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Forest plot of comparison: 2 ECM versus ECT, outcome: 2.2 Stool frequency [number/day].
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Figure 1

Forest plot of comparison: 2 ECM versus ECT, outcome: 2.2 Stool frequency [number/day].

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Forest plot of comparison: 2 ECM versus ECT, outcome: 2.3 Abdominal pain [% days].
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Figure 2

Forest plot of comparison: 2 ECM versus ECT, outcome: 2.3 Abdominal pain [% days].

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Forest plot of comparison: 2 ECM versus ECT, outcome: 2.4 FFE [g/day].
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Figure 3

Forest plot of comparison: 2 ECM versus ECT, outcome: 2.4 FFE [g/day].

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Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 1 Change in weight.
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Analysis 1.1

Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 1 Change in weight.

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Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 2 Stool frequency.
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Analysis 1.2

Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 2 Stool frequency.

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Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 3 Abdominal pain.
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Analysis 1.3

Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 3 Abdominal pain.

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Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 4 FFE.
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Analysis 1.4

Comparison 1 ECM versus NECT + adjuvant cimetidine, Outcome 4 FFE.

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Comparison 2 ECM versus ECT, Outcome 1 Change in weight.
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Analysis 2.1

Comparison 2 ECM versus ECT, Outcome 1 Change in weight.

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Comparison 2 ECM versus ECT, Outcome 2 Stool frequency.
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Analysis 2.2

Comparison 2 ECM versus ECT, Outcome 2 Stool frequency.

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Comparison 2 ECM versus ECT, Outcome 3 Abdominal pain.
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Analysis 2.3

Comparison 2 ECM versus ECT, Outcome 3 Abdominal pain.

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Comparison 2 ECM versus ECT, Outcome 4 FFE.
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Analysis 2.4

Comparison 2 ECM versus ECT, Outcome 4 FFE.

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Comparison 3 ECM versus ECMM, Outcome 1 FFE.
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Analysis 3.1

Comparison 3 ECM versus ECMM, Outcome 1 FFE.

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Comparison 4 Creon® versus Pancrease®, Outcome 1 Co‐efficient of fat absorption.
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Analysis 4.1

Comparison 4 Creon® versus Pancrease®, Outcome 1 Co‐efficient of fat absorption.

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Comparison 5 ECM versus TPE, Outcome 1 FFE.
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Analysis 5.1

Comparison 5 ECM versus TPE, Outcome 1 FFE.

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Table 1. Glossary of terms

Term/abbreviation

Definition

BMI

body mass index

CF

cystic fibrosis

CFA

coefficient of fat absorption

chyme

the semi‐fluid mass of partly digested food expelled by the stomach into the duodenum

DIOS

distal intestinal obstruction syndrome

ECM

enteric coated microspheres

FFE

faecal fat excretion

hyperuricaemia

an excess of uric acid in the blood

hyperuricosuria

the presence of excessive amounts of uric acid in the urine

Ileocecum

the combined ileum (end of the small intestine) and cecum (start of the large intestine)

NECM

non‐enteric coated microspheres

PERT

pancreatic enzyme replacement therapy

PI

pancreatic insufficiency

porcine

relating to or suggesting swine (pigs)

RCT

randomised controlled trial

steatorrhoea

loss of fat in the stools
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Table 1. Glossary of terms
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Comparison 1. ECM versus NECT + adjuvant cimetidine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in weight Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Stool frequency Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Abdominal pain Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 FFE Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
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Comparison 1. ECM versus NECT + adjuvant cimetidine
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Comparison 2. ECM versus ECT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in weight Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 At 1 month

2

82

Mean Difference (IV, Fixed, 95% CI)

0.32 [‐0.03, 0.67]

2 Stool frequency Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 At 1 month

2

82

Mean Difference (IV, Fixed, 95% CI)

‐0.58 [‐0.85, ‐0.30]

3 Abdominal pain Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 At 1 month

2

82

Mean Difference (IV, Fixed, 95% CI)

‐7.96 [‐12.97, ‐2.94]

4 FFE Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 At 1 month

2

66

Mean Difference (IV, Fixed, 95% CI)

‐11.79 [‐17.42, ‐6.15]
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Comparison 2. ECM versus ECT
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Comparison 3. ECM versus ECMM

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FFE Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
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Comparison 3. ECM versus ECMM
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Comparison 4. Creon® versus Pancrease®

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Co‐efficient of fat absorption Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
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Comparison 4. Creon® versus Pancrease®
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Comparison 5. ECM versus TPE

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FFE Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figures and Tables -
Comparison 5. ECM versus TPE
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