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Forest plot of comparison: 3 Lornoxicam versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 6 hours.
Figures and Tables -
Figure 1

Forest plot of comparison: 3 Lornoxicam versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 6 hours.

Comparison 1 Lornoxicam versus placebo, Outcome 1 Participants with at least 50% pain relief over 6 hours.
Figures and Tables -
Analysis 1.1

Comparison 1 Lornoxicam versus placebo, Outcome 1 Participants with at least 50% pain relief over 6 hours.

Comparison 1 Lornoxicam versus placebo, Outcome 2 Participants with any adverse event.
Figures and Tables -
Analysis 1.2

Comparison 1 Lornoxicam versus placebo, Outcome 2 Participants with any adverse event.

Table 1. Summary of outcomes: analgesia and rescue medication

Analgesia

Rescue medication

Study ID

Treatment

PI or PR

Number with 50% PR

PGE: v good or excellent

Median time to use (h)

% using

Moller 2008

(1) Lornoxicam 8 mg SR, n = 80

(2) Lornoxicam 8 mg QR, n = 80

(3) Placebo, n = 40

TOTPAR 6:

(1) 8.1

(2) 11.3

(3) 1.8

(1) 27/80

(2) 41/80

(3) 0/40

No usable data

(1) 4.0

(2) 5.7

(3) 1.1

at 8 h:

(1) 48/80

(2) 50/80

(3) 37/40

Norholt 1995

(1) Lornoxicam 4 mg, n = 43

(2) Lornoxicam 8 mg, n = 45

(3) Lornoxicam 16 mg, n = 48

(4) Lornoxicam 32 mg, n = 48

(5) Ketorolac 10 mg, n = 46

(6) Placebo, n = 48

TOTPAR 6:

(1) 9.6

(2) 13.7

(3) 15.0

(4) 17.7

(6) 3.7

(1) 18/43

(2) 29/45

(3) 34/48

(4) 42/48

(6) 4/48

(1) 12/43

(2) 23/45

(3) 27/48

(4) 32/48

(5) 25/46

(6) 4/48

Mean:

(1) 3.1

(2) 4.1

(3) 4.9

(4) 5.1

(6) 1.7

No data

Patel 1991

(1) Lornoxicam 2 mg, n = 30

(2) Lornoxicam 4 mg, n = 30

(3) Lornoxicam 8 mg, n = 30

(4) Aspirin 650 mg, n = 30

(6) Placebo, n = 30

TOTPAR 6:

(1) 8.43

(2) 8.99

(3) 11.12

(5) 7.38

(1) 11/30

(2) 11/30

(3) 15/30

(5) 9/30

No usable data

No data

No data

QR ‐ quick release; SR ‐ slow release

Figures and Tables -
Table 1. Summary of outcomes: analgesia and rescue medication
Table 2. Summary of outcomes: adverse events and withdrawals

Adverse events

Withdrawals

Study ID

Treatment

Any

Serious

Adverse event

Other

Moller 2008

(1) Lornoxicam 8 mg SR, n = 80

(2) Lornoxicam 8 mg QR, n = 80

(3) Placebo, n = 40

at 7 days:

(1) 39/80

(2) 43/80

(3) 14/40

None

None

None

Norholt 1995

(1) Lornoxicam 4 mg, n = 43

(2) Lornoxicam 8 mg, n = 45

(3) Lornoxicam 16 mg, n = 48

(4) Lornoxicam 32 mg, n = 48

(5) Ketorolac 10 mg, n = 46

(6) Placebo, n = 48

No usable data

None reported

None

None

Patel 1991

(1) Lornoxicam 2 mg, n = 30

(2) Lornoxicam 4 mg, n = 30

(3) Lornoxicam 8 mg, n = 30

(4) Aspirin 650 mg, n = 30

(6) Placebo, n = 30

at 8 h:

(1) 3/30

(2) 1/30

(3) 2/30

(4) 2/30

(5) 2/30

None

None

None

QR ‐ quick release; SR ‐ slow release

Figures and Tables -
Table 2. Summary of outcomes: adverse events and withdrawals
Comparison 1. Lornoxicam versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 6 hours Show forest plot

3

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

1.1 Lornoxicam 4 mg

2

151

Risk Ratio (M‐H, Fixed, 95% CI)

2.35 [1.33, 4.14]

1.2 Lornoxicam 8 mg

3

273

Risk Ratio (M‐H, Fixed, 95% CI)

4.69 [2.70, 8.12]

2 Participants with any adverse event Show forest plot

2

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

2.1 Lornoxicam 2 to 8 mg

2

320

Risk Ratio (M‐H, Fixed, 95% CI)

1.41 [0.92, 2.17]

2.2 Lornoxicam 8 mg

2

260

Risk Ratio (M‐H, Fixed, 95% CI)

1.43 [0.92, 2.21]

Figures and Tables -
Comparison 1. Lornoxicam versus placebo