay 1996

(1) Ibuprofen 400 mg, n = 41

(2) DKP.TRIS 5 mg, n = 41

(3) DKP.TRIS 10 mg, n = 42

(4) DKP.TRIS 20 mg, n = 41

(5) Placebo, n = 39

at 6 h:

(1) 3/41

(5) 4/41

None

None

Exclusion from efficacy analysis: 2 remedicated early

Heidrich 1985

(1) Ibuprofen 400 mg, n = 40

(2) Paracetamol 300 + codeine 30 mg, n = 40

(3) Placebo, n = 40

No usable data

Overall occurrence ±15%, no difference between groups

None reported

None

No data

Hersch 1993a

(1) Ibuprofen 200 mg, n = 51

(2) Ibuprofen 400 mg, n = 49

(3) Meclofenamate 100 mg, n = 52

(4) Meclofenamate 50 mg, n = 51

(5) Placebo, n = 51

at 8 h:

(1) 6/49

(2) 4/51

(5) 9/51

All transitory and did not require treatment

None reported

None

No data

Hersch 1993b

(1) Ibuprofen 400 mg, n = 12

(2) Codeine 60 mg, n = 16

(3) Placebo, n = 16

No data

None reported

None reported

Exclusions: 19 lost to follow up, 11 did not need medication, 3 excluded for various protocol violations

Hersh 2000

(1) Ibuprofen liquigel 200 mg, n = 61

(2) Ibuprofen liquigel 400 mg, n = 59

(3) Paracetamol 1000 mg, n = 63

(4) Placebo, n = 27

at 6 h:

(1) 7/61

(2) 4/59

(4) 7/27

None

None

None

Hill 2001

(1) Ibuprofen 400 mg, n = 49

(2) Pregabalin 50 mg, n = 49

(3) Pregabalin 300 mg, n = 50

(4) Placebo, n = 50

at 12 h:

(1) 6/49

(4) 8/50

None

None

None

Jain 1986

(1) Ibuprofen 400 mg, n = 49

(2) Ibuprofen 200 mg, n = 47

(3) Ibuprofen 100 mg, n = 39

(4) Aspirin 650 mg, n = 45

(5) Placebo, n = 47

at 6 h:

(1) 10/49

(2) 6/47

(3) 13/39

(5) 12/47

None reported

None reported

None

Jain 1988

(1) Ibuprofen 400 mg, n = 49

(2) Ibuprofen 200 mg + caffeine 100 mg, n = 50

(3) Placebo, n = 48

at 6 h:

(1) 2/49

(2) 5/50

(3) 1/48

None reported

None reported

Exclusions: 11 remedicated early, 2 received confounding agents, 1 was under 18 yrs old

Johnson 1997

(1) Ibuprofen 400 mg, n = 48

(2) Paracetamol 650 mg + oxycodone 10 mg, n = 47

(3) Bromfenac 100 mg, n = 48

(4) Bromfenac 50 mg, n = 47

(5) Placebo, n = 48

No usable data

CNS AEs at 8 h:

(1) 5/48

(5) 2/48

None reported

None reported

Exclusions: 2 had invalid data

Kiersch 1993

(1) Ibuprofen 200 mg, n = 81

(2) Naproxen Na 220 mg, n = 80

(3) Placebo, n = 42

at 12 h:

(1) 16/81

(3) 5/43

None

(1) 1/81

Exclusions: 2 had protocol violations

Laska 1986

(1) Ibuprofen 400 mg, n = 39

(2) Ibuprofen 600 mg, n = 36

(3) Ibuprofen 800 mg, n = 39

(4) Aluminium ibuprofen 400 mg, n = 39

(5) Placebo, n = 37

at 6 h:

(1) 0/39

(2) 1/36

(3) 0/39

(4) 1/39

(5) 3/37

None reported

None

Exclusions: 4 remedicated early, 1 vomited within 5 mins of taking the study medication. 4 with moderate pain dropped to keep populations homogeneous (author letter)

Laveneziana 1996

(1) Ibuprofen arginine soluble 400 mg, n = 42

(2) Ketorolac 30 mg, n = 41

(3) Placebo, n = 41

None

None

None

Exclusions: 1 had insufficient pain

Malmstrom 1999

(1) Ibuprofen 400 mg, n = 46

(2) Rofecoxib 50 mg, n = 90

(3) Celecoxib 200 mg, n = 91

(4) Placebo, n = 45

No usable data

None reported

(4) 1/45 (excessive bleeding)

None

4 patients lost to follow up at post‐study visit

Malmstrom 2002

(1) Ibuprofen 400 mg, n = 45

(2) Rofecoxib 50 mg, n = 151

(3) Celecoxib 400 mg, n = 151

(4) Celecoxib 200 mg, n = 90

(5) Placebo, n = 45

at 24 h:

(1) 8/45

(5) 12/45

None

None

None

Malmstrom 2004

(1) Ibuprofen 400 mg, n = 48

(2) Etoricoxib 60 mg, n = 75

(3) Etoricoxib 120 mg, n = 76

(4) Etoricoxib 180 mg, n = 74

(5) Etoricoxib 240 mg, n = 76

(6) Placebo, n = 49

Up to 14 days:

(1) 17/48

(6) 24/49

None

(1) 1/48 (vomiting)

None

McQuay 1996

(1) Ibuprofen 200 mg, n = 31

(2) Ibuprofen 400 mg, n = 30

(3) Ibuprofen 200 mg + caffeine 50 mg, n = 30

(4) Ibuprofen 200 mg + caffeine 100 mg, n = 30

(5) Ibuprofen 200 mg + caffeine 200 mg, n = 29

(6)Placebo, n = 11

at 8 h:

(1) 4/31

(2) 1/30

(3) 2/30

(4) 0/29

(5) 2/30

(6) 1/11

None reported

None

Exclusions: 3 with protocol violations

Medve 2001

(1) Ibuprofen 200 mg, n = 240

(2) Tramadol 37.5 mg, n = 238

(3) Paracetamol 325 mg, n = 240

(4) Tramadol 37.5 mg + paracetamol 325 mg, n = 240

(5) Placebo, n = 239

No usable data

Generally transient and mild to moderate in severity

None reported

No data

No details for 3 exclusions

Mehlisch 1990

(1) Ibuprofen 400 mg, n = 306

(2) Paracetamol 1000 mg, n = 306

(3) Placebo, n = 85

at 6 h:

(1) 31/306

(3) 12/85

None reported

None

Exclusions: 4 were lost to follow up, 4 entered in the trial twice (1st entry only was analysed for efficacy but both were included in safety analysis) and 1 excluded for failing to meet inclusion criteria

Mehlisch 1995

(1) Ibuprofen lysine 400 mg, n = 98

(2) Paracetamol 1000 mg, n = 101

(3) Placebo, n = 40

at 6 h:

(1) 12/98

(3) 4/40

None

None

Exclusions: 1 failed to complete diary

Mehlisch 2002

(1) Ibuprofen 200 mg, n = 100

(2) Ibuprofen 400 mg, n = 100

(3) Ibuprofen arginine 200 mg, n = 100

(4) Ibuprofen arginine 400 mg, n = 100

(5) Placebo, n = 100

at 6 h:

(1) 28/100

(2) 27/100

(3) 27/100

(4) 26/100

(5) 27/100

None

None

Exclusions: 3 from efficacy analysis for protocol violation

Morrison 1999

(1) Ibuprofen 400 mg, n = 51

(2) Rofecoxib 50 mg, n = 50

(3) Placebo, n = 50

at 24 h:

(1) 13/51

(3) 17/50

None

None

None

Nelson 1994

(1) Ibuprofen lysine 200 mg, n = 77

(2) Aspirin 500 mg, n = 65

(3) Placebo, n = 40

at 6 h:

(1) 16/75

(3) 11/40

None

None

Exclusions: 2 remedicated early, 1 did not record baseline pain intensity

Nørholt 1998

(1) Ibuprofen 400 mg, n = 26

(2) Placebo, n = 31

No data

No data

None

None

Olson 2001

(1) Ibuprofen liquigel 400 mg, n = 67

(2) Ketoprofen 25 mg, n = 67

(3) Paracetamol 1000 mg, n = 66

(4) Placebo, n = 39

at 6 h:

(1) 7/67

(4) 2/39

None

None

None

Pagnoni 1996

(1) Ibuprofen arginine soluble 400 mg, n = 30

(2) Ketorolac (IM) 30 mg, n = 30

(3) Placebo, n = 32

None

None

None

None

Parker 1986

(1) Ibuprofen syrup 600 mg, n = 44

(2) Aspirin syrup 600 mg, n = 33

(3) Placebo, n = 33

No usable data

None reported

(3) 1/33 (probably in multiple dose phase)

Exclusions: 29 for which there is no further data

Schachtel 1989

(1) Ibuprofen 400 mg, n = 36

(2) Paracetamol 1000 mg, n = 37

(3) Placebo, n = 38

at 4 h:

None

None

None

Exclusions: 4 remedicated early

Schou 1998

(1) Ibuprofen 50 mg, n = 51

(2) Ibuprofen 100 mg, n = 53

(3) Ibuprofen 200 mg, n = 49

(4) Ibuprofen 400 mg, n = 49

(5) Placebo, n = 56

No usable data

18 patients reported mild transient AEs ‐ no details of groups

None

None

Exclusions: 46 due to insufficient baseline pain, 3 withdrew (reasons not related to AE), 5 failed to attend follow‐up, 5 lost self‐report measure, 3 took study prohibited additional analgesia, 3 did not require surgery, 2 remedicated early, 1 had concomitant surgical removal of maxillary third molar

Schwartz 2007

(1) Ibuprofen 400 mg, n = 15

(2) MK‐0703 12.5 mg, n = 31

(3) MK‐0703 50 mg, n = 28

(4) MK‐0703 100 mg, n = 31

(5) Placebo, n = 16

No usable data

38 patients in total reported AEs, no details of groups

None

None

None

Seymour 1991 (study 1)

(1) Ibuprofen tablets 400 mg, n = 31

(2) Ibuprofen liquid in gelatin capsules 400 mg, n = 32

(3) Placebo n = 32

at 6 h:

(1) 0/31

(2) 0/32

(3) 1/32

None

None

No data

Seymour 1991 (study 2)

(1) Ibuprofen tablets 400 mg, n = 30

(2) Ibuprofen soluble 400 mg, n = 32

(3) Placebo, n = 30

at 6 h:

None

None

None

No data

Seymour 1996

(1) Ibuprofen tablets 200 mg, n = 18

(2) Ibuprofen soluble 200 mg, n = 17

(3) Ibuprofen tablets 400 mg, n = 15

(4) Ibuprofen soluble 400 mg, n = 16

(5) Ibuprofen tablets 600 mg, n = 17

(6) Ibuprofen soluble 600 mg, n = 17

(7) Placebo, n = 19

No data

No data

No usable data

4 reported adverse effects, 3 had received ibuprofen (did not clarify which dose) and 1 had taken placebo

25 had inadequate baseline pain intensity

Seymour 1998

(1) Ibuprofen 400 mg, n = 76

(2) Aceclofenac 150 mg, n = 71

(3) Placebo, n = 70

at 6 h:

(1) 5/76

(3) 3/68

None reported

None reported

Exclusions: 2 patients in group 2 and 2 patients in group 3 not accounted for

Seymour 1999

(1) Ibuprofen 400 mg, n = 41

(2) WAG 994 1 mg, n = 42

(3) Placebo, n = 39

No data

None

No data

No data

Seymour 2000

(1) Ibuprofen 200 mg, n = 59

(2) Buffered ketoprofen 12.5 mg, n = 61

(3) Placebo, n = 50

at 6 h:

(1) 5/59

(3) 3/60

None

None

Exclusions: 2 remedicated early, one in Ibuprofen group and one in placebo group

Singla 2005

(1) Ibuprofen 400 mg, n = 175

(2) Ibuprofen 400 mg + oxycodone 5 mg, n = 169

(3) Oxycodone 5 mg, n = 52

(4) Placebo, n = 60

at 6 h:

(1) 74/175

(4) 33/60

None

(1) 1/175

(4) 0/60

1 patient in Ibu group excluded due to protocol violation

Sunshine 1983

(1) Ibuprofen 400 mg, n = 30

(2) Aspirin 600 mg, n = 30

(3) Zomepirac 100 mg, n = 30

(4) Placebo, n = 30

None

None

None

None

Sunshine 1987

(1) Ibuprofen 400 mg, n = 38

(2) Ibuprofen 200 mg + codeine 30 mg, n = 40

(3) Ibuprofen 400 mg + codeine 60 mg, n = 40

(4) Codeine 60 mg, n = 37

(5) Placebo, n = 40

at 4 h:

(1) 0/38

(5) 0/40

None

None

Exclusions: 1 had not complied with the washout period, 4 did not complete the evaluations

Sunshine 1996

(1) Ibuprofen 50 mg, n = 51

(2) Ibuprofen 100 mg, n = 51

(3) Ibuprofen 200 mg, n = 50

(4) Ibuprofen 100 mg + caffeine 100 mg, n = 50

(5) Ibuprofen 200 mg + caffeine 100 mg, n = 50

(6) Placebo, n = 50

at 6 h:

(1) 1/51

(2) 4/51

(3) 1/50

(4) 2/50

(5) 4/50

(6) 0/50

None

None

Exclusions: 3 for protocol violations

Sunshine 1997

(1) Ibuprofen 400 mg, n = 40

(2) Ibuprofen 400 mg + hydrocodone 15 mg, n = 40

(3) Placebo, n = 39

at 6 h:

(1) 5/40

(3) 4/40

None

None

Exclusions: One from placebo group refused to cooperate and was excluded from the study

Sunshine 1998

(1) Ibuprofen 200 mg, n = 35

(2) Ketoprofen 6.25 mg, n = 35

(3) Ketoprofen 12.5 mg, n = 35

(4) Ketoprofen 25 mg, n = 35

(5) Placebo, n = 35

Up to 6 h:

(1) 2/35

(5) 3/35

None

None

Exclusions: 2 remedicated early, 1 vomited study drug, 1 withdrew consent

Unpubl 2002

(Edwards 2002)

(1) Ibuprofen 400 mg, n = 339

(2) Placebo, n = 339

at 6 h:

(1) 41/339

(2) 58/337

None

No usable data

Total withdrawals not due to lack of efficacy

(1) 2/339

(2) 3/337

Van Dyke 2004

(1) Ibuprofen 400 mg, n = 186

(2) Ibuprofen 400 mg + oxycodone 5 mg, n = 187

(3) Oxycodone 5 mg, n = 63

(4) Placebo, n = 62

at 6 h:

(1) 20/186

(4) 7/62

None

None

Exclusions: 1 had inadequate baseline pain

(1) 1/186 no reason given

Wahl 1997

(1) Ibuprofen lysinate 342 mg (= 200 mg Ibu), n = 74

(2) Paracetamol 200 mg + aspirin 250 mg + caffeine 50 mg, n = 73

(3) Placebo, n = 42

at 6 h:

(1) 7/74

(3) 5/42

None

None

Exclusions: 12 withdrew consent, 13 did not require analgesia after surgery, 6 failed to complete their study lists, and 1 may not have taken study medication correctly

Wideman 1999 (study 1)

(1) Ibuprofen 200 mg, n = 60

(2) Ibuprofen 200 mg, + hydrocodone 7.5 mg, n = 59

(3) Hydrocodone 7.5 mg, n = 61

(4) Placebo, n = 60

at 8 h:

(1) 6/60

(4) 1/60

None

None

None

Wideman 1999 (study 2)

(1) Ibuprofen 400 mg, n = 50

(2) Ibuprofen 400 mg + hydrocodone 15 mg, n = 50

(3) Hydrocodone 15 mg, n = 50

(4) Placebo, n = 51

at 8 h:

(1) 7/50

(4) 6/51

None

None

None

Zelenakas 2004

(1) Ibuprofen 400 mg, n = 51

(2) Lumiracoxib 100 mg, n = 51

(3) Lumiracoxib 400 mg, n = 50

(4) Placebo, n = 50

at 12 h:

(1) 5/51

(4) 10/50

(1) 0/51

(4) 1/50 (deep vein thrombosis)

(1) 1/51 (postoperative bleed)

(1) 1/51 (? withdrew consent)
Figuras y tablas -
Table 2. Summary of outcomes: adverse events and withdrawals
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Comparison 1. Ibuprofen 50 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

3

316

Risk Ratio (M‐H, Fixed, 95% CI)

3.15 [1.94, 5.12]

2 Participants using rescue medication over 6 hours Show forest plot

2

208

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.44, 0.84]

3 Participants with any adverse event Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

1.31 [0.57, 3.00]
Figuras y tablas -
Comparison 1. Ibuprofen 50 mg versus placebo
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Comparison 2. Ibuprofen 100 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

4

396

Risk Ratio (M‐H, Fixed, 95% CI)

3.68 [2.29, 5.92]

2 Participants using rescue medication over 6 hours Show forest plot

3

296

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.57, 0.84]

3 Participants with any adverse event Show forest plot

3

310

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [0.71, 2.07]
Figuras y tablas -
Comparison 2. Ibuprofen 100 mg versus placebo
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Comparison 3. Ibuprofen 200 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

20

2690

Risk Ratio (M‐H, Fixed, 95% CI)

4.62 [3.85, 5.56]

2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery Show forest plot

20

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

2.1 Dental surgery

18

2470

Risk Ratio (M‐H, Fixed, 95% CI)

4.48 [3.71, 5.41]

2.2 Other surgery

2

220

Risk Ratio (M‐H, Fixed, 95% CI)

7.73 [3.24, 18.41]

3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation Show forest plot

20

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

3.1 Standard ibuprofen

17

2103

Risk Ratio (M‐H, Fixed, 95% CI)

6.11 [4.84, 7.73]

3.2 ibuprofen lysine, arginine, or soluble

7

828

Risk Ratio (M‐H, Fixed, 95% CI)

5.73 [4.15, 7.90]

4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation Show forest plot

18

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

4.1 Standard ibuprofen

15

1883

Risk Ratio (M‐H, Fixed, 95% CI)

5.98 [4.69, 7.62]

4.2 Ibuprofen lysine, arginine or soluble

7

828

Risk Ratio (M‐H, Fixed, 95% CI)

5.73 [4.15, 7.90]

5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size Show forest plot

15

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5.1 40 or more participants

11

1953

Risk Ratio (M‐H, Fixed, 95% CI)

4.56 [3.71, 5.61]

5.2 Fewer than 40 participants

4

229

Risk Ratio (M‐H, Fixed, 95% CI)

5.15 [2.41, 11.00]

6 Participants using rescue medication over 6 hours Show forest plot

8

794

Risk Ratio (M‐H, Fixed, 95% CI)

0.63 [0.57, 0.70]

7 Participants using rescue medication over 6 hours, dental surgery Show forest plot

7

694

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.60, 0.73]

8 Participants using rescue medication over 6 hours, dental surgery: formulation Show forest plot

7

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

8.1 Standard ibuprofen

4

345

Risk Ratio (M‐H, Fixed, 95% CI)

0.74 [0.66, 0.84]

8.2 Ibuprofen lysine, arginine or soluble

4

349

Risk Ratio (M‐H, Fixed, 95% CI)

0.57 [0.48, 0.68]

9 Participants with any adverse event Show forest plot

14

1808

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.71, 1.02]
Figuras y tablas -
Comparison 3. Ibuprofen 200 mg versus placebo
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Comparison 4. Ibuprofen 400 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

57

6475

Risk Ratio (M‐H, Fixed, 95% CI)

3.94 [3.58, 4.35]

2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery Show forest plot

57

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

2.1 Dental surgery

45

5428

Risk Ratio (M‐H, Fixed, 95% CI)

4.63 [4.13, 5.20]

2.2 Other surgery

12

1047

Risk Ratio (M‐H, Fixed, 95% CI)

2.18 [1.81, 2.62]

3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation Show forest plot

57

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

3.1 Standard ibuprofen

51

5604

Risk Ratio (M‐H, Fixed, 95% CI)

4.64 [4.14, 5.18]

3.2 Ibuprofen lysine, arginine or soluble

12

1124

Risk Ratio (M‐H, Fixed, 95% CI)

3.70 [3.00, 4.56]

4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation Show forest plot

45

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

4.1 Standard ibuprofen

42

4772

Risk Ratio (M‐H, Fixed, 95% CI)

5.17 [4.56, 5.87]

4.2 Ibuprofen lysine, arginine or soluble

9

959

Risk Ratio (M‐H, Fixed, 95% CI)

6.55 [4.85, 8.85]

5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size Show forest plot

29

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5.1 40 or more participants

15

3086

Risk Ratio (M‐H, Fixed, 95% CI)

4.44 [3.80, 5.19]

5.2 Fewer than 40 participants

14

856

Risk Ratio (M‐H, Fixed, 95% CI)

4.06 [3.21, 5.14]

6 Participants using rescue medication over 6 hours Show forest plot

28

2983

Risk Ratio (M‐H, Fixed, 95% CI)

0.54 [0.51, 0.57]

7 Participants using rescue medication over 6 hours, dental surgery Show forest plot

22

2554

Risk Ratio (M‐H, Fixed, 95% CI)

0.52 [0.48, 0.55]

8 Participants using rescue medication over 6 hours, dental surgery: formulation Show forest plot

21

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

8.1 Standard ibuprofen

18

1857

Risk Ratio (M‐H, Fixed, 95% CI)

0.55 [0.51, 0.59]

8.2 Ibuprofen lysine, arginine or soluble

6

449

Risk Ratio (M‐H, Fixed, 95% CI)

0.42 [0.35, 0.50]

9 Participants with any adverse event Show forest plot

36

4865

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.82, 1.04]
Figuras y tablas -
Comparison 4. Ibuprofen 400 mg versus placebo
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Comparison 5. Ibuprofen 600 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

3

203

Risk Ratio (M‐H, Fixed, 95% CI)

1.98 [1.52, 2.58]
Figuras y tablas -
Comparison 5. Ibuprofen 600 mg versus placebo
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Comparison 6. Ibuprofen 800 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

1

76

Risk Ratio (M‐H, Fixed, 95% CI)

2.59 [1.72, 3.89]
Figuras y tablas -
Comparison 6. Ibuprofen 800 mg versus placebo
Ir a la tabla de la revisión