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Infliximab for maintenance of medically‐induced remission in Crohn's disease

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Background

Infliximab is a monoclonal antibody that binds and neutralises tumour necrosis factor‐alpha (TNF‐α) which is present in high levels in the blood serum, mucosa and stool of patients with Crohn's disease.

Objectives

To determine the efficacy and safety of infliximab for maintaining remission in patients with Crohn's disease.

Search methods

On 31 August, 2021 and 23 June, 2023, we searched CENTRAL, Embase, MEDLINE, ClinicalTrials.gov, and WHO ICTRP.

Selection criteria

Randomised controlled trials (RCTs) in which infliximab was compared to placebo or another active comparator for maintenance, remission, or response in patients with Crohn's disease.

Data collection and analysis

Pairs of review authors independently selected studies and conducted data extraction and risk of bias assessment. We expressed outcomes as risk ratios and mean differences with 95% confidence intervals. We assessed the certainty of the evidence using GRADE.

Our primary outcome was clinical relapse. Secondary outcomes were loss of clinical response, endoscopic relapse, and withdrawal due to serious and adverse events.

Main results

Nine RCTs with 1257 participants were included. They were conducted between 1999 and 2022; seven RCTs included biologically‐naive patients, and the remaining two included a mix of naive/not naive patients. Three studies included patients in clinical remission, five included patients with a mix of activity scores, and one study included biologic responders with active disease at baseline. All studies allowed some form of concomitant medication during their duration. One study exclusively included patients with fistulating disease. The age of the participants ranged from 18 to 69 years old.

All but one single‐centre RCT were multicentre RCTs. Four studies were funded by pharmaceutical companies, two had a mix of commercial and public funding, and two had public funding.

Infliximab is probably superior to placebo in preventing clinical relapse in patients who have mixed levels of clinical disease activity at baseline, and are not naive to biologics (56% vs 75%, RR 0.73, 95% CI 0.63 to 0.84, NNTB = 5, moderate‐certainty evidence). We cannot draw any conclusions on loss of clinical response (RR 0.59, 95% CI 0.37 to 0.96), withdrawals due to adverse events (RR 0.66, 95% CI 0.37 to 1.19), or serious adverse events (RR 0.60, 95% CI 0.36 to 1.00) because the evidence is very low certainty.

Infliximab combined with purine analogues is probably superior to purine analogues for clinical relapse (12% vs 59%, RR 0.20, 95% CI 0.10 to 0.42, NNTB = 2, moderate‐certainty evidence), for patients in remission, and who are not naive to biologics. We cannot draw any conclusions on withdrawals due to adverse events (RR 0.47, 95% CI 0.15 to 1.49), and serious adverse events (RR 1.19, 95% CI 0.54 to 2.64) because the evidence is very low certainty.

We cannot draw any conclusions about the effects of infliximab on serious adverse events compared to purine analogues (RR 0.79, 95% CI 0.37 to 1.68) for a population in remission at baseline because the evidence is very low certainty. There was no evidence available for the outcomes of clinical relapse, loss of clinical response, and withdrawal due to adverse events.

Infliximab may be equivalent to biosimilar for clinical relapse (47% vs 40% RR 1.18, 95% CI 0.82 to 1.69), and it may be slightly less effective in averting loss of clinical response (49% vs 32%, RR 1.50, 95% CI 1.01 to 2.23, low‐certainty evidence), for a population with mixed/low disease activity at baseline. Infliximab may be less effective than biosimilar in averting withdrawals due to adverse events (27% vs 0%, RR 20.73, 95% CI 2.86 to 150.33, low‐certainty evidence). Infliximab may be equivalent to biosimilar for serious adverse events (10% vs 10%, RR 0.99, 95% CI 0.39 to 2.50, low‐certainty evidence).

We cannot draw any conclusions on the effects of subcutaneous biosimilar compared with intravenous biosimilar on clinical relapse (RR 1.01, 95% CI 0.65 to 1.57), loss of clinical response (RR 0.94, 95% CI 0.70 to 1.25), and withdrawals due to adverse events (RR 0.77, 95% CI 0.30 to 1.97) for an active disease population with clinical response at baseline because the evidence is of very low certainty.

We cannot draw any conclusions on the effects of infliximab compared to adalimumab on loss of clinical response (RR 0.68, 95% CI 0.29 to 1.59), withdrawals due to adverse events (RR 0.10, 95% CI 0.01 to 0.72), serious adverse events (RR 0.09, 95% CI 0.01 to 1.54) for an active disease population with clinical response at baseline because the evidence is of very low certainty. There was no evidence available for the outcome of clinical relapse.

Authors' conclusions

Infliximab is probably more effective in preventing clinical relapse than placebo (moderate‐certainty evidence). Infliximab in combination with purine analogues is probably more effective in preventing clinical and endoscopic relapse than purine analogues alone (moderate‐certainty evidence). No conclusions can be drawn regarding prevention of loss of clinical response, occurrence of withdrawals due to adverse events, or total adverse events due to very low‐certainty evidence for both of these comparisons.

There may be little or no difference in prevention of clinical relapse, withdrawal due to adverse events or total adverse events between infliximab and a biosimilar (low‐certainty evidence). Infliximab may lead to more loss of clinical response than a biosimilar (low‐certainty evidence).

We were unable to draw meaningful conclusions about other comparisons and outcomes related to missing data or very low‐certainty evidence due to serious concerns about imprecision and risk of bias. Further research should focus on comparisons with other active therapies for maintaining remission, as well as ensuring adequate power calculations and reporting of methods.

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Infliximab for the maintenance of successful treatment in Crohn's Disease

Key messages

Infliximab is probably superior to placebo for preventing disease relapse for patients who have shown response to infliximab. It may also be superior to placebo for preventing loss of response in patients with fistulating disease. It may be similar to placebo in terms of total adverse events.

Infliximab combined with purine analogues is probably superior to purine analogues alone for preventing disease relapse, both clinically and endoscopically, for patients in remission, who have shown response to infliximab.

Infliximab may be similar to the biosimilar for preventing clinical relapse, and it may be slightly worse in preventing loss of clinical response, for patients with active disease who have shown response to infliximab. Infliximab may be worse than the biosimilar in terms of withdrawals due to adverse events. Infliximab may be similar to the biosimilar for serious and total adverse events.

What is Crohn's Disease?

Crohn's disease is a chronic (life‐long) inflammatory disease that can affect any part of the gut. Common symptoms include bloody poo, diarrhoea, stomach ache, fever, weight loss, fatigue, and others. When someone is experiencing symptoms of Crohn's, they are said to have 'active' disease and, when their symptoms are under control, they are considered 'in remission'. We don't know what exactly causes Crohn's, but it could be related to a combination of the genes, immune system malfunction, 'bad' gut bacteria, and environmental reasons. There is no known cure, but the symptoms are usually managed with drugs, such as steroids, immune system medications and, if necessary, surgery. At the turn of the century, a new type of drug called infliximab, which belongs to a drug category called biologics, became available and started being widely used for the treatment of Crohn's.

What did we want to find out?

We wanted to find out how infliximab compares to any other medical treatment, or dummy treatment (placebo), for maintaining remission or treatment response in Crohn's. We also wanted to find out how safe it is compared to other treatments.

What did we do?

We searched for randomised controlled trials (studies where participants are randomly assigned to one of two or more treatment groups, and can give us the highest standard of evidence) comparing infliximab with any other medical treatment for people with Crohn's Disease. We only included studies with adult patients. We had no restrictions in terms of sex, disease duration or previous medications used.

What did we find?

We found nine studies with 1257 participants that met our inclusion criteria.

Infliximab was compared to placebo, purine analogues (azathioprine and/or 6‐mercaptopurine), a biosimilar (a drug designed to be very similar to infliximab), and a different biologic drug called adalimumab. Infliximab was also combined with purine analogues and compared to purine analogues alone, and two different forms of the biosimilar were compared to each other.

Three studies had participants who were in remission at the beginning of the study, while the other six had participants with various degrees of active disease who had responded to previous treatment with infliximab at the beginning of the study.

Infliximab is probably superior to placebo for preventing disease relapse for patients who have shown response to infliximab. It may also be superior to placebo for preventing loss of response in patients with fistulating disease. It may be similar to placebo in terms of total adverse events.

Infliximab combined with purine analogues is probably superior to purine analogues alone for preventing disease relapse, both clinically and endoscopically, for patients in remission, who have shown response to infliximab.

Infliximab may be similar to the biosimilar for preventing clinical relapse, and it may be slightly worse in preventing loss of clinical response, for patients with active disease who have shown response to infliximab. Infliximab may be worse than the biosimilar in terms of withdrawals due to adverse events. Infliximab may be similar to the biosimilar for serious and total adverse events.

We cannot draw any conclusions about any other comparisons or effects because of the very low quality of the evidence.

What are the limitations of the evidence?

A lot of the evidence is of low and very low quality. This is because of problems with the methodology, lack of planning, limited participant numbers, and problems with the reporting of the data in the included studies.

How up to date is this review?

This review is up to date to June 2023.