1 Oxygen saturation measured by pulse oximetry: inpatient and outpatient settings Show forest plot

24

1182

Mean Difference (IV, Random, 95% CI)

‐0.45 [‐0.96, 0.05]

1.1 Inpatient studies

10

426

Mean Difference (IV, Random, 95% CI)

‐0.29 [‐1.10, 0.51]

1.2 Outpatient studies

14

756

Mean Difference (IV, Random, 95% CI)

‐0.57 [‐1.13, 0.00]

2 No Improvement in clinical score (dichotomous) Show forest plot

7

365

Odds Ratio (M‐H, Random, 95% CI)

0.18 [0.06, 0.50]

2.1 Inpatient

5

208

Odds Ratio (M‐H, Random, 95% CI)

0.20 [0.05, 0.79]

2.2 Outpatient

2

157

Odds Ratio (M‐H, Random, 95% CI)

0.11 [0.01, 1.46]

3 Average clinical score after treatment: by treatment setting (continuous) Show forest plot

19

1006

Std. Mean Difference (IV, Random, 95% CI)

‐0.37 [‐0.62, ‐0.13]

3.1 Inpatient studies

8

396

Std. Mean Difference (IV, Random, 95% CI)

‐0.20 [‐0.43, 0.03]

3.2 Outpatient studies

11

610

Std. Mean Difference (IV, Random, 95% CI)

‐0.49 [‐0.86, ‐0.11]

4 Hospital admission after treatment (outpatients) Show forest plot

10

650

Odds Ratio (M‐H, Fixed, 95% CI)

0.78 [0.47, 1.29]

4.1 Nebulized

7

344

Odds Ratio (M‐H, Fixed, 95% CI)

0.81 [0.45, 1.46]

4.2 Oral in ED setting

1

37

Odds Ratio (M‐H, Fixed, 95% CI)

0.32 [0.03, 3.21]

4.3 Oral at home

2

269

Odds Ratio (M‐H, Fixed, 95% CI)

0.86 [0.28, 2.64]

5 Duration of hospitalization (inpatients) Show forest plot

6

349

Mean Difference (IV, Fixed, 95% CI)

0.06 [‐0.27, 0.39]

6 Time to resolution of illness (outpatients) Show forest plot

2

269

Mean Difference (IV, Fixed, 95% CI)

0.29 [‐0.43, 1.00]

7 Sensitivity analysis ‐ oxygen saturation Show forest plot

15

793

Mean Difference (IV, Random, 95% CI)

‐0.38 [‐0.75, 0.00]

8 Sensitivity analysis ‐ average clinical score Show forest plot

14

714

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.44, ‐0.08]