Scolaris Content Display Scolaris Content Display

Comparison 1 Calcium vs. placebo, Outcome 1 Calcium vs. placebo (infusion, early).
Figures and Tables -
Analysis 1.1

Comparison 1 Calcium vs. placebo, Outcome 1 Calcium vs. placebo (infusion, early).

Comparison 1 Calcium vs. placebo, Outcome 2 Calcium vs. placebo (infusion, late).
Figures and Tables -
Analysis 1.2

Comparison 1 Calcium vs. placebo, Outcome 2 Calcium vs. placebo (infusion, late).

Comparison 1 Calcium vs. placebo, Outcome 3 Calcium vs. placebo (bolus, early).
Figures and Tables -
Analysis 1.3

Comparison 1 Calcium vs. placebo, Outcome 3 Calcium vs. placebo (bolus, early).

Comparison 1 Calcium vs. placebo, Outcome 4 Calcium vs. placebo (bolus, late).
Figures and Tables -
Analysis 1.4

Comparison 1 Calcium vs. placebo, Outcome 4 Calcium vs. placebo (bolus, late).

Comparison 1 Calcium vs. placebo, Outcome 5 Calcium vs. placebo (neonates).
Figures and Tables -
Analysis 1.5

Comparison 1 Calcium vs. placebo, Outcome 5 Calcium vs. placebo (neonates).

Comparison 1 Calcium vs. placebo, Outcome 6 Calcium vs. placebo (hypocalcemia).
Figures and Tables -
Analysis 1.6

Comparison 1 Calcium vs. placebo, Outcome 6 Calcium vs. placebo (hypocalcemia).

Table 1. Methods of calcium administration and measurement of calcium concentration

Study

Indication

Method

Calcium measurement

Auffant 1981

[Ca2+]i < 0.9 mmol/L

Calcium chloride

Bolus (n=10): 5 mg/kg Infusion (n=7): 0.5 mg/kg/min

Preoperatively, during surgery, and every 15 minutes for 2 hours after beginning calcium administration

Butterworth 1992

Prophylaxis

Calcium chloride

Group 1: 1 mg/kg/min for 20 minutes followed by 0.25 mg/kg/min for 5 minutes

Group 2: 1 mg/kg/min for 20 minutes

Group 1: baseline, 25, 31, and 37 minutes after beginning calcium administration

Group 2: baseline, every 5 minutes for 20 minutes after beginning calcium adminstration

Porcelli 1995

[Ca]t < 1.75 mmol/L

Calcium gluconate

100 mg/kg infused over 30‐60 minutes

One measurement at 3‐6 hours after administration

Scott 1984

[Ca2+]i < 0.63 mmol/dL

Calcium gluconate

Bolus: 200 mg/kg every 6 hours at 100 mg/min

Infusion: 400 mg/kg/24h (˜0.278 mg/kg/min)

Every 6 hours for 24 hours after beginning calcium administration

Every 6 hours for 24 hours after beginning calcium administration

Zaloga 1990

Prophylaxis

Calcium chloride

10 mg/kg bolus followed by 2 mg/kg/h

Baseline, 10, 20, 24, 32, 36, and 44 minutes after beginning calcium administration

[Ca2+]i = ionized calcium concentration

Figures and Tables -
Table 1. Methods of calcium administration and measurement of calcium concentration
Comparison 1. Calcium vs. placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Calcium vs. placebo (infusion, early) Show forest plot

3

83

Mean Difference (IV, Random, 95% CI)

0.24 [‐0.00, 0.49]

2 Calcium vs. placebo (infusion, late) Show forest plot

3

74

Mean Difference (IV, Random, 95% CI)

0.12 [‐0.02, 0.26]

3 Calcium vs. placebo (bolus, early) Show forest plot

1

17

Mean Difference (IV, Random, 95% CI)

0.08 [0.05, 0.11]

4 Calcium vs. placebo (bolus, late) Show forest plot

2

35

Mean Difference (IV, Random, 95% CI)

0.05 [‐0.01, 0.12]

5 Calcium vs. placebo (neonates) Show forest plot

2

70

Mean Difference (IV, Random, 95% CI)

0.06 [0.01, 0.11]

6 Calcium vs. placebo (hypocalcemia) Show forest plot

3

93

Mean Difference (IV, Random, 95% CI)

0.09 [0.02, 0.16]

Figures and Tables -
Comparison 1. Calcium vs. placebo