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Cochrane Database of Systematic Reviews

Bloqueadores de los canales de calcio para la lesión cerebral traumática aguda

Información

DOI:
https://doi.org/10.1002/14651858.CD000565Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 20 octubre 2003see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Lesiones

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Julia Langham

    Correspondencia a: HSRU, London School of Hygiene & Tropical Medicine, London, UK

    [email protected]

  • Caroline Goldfrad

    Intensive Care National Audit and Research Centre, London, UK

  • Graham Teasdale

    Department of Neurosurgery, The Southern General Hospital, Glasgow, UK

  • Donald Shaw

    Walton Centre for Neurology & Neurosurgery, Liverpool, UK

  • Kathy Rowan

    Intensive Care National Audit and Research Centre, London, UK

Contributions of authors

JL contributed to the design of the protocol, searched for trials, extracted and entered data, contacted authors and wrote the paper. CG contributed to protocol design, extracted data, gave statistical advice and helped to write the paper. GT contributed to the design of the protocol, contacted authors of included trials and gave clinical input. KR contributed to the design of the protocol, attended steering group meetings and helped to write the paper. DS attended steering group meetings, commented on the design of the protocol and the paper.

Sources of support

Internal sources

  • Intensive Care National Audit & Research Centre, UK.

External sources

  • No sources of support supplied

Declarations of interest

The individual views of members of the Steering Group regarding the clinical effectiveness and safety of calcium channel blockers, together with any possible conflicts of interest, were recorded at the first Steering Group meeting before the start of the review.

Professor Teasdale, the principal investigator of study and a participant in study, believed that calcium channel blockers were clinically effective in patients with tSAH but was not sure how clinically effective and felt that they were less useful, if at all useful, in patients with acute traumatic brain injury.

Mr Shaw believed that calcium channel blockers were clinically effective in patients with spontaneous subarachnoid haemorrhage and that there would probably be no effect in head‐injured patients. However, there was a possibility that they might be of some benefit in the subgroup of patients with tSAH.

Both Professor Teasdale and Mr Shaw have received funding from Bayer Pharmaceutical company, one of the producers of calcium channel blockers. Both stated that there was no conflict of interest regarding the outcome of the review.

Dr Alderson, Dr Basnett, Professor Black, Miss Goldfrad, Ms Langham and Dr Rowan had no prior knowledge of the use of calcium channel blockers and therefore had no prior views that might bias the review.

Acknowledgements

Members of the Steering Group for the review:

  • Phil Alderson − Deputy Director, UK Cochrane Centre, Oxford, UK;

  • Ian Basnett − Consultant in Public Health Medicine, Camden and Islington Health Authority, London, UK;

  • Nick Black − Professor of Health Services Research, London School of Hygiene & Tropical Medicine, London, UK.

Version history

Published

Title

Stage

Authors

Version

2003 Oct 20

Calcium channel blockers for acute traumatic brain injury

Review

Julia Langham, Caroline Goldfrad, Graham Teasdale, Donald Shaw, Kathy Rowan

https://doi.org/10.1002/14651858.CD000565