Magnesium sulphate versus diazepam for eclampsia

Lelia Duley; David J Henderson‐Smart

doi:10.1002/14651858.CD000127

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Analysis 1.1

Comparison 1 Magnesium sulphate versus diazepam, Outcome 1 Maternal death.

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Analysis 1.2

Comparison 1 Magnesium sulphate versus diazepam, Outcome 2 Recurrence of convulsions.

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Analysis 1.3

Comparison 1 Magnesium sulphate versus diazepam, Outcome 3 Respiratory depression.

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Analysis 1.4

Comparison 1 Magnesium sulphate versus diazepam, Outcome 4 Pulmonary oedema.

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Analysis 1.5

Comparison 1 Magnesium sulphate versus diazepam, Outcome 5 Pneumonia.

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Analysis 1.6

Comparison 1 Magnesium sulphate versus diazepam, Outcome 6 Ventilation.

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Analysis 1.7

Comparison 1 Magnesium sulphate versus diazepam, Outcome 7 Renal failure.

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Analysis 1.8

Comparison 1 Magnesium sulphate versus diazepam, Outcome 8 Cerebrovascular accident (stroke).

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Analysis 1.9

Comparison 1 Magnesium sulphate versus diazepam, Outcome 9 Liver failure.

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Analysis 1.10

Comparison 1 Magnesium sulphate versus diazepam, Outcome 10 Cardiac arrest.

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Analysis 1.11

Comparison 1 Magnesium sulphate versus diazepam, Outcome 11 Coagulopathy.

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Analysis 1.12

Comparison 1 Magnesium sulphate versus diazepam, Outcome 12 Woman admitted to intensive care unit.

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Analysis 1.15

Comparison 1 Magnesium sulphate versus diazepam, Outcome 15 Caesarean section.

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Analysis 1.17

Comparison 1 Magnesium sulphate versus diazepam, Outcome 17 Labour > 8 hours.

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Analysis 1.18

Comparison 1 Magnesium sulphate versus diazepam, Outcome 18 Blood loss at delivery > 500 ml.

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Analysis 1.19

Comparison 1 Magnesium sulphate versus diazepam, Outcome 19 Death of the fetus or infant.

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Analysis 1.21

Comparison 1 Magnesium sulphate versus diazepam, Outcome 21 Apgar scores.

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Analysis 1.22

Comparison 1 Magnesium sulphate versus diazepam, Outcome 22 Utilization of special care baby unit (SCBU).

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Analysis 1.23

Comparison 1 Magnesium sulphate versus diazepam, Outcome 23 Death or in SCBU > 7 days.

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Analysis 1.24

Comparison 1 Magnesium sulphate versus diazepam, Outcome 24 Intubation at place of birth.

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Comparison 1. Magnesium sulphate versus diazepam

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal death Show forest plot	6	1336	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.37, 0.94]

2 Recurrence of convulsions Show forest plot	7	1441	Risk Ratio (M‐H, Fixed, 95% CI)	0.44 [0.34, 0.57]

3 Respiratory depression Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.57, 1.30]

4 Pulmonary oedema Show forest plot	2	974	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.39, 2.55]

5 Pneumonia Show forest plot	4	1125	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.31, 1.33]

6 Ventilation Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.45, 1.18]

7 Renal failure Show forest plot	4	1125	Risk Ratio (M‐H, Fixed, 95% CI)	0.87 [0.54, 1.39]

8 Cerebrovascular accident (stroke) Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.33, 1.23]

9 Liver failure Show forest plot	2	974	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.48, 2.07]

10 Cardiac arrest Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.47, 1.88]

11 Coagulopathy Show forest plot	4	1036	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.56, 1.41]

12 Woman admitted to intensive care unit Show forest plot	2	974	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.60, 1.08]

15 Caesarean section Show forest plot	4	734	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.96, 1.18]

17 Labour > 8 hours Show forest plot	1	633	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.82, 1.60]

18 Blood loss at delivery > 500 ml Show forest plot	2	672	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.70, 1.21]

19 Death of the fetus or infant Show forest plot	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

19.1 Stillbirth	4	756	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.63, 1.26]
19.2 Perinatal death	3	745	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.80, 1.36]
19.3 Neonatal death	3	716	Risk Ratio (M‐H, Fixed, 95% CI)	1.34 [0.84, 2.14]
21 Apgar scores Show forest plot	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

21.1 Apgar < 7 at 1 minute	2	597	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.65, 0.87]
21.2 Apgar < 7 at 5 minutes	2	597	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.55, 0.94]
22 Utilization of special care baby unit (SCBU) Show forest plot	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

22.1 Admission to SCBU	3	631	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.78, 1.04]
22.3 Stay in SCBU > 7 days	3	631	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.46, 0.95]
23 Death or in SCBU > 7 days Show forest plot	2	688	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.77, 1.16]

24 Intubation at place of birth Show forest plot	2	591	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.45, 1.00]

Comparison 1. Magnesium sulphate versus diazepam

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