Scolaris Content Display Scolaris Content Display

Cochrane Database of Systematic Reviews

Protease activity as a prognostic factor for wound healing in venous leg ulcers

This is not the most recent version

Information

DOI:
https://doi.org/10.1002/14651858.CD012841Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 30 October 2017see what's new
Type:
  1. Prognosis
Stage:
  1. Protocol
Cochrane Editorial Group:
  1. Cochrane Wounds Group

Copyright:
  1. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Article metrics

Altmetric:

Cited by:

Cited 0 times via Crossref Cited-by Linking

Collapse

Authors

  • Maggie J Westby

    Correspondence to: Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

    [email protected]

  • Jo C Dumville

    Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

  • Nikki Stubbs

    Wound Prevention and Management Service, Leeds Community Healthcare NHS Trust, St Mary's Hospital, Leeds, UK

  • Gill Norman

    Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

  • Jason KF Wong

    Plastic and Reconstructive Surgery, University Hospital South Manchester, Manchester, UK

  • Nicky Cullum

    Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

  • Richard Riley

    Research Institute for Primary Care and Health Sciences, Keele University, Keele, UK

Contributions of authors

Maggie Westby: developed the protocol; coordinated the protocol development; produced the first draft of the protocol; contributed to writing or editing the protocol; made an intellectual contribution to the protocol; approved the final version of the protocol prior to submission; and is guarantor of the protocol.

Jo Dumville: conceived the review question; developed the protocol; coordinated the protocol development; secured funding; contributed to writing or editing the protocol; made an intellectual contribution to the protocol; and approved the final version of the protocol prior to submission.

Nikki Stubbs: contributed to writing or editing the protocol; made an intellectual contribution to the protocol; advised on the protocol; and approved the final version of the protocol prior to submission.

Gill Norman: contributed to writing or editing the protocol; made an intellectual contribution to the protocol; and approved the final version of the protocol prior to submission.

Jason Wong: contributed to writing or editing the protocol; made an intellectual contribution to the protocol; advised on the protocol; and approved the final version of the protocol prior to submission.

Nicky Cullum: conceived the review question; developed the protocol; coordinated the protocol development; secured funding; contributed to writing or editing the protocol; made an intellectual contribution to the protocol; and approved the final version of the protocol prior to submission.

Richard Riley: contributed to writing or editing the protocol; advised on the protocol; made an intellectual contribution to the protocol; and approved the final version of the protocol prior to submission.

Contributions of the editorial base

Tanya Walsh (Editor): edited the protocol; advised on methodology, interpretation and protocol content; approved the final protocol prior to submission.

Gill Rizzello (Managing Editor): coordinated the editorial process; advised on content; edited the protocol.

Ursula Gonthier (Editorial Assistant): edited the reference section.

Sources of support

Internal sources

  • Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.

External sources

  • National Institute for Health Research (NIHR), UK.

    This project was supported by the NIHR, via Cochrane Infrastructure and Cochrane Programme Grant funding (NIHR Cochrane Programme Grant 13/89/08 – High Priority Cochrane Reviews in Wound Prevention and Treatment) to Cochrane Wounds. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the Systematic Reviews Programme, the NIHR, the NHS or the Department of Health.

  • NIHR Manchester Biomedical Research Centre (BRC), UK.

    This project was supported by Manchester BRC.

  • National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC), Greater Manchester, UK.

    Nicky Cullum and Jo Dumville's work on this project was partly funded by the NIHR CLAHRC, Greater Manchester. The funder had no role in the decision to publish, or preparation of the manuscript. However, the protocol may be considered to be affiliated to the work of the NIHR CLAHRC Greater Manchester. The views expressed herein are those of the authors and not necessarily those of the NHS, NIHR or the Department of Health.

Declarations of interest

Maggie Westby: my employment at the University of Manchester is funded by the NIHR and focuses on high priority Cochrane Reviews in the prevention and treatment of wounds.

Jo Dumville: I receive research funding from the NIHR for the production of systematic reviews focusing on high priority Cochrane Reviews in the prevention and treatment of wounds. This work was also partly funded by the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) Greater Manchester.

Nikki Stubbs: funding from pharmaceutical companies supports training and education events in the service and payments have been received by the author for non‐product‐related educational sessions. These have been unrelated to the subject matter of the systematic review and have never been in support or in pursuit of the promotion of products.

Gill Norman: my employment at the University of Manchester is funded by the NIHR and focuses on high priority Cochrane Reviews in the prevention and treatment of wounds.

Jason Wong: none known.

Nicky Cullum: receives research funding for wounds‐related research and systematic reviews from the NIHR.

Richard Riley: none known.

Acknowledgements

We are grateful to peer reviewers Anne‐Marie Glenny (Editor), Carolina Weller and Janet Yarrow for their comments and feedback. We would also like to thank Deirdre Walshe for copy editing the protocol, and Su Golder for devising the searches.

Version history

Published

Title

Stage

Authors

Version

2018 Sep 01

Protease activity as a prognostic factor for wound healing in venous leg ulcers

Review

Maggie J Westby, Jo C Dumville, Nikki Stubbs, Gill Norman, Jason KF Wong, Nicky Cullum, Richard D Riley

https://doi.org/10.1002/14651858.CD012841.pub2

2017 Oct 30

Protease activity as a prognostic factor for wound healing in venous leg ulcers

Protocol

Maggie J Westby, Jo C Dumville, Nikki Stubbs, Gill Norman, Jason KF Wong, Nicky Cullum, Richard Riley

https://doi.org/10.1002/14651858.CD012841

Keywords

MeSH

Prognostic factors for healing VLUs: person characteristics
Figures and Tables -
Figure 1

Prognostic factors for healing VLUs: person characteristics

Prognostic factors for VLU healing: wound characteristics 1
Figures and Tables -
Figure 2

Prognostic factors for VLU healing: wound characteristics 1

Prognostic factors for VLU healing: wound characteristics 2
Figures and Tables -
Figure 3

Prognostic factors for VLU healing: wound characteristics 2

Prognostic factors for VLU healing: number of ulcers
Figures and Tables -
Figure 4

Prognostic factors for VLU healing: number of ulcers

Prognostic factors for VLU healing: mobility and ankle flexion
Figures and Tables -
Figure 5

Prognostic factors for VLU healing: mobility and ankle flexion

Prognostic factors for VLU healing: bacteria and infection
Figures and Tables -
Figure 6

Prognostic factors for VLU healing: bacteria and infection