Antagonistas de la vitamina K versus tratamiento antiplaquetario después de un accidente isquémico transitorio o un accidente cerebrovascular isquémico menor de presunto origen arterial
Información
- DOI:
- https://doi.org/10.1002/14651858.CD001342.pub3Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 12 septiembre 2012see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Accidentes cerebrovasculares
- Copyright:
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- Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Autores
Contributions of authors
Dr De Schryver and Professor Algra performed the collection of data: the screening of retrieved papers against inclusion criteria, the assessment of quality of the research, and the abstraction of the data.
Professor Algra is the guarantor of this review, and designed the review with the help of Professor van Gijn, Professor Kappelle and Professor Koudstaal.
Dr De Schryver and Professor Algra wrote to authors of the papers for additional information and unpublished data.
All authors performed the interpretation of the data.
Dr De Schryver was responsible for data management and entering the data into RevMan.
Dr De Schryver and Professor Algra analysed the data.
Professor Algra was responsible for the methodological perspective and, together with Professor van Gijn, Professor Kappelle and Professor Koudstaal, for the clinical, policy and consumer implications.
Dr De Schryver and Professor Algra wrote the review.
Professor van Gijn, Professor Kappelle and Professor Koudstaal provided general advice on the review.
Professor Algra, Professor van Gijn, Professor Kappelle and Professor Koudstaal had performed previous work which was the foundation of the current study.
Sources of support
Internal sources
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University Medical Center Utrecht, Netherlands.
External sources
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No sources of support supplied
Declarations of interest
The authors were all members of the Executive Committee of ESPRIT 2007, the European/Australian Stroke Prevention in Reversible Ischaemia Trial. All authors, except Els de Schryver, were members of the Executive Committee of SPIRIT 1997, the Stroke Prevention in Reversible Ischaemia Trial.
Ale Algra is employed by the University Medical Center Utrecht. He has received several grants for cerebrovascular research from granting bodies such as the Netherlands Heart Foundation, Nederlandse HersenStichting, TromboseStichting Nederland, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO, Netherlands Organisation for Scientific Research) and Nederlandse Organisatie voor Gezondheidsonderzoek en Zorginnovatie (ZonMW, Netherlands Organisation for Health Research and Development). In the last five years he has received speaker fees and travel expenses from Boehringer Ingelheim and Sanofi. He is one of the principal investigators of ESPRIT, the European/Australian Stroke Prevention in Reversible Ischaemia Trial, a trial that was run independently of any pharmaceutical company. After completion and full analysis of ESPRIT, the study group accepted financial support from Boehringer Ingelheim for post hoc exploratory analyses of the ESPRIT trial data in 2006. For this purpose a contract was signed in which we negotiated complete scientific freedom.
Jaap Kappelle has, in the past five years, received speaker and consulting honoraria from Boehringer Ingelheim and Bayer.
Jan van Gijn was principal investigator (with Ale Algra) of the SPIRIT Study (anticoagulants versus aspirin) ‐ no commercial interest.
Acknowledgements
We thank Hazel Fraser for providing us with a list of relevant trials from the Cochrane Stroke Group Trials Register; Brenda Thomas for developing comprehensive search strategies in EMBASE, MEDLINE and CENTRAL; and Dr AMHP van den Besselaar for his help in determining the anticoagulation levels in terms of INRs.
Version history
| Published | Title | Stage | Authors | Version |
| 2012 Sep 12 | Vitamin K antagonists versus antiplatelet therapy after transient ischaemic attack or minor ischaemic stroke of presumed arterial origin | Review | Els LLM De Schryver, Ale Algra, L Jaap Kappelle, Jan van Gijn, Peter J Koudstaal | |
| 2006 Jul 19 | Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischaemic attack or minor stroke of presumed arterial origin | Review | Ale Algra, Els LLM De Schryver, Jan van Gijn, L Jaap Kappelle, Peter J Koudstaal | |
| 2001 Oct 23 | Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischaemic attack or minor stroke of presumed arterial origin | Review | Ale Algra, Els De Schryver, Jan van Gijn, L Jaap Kappelle, Peter J Koudstaal | |
Differences between protocol and review
None
Notes
None
