Magnesium sulphate versus phenytoin for eclampsia

Lelia Duley; David J Henderson‐Smart

doi:10.1002/14651858.CD000128

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Analysis 1.1

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 1 Maternal death.

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Analysis 1.2

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 2 Recurrence of convulsions.

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Analysis 1.3

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 3 Respiratory depression.

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Analysis 1.4

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 4 Pulmonary oedema.

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Analysis 1.5

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 5 Pneumonia.

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Analysis 1.6

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 6 Ventilation.

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Analysis 1.7

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 7 Renal failure.

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Analysis 1.8

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 8 Cerebrovascular accident.

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Analysis 1.9

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 9 Liver failure.

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Analysis 1.10

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 10 Cardiac arrest.

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Analysis 1.11

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 11 Coagulopathy.

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Analysis 1.12

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 12 Admission to intensive care unit.

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Analysis 1.15

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 15 Caesarean section.

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Analysis 1.16

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 16 Labour > 8 hours.

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Analysis 1.18

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 18 Blood loss at delivery > 500 ml.

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Analysis 1.20

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 20 Mortality for the fetus or infant.

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Analysis 1.21

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 21 Apgar scores.

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Analysis 1.22

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 22 Utilization of special care baby unit (SCBU).

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Analysis 1.23

Comparison 1 Magnesium sulphate versus phenytoin, Outcome 23 Death or in SCBU > 7 days.

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Comparison 1. Magnesium sulphate versus phenytoin

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal death Show forest plot	2	797	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.24, 1.05]

2 Recurrence of convulsions Show forest plot	5	895	Risk Ratio (M‐H, Fixed, 95% CI)	0.31 [0.20, 0.47]

3 Respiratory depression Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.46, 1.09]

4 Pulmonary oedema Show forest plot	2	825	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.47, 2.10]

5 Pneumonia Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	0.44 [0.24, 0.79]

6 Ventilation Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.49, 0.90]

7 Renal failure Show forest plot	2	825	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [0.94, 2.32]

8 Cerebrovascular accident Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.20, 1.46]

9 Liver failure Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	1.50 [0.54, 4.16]

10 Cardiac arrest Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.39, 3.43]

11 Coagulopathy Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.66, 1.16]

12 Admission to intensive care unit Show forest plot	1	775	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.50, 0.89]

15 Caesarean section Show forest plot	2	650	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.86, 1.03]

16 Labour > 8 hours Show forest plot	1	628	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.85, 1.67]

18 Blood loss at delivery > 500 ml Show forest plot	1	628	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.74, 1.30]

20 Mortality for the fetus or infant Show forest plot	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

20.1 Stillbirth	2	665	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.61, 1.13]
20.2 Perinatal death	2	665	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.67, 1.09]
20.3 Neonatal death	2	665	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.59, 1.53]
21 Apgar scores Show forest plot	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

21.1 Apgar < 7 at 1 minute	1	518	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.66, 0.93]
21.2 Apgar < 7 at 5 minutes	1	518	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.52, 1.43]
22 Utilization of special care baby unit (SCBU) Show forest plot	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

22.1 Admission to SCBU	1	518	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.58, 0.91]
22.3 In SCBU > 7 days	1	518	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.33, 0.86]
23 Death or in SCBU > 7 days Show forest plot	1	643	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.63, 0.95]

Comparison 1. Magnesium sulphate versus phenytoin

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