Scolaris Content Display Scolaris Content Display

Flow diagram showing study selection
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Figure 1

Flow diagram showing study selection

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Funnel plot of comparison: 2 Secondary outcomes, outcome: 2.1 all‐cause mortality
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Figure 4

Funnel plot of comparison: 2 Secondary outcomes, outcome: 2.1 all‐cause mortality

Comparison 1 Primary outcome, Outcome 1 Cardiovascular mortality.
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Analysis 1.1

Comparison 1 Primary outcome, Outcome 1 Cardiovascular mortality.

Comparison 2 Secondary outcomes, Outcome 1 All‐cause mortality.
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Analysis 2.1

Comparison 2 Secondary outcomes, Outcome 1 All‐cause mortality.

Comparison 2 Secondary outcomes, Outcome 2 Myocardial infarction (fatal and non fatal).
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Analysis 2.2

Comparison 2 Secondary outcomes, Outcome 2 Myocardial infarction (fatal and non fatal).

Comparison 2 Secondary outcomes, Outcome 3 Coronary revascularisation.
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Analysis 2.3

Comparison 2 Secondary outcomes, Outcome 3 Coronary revascularisation.

Comparison 2 Secondary outcomes, Outcome 4 Stroke.
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Analysis 2.4

Comparison 2 Secondary outcomes, Outcome 4 Stroke.

Comparison 2 Secondary outcomes, Outcome 5 Deep venous thrombosis and pulmonary embolism.
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Analysis 2.5

Comparison 2 Secondary outcomes, Outcome 5 Deep venous thrombosis and pulmonary embolism.

Comparison 2 Secondary outcomes, Outcome 6 Thrombosis of dialysis access.
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Analysis 2.6

Comparison 2 Secondary outcomes, Outcome 6 Thrombosis of dialysis access.

Comparison 2 Secondary outcomes, Outcome 7 Adverse events.
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Analysis 2.7

Comparison 2 Secondary outcomes, Outcome 7 Adverse events.

Comparison 1. Primary outcome

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Cardiovascular mortality Show forest plot

4

1186

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.70, 1.22]

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Comparison 1. Primary outcome
Comparison 2. Secondary outcomes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 All‐cause mortality Show forest plot

6

2447

Risk Ratio (M‐H, Random, 95% CI)

1.00 [0.89, 1.11]

2 Myocardial infarction (fatal and non fatal) Show forest plot

4

1510

Risk Ratio (M‐H, Random, 95% CI)

1.04 [0.66, 1.62]

3 Coronary revascularisation Show forest plot

2

1160

Risk Ratio (M‐H, Random, 95% CI)

0.83 [0.22, 3.14]

4 Stroke Show forest plot

4

1510

Risk Ratio (M‐H, Random, 95% CI)

0.89 [0.57, 1.40]

5 Deep venous thrombosis and pulmonary embolism Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Totals not selected

6 Thrombosis of dialysis access Show forest plot

2

1261

Risk Ratio (M‐H, Random, 95% CI)

1.00 [0.88, 1.14]

7 Adverse events Show forest plot

3

1248

Risk Ratio (M‐H, Random, 95% CI)

1.12 [0.51, 2.47]

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Comparison 2. Secondary outcomes