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Antibióticos para el tracoma
Jennifer R Evans, Anthony W Solomon, Rahul Kumar, Ángela Perez, Balendra P Singh, Rajat Mohan Srivastava, Emma Harding‐Esch | 25 septiembre 2019

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Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 2

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.1 Clinical remission (early).
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Figure 3

Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.1 Clinical remission (early).

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Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.2 Microbiological remission (early).
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Figure 4

Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.2 Microbiological remission (early).

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Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.3 Clinical remission (late).
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Figure 5

Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.3 Clinical remission (late).

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Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.4 Microbiological remission (late).
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Figure 6

Forest plot of comparison: 1 Antibiotics versus placebo, outcome: 1.4 Microbiological remission (late).

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Comparison 1 Antibiotics versus placebo, Outcome 1 Clinical remission (early).
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Analysis 1.1

Comparison 1 Antibiotics versus placebo, Outcome 1 Clinical remission (early).

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Comparison 1 Antibiotics versus placebo, Outcome 2 Microbiological remission (early).
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Analysis 1.2

Comparison 1 Antibiotics versus placebo, Outcome 2 Microbiological remission (early).

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Comparison 1 Antibiotics versus placebo, Outcome 3 Clinical remission (late).
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Analysis 1.3

Comparison 1 Antibiotics versus placebo, Outcome 3 Clinical remission (late).

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Comparison 1 Antibiotics versus placebo, Outcome 4 Microbiological remission (late).
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Analysis 1.4

Comparison 1 Antibiotics versus placebo, Outcome 4 Microbiological remission (late).

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Table 1. Ingredients of eye drops

Studies

Active treatment ingredient

Placebo vehicle ingredient

Abelson 2008

1% azithromycin in DuraSite

0.01% benzalkonium chloride (BAK), a potent antiseptic

Gigliotti

1984

Ointment containing polymyxin and bacitracin

Neutral ointment

Gross 2003 and Tauber

2011

0.5% moxifloxacin

No information

Karpecki 2009; Tepedino 2009; and Silverstein 2011

0.6% besifloxacin

0.01% benzalkonium chloride (BAK), a potent antiseptic

Leibowitz 1991

0.3% ciprofloxacin

No information

Miller 1992

0.3% norfloxacin

0.01% benzalkonium chloride (BAK), a potent antiseptic

Rietveld 2005

1% fusidic acid gel

Placebo gel Vidisic 2 mg/g does not contain an antiseptic

Rose 2005

0.5% chloramphenicol

Boric acid/borax ‐ also has antiseptic properties
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Table 1. Ingredients of eye drops
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Comparison 1. Antibiotics versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical remission (early) Show forest plot

6

2116

Risk Ratio (M‐H, Random, 95% CI)

1.36 [1.15, 1.61]

2 Microbiological remission (early) Show forest plot

7

1850

Risk Ratio (M‐H, Random, 95% CI)

1.55 [1.37, 1.76]

3 Clinical remission (late) Show forest plot

8

2353

Risk Ratio (M‐H, Random, 95% CI)

1.21 [1.10, 1.33]

4 Microbiological remission (late) Show forest plot

9

1456

Risk Ratio (M‐H, Random, 95% CI)

1.37 [1.24, 1.52]
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Comparison 1. Antibiotics versus placebo
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