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Cochrane Database of Systematic Reviews

Fenoldopam for preventing and treating acute kidney injury

Information

DOI:
https://doi.org/10.1002/14651858.CD012905Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 24 December 2017see what's new
Type:
  1. Intervention
Stage:
  1. Protocol
Cochrane Editorial Group:
  1. Cochrane Kidney and Transplant Group

Copyright:
  1. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Christopher I Esezobor

    Correspondence to: Department of Paediatrics, College of Medicine, University of Lagos, Lagos, Nigeria

    [email protected]

  • Girish C Bhatt

    Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhopal, India

  • Emmanuel E Effa

    Internal Medicine, College of Medical Sciences, University of Calabar, Calabar, Nigeria

  • Elisabeth M Hodson

    Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia

Contributions of authors

  1. Draft the protocol: CIE, GCB, EE, EH

  2. Study selection: CIE, GCB

  3. Extract data from studies: CIE, GCB

  4. Enter data into RevMan: CIE, GCB

  5. Carry out the analysis: CIE,GCB

  6. Interpret the analysis: CIE, GCB, EE, EH

  7. Draft the final review: CIE, GCB

  8. Disagreement resolution: EH

  9. Update the review: CIE, GCB

Sources of support

Internal sources

  • College of Medicine of the University of Lagos, Nigeria.

    Provision of necessary infrastructure support during the preparation of this protocol.

  • All India Institute of Medical Sciences, Bhopal, India.

    Provision of necessary infrastructure support during the preparation of this protocol.

External sources

  • No sources of support supplied

Declarations of interest

  • CIE: none known

  • GCB: Dr Girish C Bhatt has received Indian Council of Medical Research (ICMR) international fellowship (IF) as young scientist for the year 2017‐18 in division of Pediatric Nephrology at Montreal's Children Hospital, Canada.

  • EE: none known

  • EH: none known

Acknowledgements

We wish to thank the referees for their comments and feedback during the preparation of this protocol.

Version history

Published

Title

Stage

Authors

Version

2017 Dec 24

Fenoldopam for preventing and treating acute kidney injury

Protocol

Christopher I Esezobor, Girish C Bhatt, Emmanuel E Effa, Elisabeth M Hodson

https://doi.org/10.1002/14651858.CD012905

Table 1. Consensus definitions of acute kidney injury

RIFLE classification

AKIN classification

KDIGO classification

Class

GFR/serum creatinine

Urine output

Stage

Serum creatinine

Urine output

Stage

Serum creatinine

Urine output

Risk

↑ SCr ≥ 1.5 OR ↓ GFR ≥ 25%

< 0.5 mL/kg/h for 6 h

1

↑ SCr ≥ 26.5 μmol/L OR ↑SCr ≥ 150% to 200% from baseline

< 0.5 mL/kg/h for > 6 h

1

↑SCr to ≥ 1.5 to 1.9 times baseline OR ≥ 26.5 mmol/L increase

≤ 0.5 mL/kg/h for 6 to 12 h

Injury

↑ SCr ≥2 OR ↓ GFR ≥50%

< 0.5 mL/kg/h for 12 h

2

↑ SCr > 200% to 300% from baseline

< 0.5 mL/kg/h for > 6 h

2

↑SCr to 2.0 to 2.9 times baseline

0.5 mL/kg/h for ≥ 12 h

Failure

↑ SCr ≥ 3 OR ↓ GFR ≥ 75% OR if baseline SCr ≥ 353.6 μmol/L ↑ SCr > 44.2 μmol/L

< 0.3 mL/kg/h for 24 h OR anuria for 12 h

3

↑ SCr > 300% (> 3 fold) from baseline or if baseline SCr ≥ 353.6 μmol/L ↑SCr ≥ 44.2 μmol/L; also includes patients requiring RRT independent of stage

< 0.3 mL/kg/h for 24 h OR anuria for 12 h

3

↑SCr to 3.0 times baseline OR ↑ SCr to ≥ 353.6 mmol/L OR Initiation of RRT OR In patients ≤ 18 years, ↓ eGFR to ≤ 35 mL/min/1.73 m2

< 0.3 mL/kg/h for ≥ 24 OR anuria for ≥ 12 h

Loss

Complete loss of kidney function > 4 weeks

‐‐

‐‐

‐‐

‐‐

‐‐

‐‐

‐‐

ESKD

Complete loss of kidney function > 3 months

‐‐

‐‐

‐‐

‐‐

‐‐

‐‐

‐‐

ESKD ‐ end‐stage kidney disease; (e)GFR ‐ (estimated) glomerular filtration rate; SCr ‐ serum creatinine

Figures and Tables -
Table 1. Consensus definitions of acute kidney injury