| 1 Oxygen saturation measured by pulse oximetry: inpatient and outpatient settings Show forest plot | 25 | 1242 | Mean Difference (IV, Random, 95% CI) | ‐0.43 [‐0.92, 0.06] |
|
| 1.1 Inpatient studies | 12 | 495 | Mean Difference (IV, Random, 95% CI) | ‐0.62 [‐1.40, 0.16] |
| 1.2 Outpatient studies | 13 | 747 | Mean Difference (IV, Random, 95% CI) | ‐0.25 [‐0.61, 0.11] |
| 2 Sub‐analysis ‐ oxygen saturation (outpatients treated with albuterol/salbutamol) Show forest plot | 10 | 572 | Mean Difference (IV, Random, 95% CI) | ‐0.19 [‐0.59, 0.21] |
|
| 3 Improvement in clinical score (dichotomous) Show forest plot | 7 | 365 | Odds Ratio (M‐H, Random, 95% CI) | 0.18 [0.06, 0.50] |
|
| 3.1 Inpatient | 5 | 208 | Odds Ratio (M‐H, Random, 95% CI) | 0.20 [0.05, 0.79] |
| 3.2 Outpatient | 2 | 157 | Odds Ratio (M‐H, Random, 95% CI) | 0.11 [0.01, 1.46] |
| 4 Average clinical score after treatment: by treatment setting (continuous) Show forest plot | 21 | 1086 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.54, ‐0.05] |
|
| 4.1 Inpatient studies | 9 | 416 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.14 [‐0.41, 0.12] |
| 4.2 Outpatient studies | 12 | 670 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.42 [‐0.79, ‐0.06] |
| 5 Sub‐analysis ‐ average clinical score (outpatients treated with albuterol/salbutamol) Show forest plot | 9 | 532 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.36 [‐0.83, 0.11] |
|
| 6 Hospital admission after treatment (outpatients treated with albuterol or salbutamol) Show forest plot | 11 | 710 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.46, 1.21] |
|
| 6.1 Nebulized | 8 | 404 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.77 [0.44, 1.33] |
| 6.2 Oral in ED setting | 1 | 37 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.32 [0.03, 3.21] |
| 6.3 Oral at home | 2 | 269 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.86 [0.28, 2.64] |
| 7 Duration of hospitalization (inpatients) Show forest plot | 6 | 349 | Mean Difference (IV, Fixed, 95% CI) | 0.06 [‐0.27, 0.39] |
|
| 8 Time to resolution of illness (outpatients) Show forest plot | 2 | 269 | Mean Difference (IV, Fixed, 95% CI) | 0.29 [‐0.43, 1.00] |
|
| 9 Sensitivity analysis ‐ oxygen saturation low risk of bias studies Show forest plot | 15 | 793 | Mean Difference (IV, Random, 95% CI) | ‐0.38 [‐0.75, 0.00] |
|
| 9.1 Inpatient | 4 | 210 | Mean Difference (IV, Random, 95% CI) | ‐0.65 [‐1.77, 0.48] |
| 9.2 Outpatient | 11 | 583 | Mean Difference (IV, Random, 95% CI) | ‐0.29 [‐0.66, 0.08] |
| 10 Sensitivity analysis ‐ average clinical score low risk of bias studies Show forest plot | 15 | 734 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.22 [‐0.41, ‐0.03] |
|
| 10.1 Inpatient | 5 | 228 | Std. Mean Difference (IV, Random, 95% CI) | 0.01 [‐0.35, 0.37] |
| 10.2 Outpatient | 10 | 506 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.32 [‐0.54, ‐0.09] |
| 11 Sensitivity analysis ‐ average clinical score using RDAI (outpatients) Show forest plot | 4 | 240 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.11 [‐0.48, 0.25] |
|
