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Comparison 1 noninvasive versus invasive weaning, Outcome 1 mortality.
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Analysis 1.1

Comparison 1 noninvasive versus invasive weaning, Outcome 1 mortality.

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Comparison 2 noninvasive versus invasive weaning, Outcome 1 weaning failure.
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Analysis 2.1

Comparison 2 noninvasive versus invasive weaning, Outcome 1 weaning failure.

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Comparison 3 noninvasive versus invasive weaning, Outcome 1 nosocomial pneumonia.
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Analysis 3.1

Comparison 3 noninvasive versus invasive weaning, Outcome 1 nosocomial pneumonia.

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Comparison 4 noninvasive versus invasive weaning, Outcome 1 LOS ICU.
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Analysis 4.1

Comparison 4 noninvasive versus invasive weaning, Outcome 1 LOS ICU.

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Comparison 5 noninvasive versus invasive weaning, Outcome 1 LOS hospital.
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Analysis 5.1

Comparison 5 noninvasive versus invasive weaning, Outcome 1 LOS hospital.

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Comparison 6 noninvasive versus invasive weaning, Outcome 1 average total duration of mechanical ventilatory support.
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Analysis 6.1

Comparison 6 noninvasive versus invasive weaning, Outcome 1 average total duration of mechanical ventilatory support.

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Comparison 7 noninvasive versus invasive weaning, Outcome 1 average duration of ventilation related to weaning.
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Analysis 7.1

Comparison 7 noninvasive versus invasive weaning, Outcome 1 average duration of ventilation related to weaning.

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Comparison 8 noninvasive versus invasive weaning, Outcome 1 duration of endotracheal mechanical ventilation.
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Analysis 8.1

Comparison 8 noninvasive versus invasive weaning, Outcome 1 duration of endotracheal mechanical ventilation.

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Comparison 9 sensitivity analysis: excluding quasi‐randomized study, Outcome 1 mortality.
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Analysis 9.1

Comparison 9 sensitivity analysis: excluding quasi‐randomized study, Outcome 1 mortality.

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Comparison 9 sensitivity analysis: excluding quasi‐randomized study, Outcome 2 nosocomial pneumonia.
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Analysis 9.2

Comparison 9 sensitivity analysis: excluding quasi‐randomized study, Outcome 2 nosocomial pneumonia.

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Table 1. Comparison of NPPV and IPPV weaning strategies on outcomes

Outcome

Number of trials

Number of patients

Test of homogeneity

Summary estimate

Significance

Mortality

5

171

p=0.83

RR 0.41 [0.22, 0.76]

p=0.005

VAP

4

150

p=0.27

RR 0.28 [0.09, 0.85]

p=0.03

Weaning failure

3

104

p=0.20

RR 0.82 [0.29, 2.32]

p=0.71

ICU LOS

3

126

p=0.05

WMD ‐6.88 [‐12.60, ‐1.15]

p=0.02

Hospital LOS

3

100

p=0.20

WMD ‐7.33 [‐14.05, ‐0.61]

p=0.03

Total duration MV

2

93

p=0.59

WMD ‐7.33 [‐11.45, ‐3.22]

p=0.0005

Duration related to weaning

3

92

p<0.00001

WMD ‐2.72 [‐15.58, 10.14)

p=0.68

Duration ETMV

3

97

p=0.08

WMD ‐6.32 [‐12.12, ‐0.52]

p=0.03
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Table 1. Comparison of NPPV and IPPV weaning strategies on outcomes
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Comparison 1. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 mortality Show forest plot

5

171

Risk Ratio (M‐H, Random, 95% CI)

0.41 [0.22, 0.76]

1.1 COPD

2

74

Risk Ratio (M‐H, Random, 95% CI)

0.25 [0.07, 0.91]

1.2 mixed

3

97

Risk Ratio (M‐H, Random, 95% CI)

0.47 [0.23, 0.96]
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Comparison 1. noninvasive versus invasive weaning
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Comparison 2. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 weaning failure Show forest plot

3

104

Risk Ratio (M‐H, Random, 95% CI)

0.82 [0.29, 2.32]

1.1 COPD

1

50

Risk Ratio (M‐H, Random, 95% CI)

0.38 [0.11, 1.25]

1.2 mixed

2

54

Risk Ratio (M‐H, Random, 95% CI)

1.28 [0.45, 3.60]
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Comparison 2. noninvasive versus invasive weaning
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Comparison 3. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 nosocomial pneumonia Show forest plot

4

150

Risk Ratio (M‐H, Random, 95% CI)

0.28 [0.09, 0.85]
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Comparison 3. noninvasive versus invasive weaning
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Comparison 4. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 LOS ICU Show forest plot

3

126

Mean Difference (IV, Random, 95% CI)

‐6.88 [‐12.60, ‐1.15]
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Comparison 4. noninvasive versus invasive weaning
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Comparison 5. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 LOS hospital Show forest plot

3

100

Mean Difference (IV, Random, 95% CI)

‐7.33 [‐14.05, ‐0.61]
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Comparison 5. noninvasive versus invasive weaning
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Comparison 6. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 average total duration of mechanical ventilatory support Show forest plot

2

93

Mean Difference (IV, Random, 95% CI)

‐7.33 [‐11.45, ‐3.22]
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Comparison 6. noninvasive versus invasive weaning
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Comparison 7. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 average duration of ventilation related to weaning Show forest plot

3

92

Mean Difference (IV, Random, 95% CI)

‐2.72 [‐15.58, 10.14]
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Comparison 7. noninvasive versus invasive weaning
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Comparison 8. noninvasive versus invasive weaning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 duration of endotracheal mechanical ventilation Show forest plot

3

97

Mean Difference (IV, Random, 95% CI)

‐6.32 [‐12.12, ‐0.52]
Figures and Tables -
Comparison 8. noninvasive versus invasive weaning
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Comparison 9. sensitivity analysis: excluding quasi‐randomized study

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 mortality Show forest plot

4

147

Risk Ratio (M‐H, Random, 95% CI)

0.43 [0.23, 0.81]

2 nosocomial pneumonia Show forest plot

3

126

Risk Ratio (M‐H, Random, 95% CI)

0.37 [0.15, 0.93]
Figures and Tables -
Comparison 9. sensitivity analysis: excluding quasi‐randomized study
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