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Cochrane Database of Systematic Reviews

Magnesium for skeletal muscle cramps

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Information

DOI:
https://doi.org/10.1002/14651858.CD009402.pub2Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 12 September 2012see what's new
Type:
  1. Intervention
Stage:
  1. Review
Cochrane Editorial Group:
  1. Cochrane Neuromuscular Group

Copyright:
  1. Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Scott R Garrison

    Correspondence to: Therapeutics Initiative, University of British Columbia, Vancouver, Canada

    [email protected]

  • G Michael Allan

    Department of Family Medicine, University of Alberta, Edmonton, Canada

  • Ravneet K Sekhon

    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada

  • Vijaya M Musini

    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada

  • Karim M Khan

    Centre for Hip Health and Mobility, University of British Columbia, Vancouver, Canada

Contributions of authors

Protocol Stage: Dr Garrison drafted the protocol and the other authors commented and approved the final text.

Review Stage: Dr Garrison and Dr Sekhon selected studies for inclusion. Dr Garrison and Dr Allan extracted data. Drs Garrison, Allan and Musini rated studies for bias (Dr Garrison did not participate in the rating of his own trial). Dr Garrison performed all data analysis and wrote the draft manuscript. All authors commented on and approved the final text.

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • Canadian Institutes of Health Research ‐ Doctoral Research Award in the Area of Research on Aging, Canada.

    Trainee Stipend (Dr. Garrison)

Declarations of interest

Drs Garrison and Khan are co‐authors of a RCT which was included in this review. None of the co‐authors of this review have links, financial or otherwise, to any company or special interest group that is involved in the marketing of magnesium or other cramp related therapies.

Acknowledgements

The Cochrane Neuromuscular Disease Group editorial base is supported by the MRC Centre for Neuromuscular Disease, the Motor Neurone Disease Association and the Muscular Dystrophy Campaign. Penelope M. A. Brasher, PhD, provided statistical support for this review and Shannon Long, MLIS, assisted with literature retrieval.

Version history

Published

Title

Stage

Authors

Version

2020 Sep 21

Magnesium for skeletal muscle cramps

Review

Scott R Garrison, Christina S Korownyk, Michael R Kolber, G Michael Allan, Vijaya M Musini, Ravneet K Sekhon, Nicolas Dugré

https://doi.org/10.1002/14651858.CD009402.pub3

2012 Sep 12

Magnesium for skeletal muscle cramps

Review

Scott R Garrison, G Michael Allan, Ravneet K Sekhon, Vijaya M Musini, Karim M Khan

https://doi.org/10.1002/14651858.CD009402.pub2

2011 Nov 09

Magnesium for skeletal muscle cramps

Protocol

Scott R Garrison, G Michael Allan, Ravneet K Sekhon, Vijaya M Musini, Karim M Khan

https://doi.org/10.1002/14651858.CD009402

Differences between protocol and review

Searching other resources

We ultimately carried out three additional approaches to obtaining studies for our review that we had not pre‐identified in our study protocol. As a result we added a sentence to the end of the "Searching other resources" section of the protocol which states: "We also searched the International Clinical Trials Registry Platform (WHO‐ICTRP) in an attempt to uncover unpublished trials, searched ISI Web of Science for papers citing the studies included in this review, and contacted the FDA to ask if they had any related clinical trial information in their possession."

'Summary of findings' table addition

Under the heading 'Secondary outcomes' in the study protocol we had pre‐identified our plans for a 'Summary of findings table' with several elements. Since considerably more poolable data were available for the outcome "Number of cramps per week at four weeks" (i.e. there were four poolable studies, compared to just two for the other frequency estimates) we chose to add this outcome to the 'Summary of findings' table. We did this because we believed number of cramps per week at four weeks to be the most reliable measure of cramp frequency given the greater amount of available data.

Number of subjects reporting minor adverse events

Although we wished to determine the number of subjects reporting any minor adverse events this was not possible from the trial descriptions, which typically described the occurrence of adverse events but not the number of subjects with one or more adverse events (i.e. the same patient could contribute to the reporting of multiple adverse events). As a result, our description of minor adverse events was qualitative.

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.