Agentes fibrinolíticos para la oclusión arterial periférica
Appendices
Appendix 1. CENTRAL search strategy
| #1 | MeSH descriptor: [Thrombolytic Therapy] explode all trees | 1556 |
| #2 | MeSH descriptor: [Fibrinolytic Agents] this term only and with qualifiers: [Administration & dosage ‐ AD] | 596 |
| #3 | MeSH descriptor: [Plasminogen Activators] explode all trees and with qualifiers: [Administration & dosage ‐ AD] | 662 |
| #4 | urokinase or streptokinase or streptase or tenecteplase:ti,ab,kw (Word variations have been searched) | 1885 |
| #5 | reteplase or alteplase:ti,ab,kw (Word variations have been searched) | 413 |
| #6 | anistreplase or prourokinase or retavase or rapilysin:ti,ab,kw (Word variations have been searched) | 206 |
| #7 | t‐PA or tPA:ti,ab,kw (Word variations have been searched) | 954 |
| #8 | r‐PA or rPA:ti,ab,kw (Word variations have been searched) | 53 |
| #9 | lysis:ti,ab,kw (Word variations have been searched) | 691 |
| #10 | plasminogen near/2 activator | 3004 |
| #11 | clot near/3 (bust* or break* or remov*):ti,ab,kw (Word variations have been searched) | 54 |
| #12 | thrombolysis | 2457 |
| #13 | #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 | 6691 |
| #14 | MeSH descriptor: [Arteriosclerosis] this term only | 893 |
| #15 | MeSH descriptor: [Arteriolosclerosis] this term only | 0 |
| #16 | MeSH descriptor: [Arteriosclerosis Obliterans] this term only | 71 |
| #17 | MeSH descriptor: [Atherosclerosis] this term only | 382 |
| #18 | MeSH descriptor: [Arterial Occlusive Diseases] this term only | 755 |
| #19 | MeSH descriptor: [Intermittent Claudication] this term only | 711 |
| #20 | MeSH descriptor: [Ischemia] this term only | 753 |
| #21 | MeSH descriptor: [Peripheral Vascular Diseases] explode all trees | 2150 |
| #22 | MeSH descriptor: [Vascular Diseases] this term only | 381 |
| #23 | MeSH descriptor: [Leg] explode all trees and with qualifiers: [Blood supply ‐ BS] | 1075 |
| #24 | MeSH descriptor: [Femoral Artery] explode all trees | 720 |
| #25 | MeSH descriptor: [Popliteal Artery] explode all trees | 250 |
| #26 | MeSH descriptor: [Iliac Artery] explode all trees | 151 |
| #27 | MeSH descriptor: [Tibial Arteries] explode all trees | 29 |
| #28 | (atherosclero* or arteriosclero* or PVD or PAOD or PAD) | 17195 |
| #29 | (arter*) near (*occlus* or steno* or obstuct* or lesio* or block* or obliter*) | 4872 |
| #30 | (vascular) near (*occlus* or steno* or obstuct* or lesio* or block* or obliter*) | 1378 |
| #31 | (vein*) near (*occlus* or steno* or obstuct* or lesio* or block* or obliter*) | 713 |
| #32 | (veno*) near (*occlus* or steno* or obstuct* or lesio* or block* or obliter*) | 976 |
| #33 | (peripher*) near (*occlus* or steno* or obstuct* or lesio* or block* or obliter*) | 1358 |
| #34 | (peripheral near/3 (dis* or thrombo*)) | 3349 |
| #35 | arteriopathic | 10 |
| #36 | (claudic* or hinken*) | 1436 |
| #37 | (isch* or CLI) | 16827 |
| #38 | dysvascular* | 14 |
| #39 | leg near/4 (obstruct* or occlus* or steno* or block* or obliter*) | 176 |
| #40 | limb near/4 (obstruct* or occlus* or steno* or block* or obliter*) | 228 |
| #41 | (lower near/3 extrem*) near/4 (obstruct* or occlus* or steno* or block* or obliter*) | 137 |
| #42 | (aort* or iliac or femoral or popliteal or femoro* or fempop* or crural) near/3 (obstruct* or occlus*) | 326 |
| #43 | ((bypass or graft) near/3 (*occlus* or steno* or restenos* or obstuct* or lesio* or block* or obliter*)) | 887 |
| #44 | #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30 or #31 or #32 or #33 or #34 or #35 or #36 or #37 or #38 or #39 or #40 or #41 or #42 or #43 | 39771 |
| #45 | #13 and #44 in Trials | 1996 |
Study flow diagram.
Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
Comparison 1 Intra‐arterial streptokinase versus intravenous rt‐PA, Outcome 1 Vessel Patency immediately post lysis.
Comparison 1 Intra‐arterial streptokinase versus intravenous rt‐PA, Outcome 2 Asymptomatic Limb salvage at 30 days.
Comparison 1 Intra‐arterial streptokinase versus intravenous rt‐PA, Outcome 3 Amputation at 30 days.
Comparison 1 Intra‐arterial streptokinase versus intravenous rt‐PA, Outcome 4 Death.
Comparison 1 Intra‐arterial streptokinase versus intravenous rt‐PA, Outcome 5 Complications‐ major haemorrhage.
Comparison 1 Intra‐arterial streptokinase versus intravenous rt‐PA, Outcome 6 Complications‐ minor haemorrhage.
Comparison 2 Intra‐arterial streptokinase versus intra‐arterial rt‐PA, Outcome 1 Vessel patency immediately post lysis.
Comparison 2 Intra‐arterial streptokinase versus intra‐arterial rt‐PA, Outcome 2 Asymptomatic Limb salvage at 30 days.
Comparison 2 Intra‐arterial streptokinase versus intra‐arterial rt‐PA, Outcome 3 Amputation at 30 days.
Comparison 2 Intra‐arterial streptokinase versus intra‐arterial rt‐PA, Outcome 4 Death.
Comparison 2 Intra‐arterial streptokinase versus intra‐arterial rt‐PA, Outcome 5 Complications‐ major haemorrhage.
Comparison 2 Intra‐arterial streptokinase versus intra‐arterial rt‐PA, Outcome 6 Complications‐ minor haemorrhage.
Comparison 3 Intra‐arterial urokinase versus intra‐arterial rt‐PA, Outcome 1 Vessel patency immediately post lysis.
Comparison 3 Intra‐arterial urokinase versus intra‐arterial rt‐PA, Outcome 2 Limb salvage.
Comparison 3 Intra‐arterial urokinase versus intra‐arterial rt‐PA, Outcome 3 Major amputation at 30 days‐6 months.
Comparison 3 Intra‐arterial urokinase versus intra‐arterial rt‐PA, Outcome 4 Death.
Comparison 3 Intra‐arterial urokinase versus intra‐arterial rt‐PA, Outcome 5 Complications ‐ major haemorrhage.
Comparison 3 Intra‐arterial urokinase versus intra‐arterial rt‐PA, Outcome 6 Complications ‐ minor haemorrhage.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Vessel Patency immediately post lysis Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 2 Asymptomatic Limb salvage at 30 days Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 3 Amputation at 30 days Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 4 Death Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 5 Complications‐ major haemorrhage Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 6 Complications‐ minor haemorrhage Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Vessel patency immediately post lysis Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 2 Asymptomatic Limb salvage at 30 days Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 3 Amputation at 30 days Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 4 Death Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 5 Complications‐ major haemorrhage Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 6 Complications‐ minor haemorrhage Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Vessel patency immediately post lysis Show forest plot | 3 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 2 Limb salvage Show forest plot | 3 | 368 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.68 [0.68, 4.15] |
| 3 Major amputation at 30 days‐6 months Show forest plot | 3 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 4 Death Show forest plot | 3 | 368 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.24, 2.54] |
| 5 Complications ‐ major haemorrhage Show forest plot | 3 | 298 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.68 [0.19, 2.40] |
| 6 Complications ‐ minor haemorrhage Show forest plot | 3 | 386 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.50 [0.20, 1.26] |
