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Sensory afferent nerve supply of the female pelvic organs. C = afferent nerve supply of cervix (illustrated on right side of diagram); O = afferent nerve supply of ovary (illustrated on left side of diagram); U = afferent nerve supply of uterus (illustrated on right side of diagram); P = parasympathetic nerve; S = sympathetic nerve. Copyright approval for reproduction of this figure has been kindly granted by Blackwell Science, publisher of Gynaecological Endoscopy (Johnson 2000).
Figures and Tables -
Figure 1

Sensory afferent nerve supply of the female pelvic organs. C = afferent nerve supply of cervix (illustrated on right side of diagram); O = afferent nerve supply of ovary (illustrated on left side of diagram); U = afferent nerve supply of uterus (illustrated on right side of diagram); P = parasympathetic nerve; S = sympathetic nerve. Copyright approval for reproduction of this figure has been kindly granted by Blackwell Science, publisher of Gynaecological Endoscopy (Johnson 2000).

Comparison 1 LUNA versus control, Outcome 1 Pain relief ‐ up to 6 months.
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Analysis 1.1

Comparison 1 LUNA versus control, Outcome 1 Pain relief ‐ up to 6 months.

Comparison 1 LUNA versus control, Outcome 2 Pain relief ‐ up to 12 months.
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Analysis 1.2

Comparison 1 LUNA versus control, Outcome 2 Pain relief ‐ up to 12 months.

Comparison 1 LUNA versus control, Outcome 4 Pain relief up to 36 months.
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Analysis 1.4

Comparison 1 LUNA versus control, Outcome 4 Pain relief up to 36 months.

Comparison 2 PSN versus control, Outcome 1 Pain relief ‐ up to 6 months.
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Analysis 2.1

Comparison 2 PSN versus control, Outcome 1 Pain relief ‐ up to 6 months.

Comparison 2 PSN versus control, Outcome 2 Pain relief ‐ up to 12 months.
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Analysis 2.2

Comparison 2 PSN versus control, Outcome 2 Pain relief ‐ up to 12 months.

Comparison 2 PSN versus control, Outcome 3 Adverse effects.
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Analysis 2.3

Comparison 2 PSN versus control, Outcome 3 Adverse effects.

Comparison 3 LUNA versus LPSN, Outcome 1 Pain relief ‐ up to 6 months.
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Analysis 3.1

Comparison 3 LUNA versus LPSN, Outcome 1 Pain relief ‐ up to 6 months.

Comparison 3 LUNA versus LPSN, Outcome 2 Pain relief ‐ up to 12 months.
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Analysis 3.2

Comparison 3 LUNA versus LPSN, Outcome 2 Pain relief ‐ up to 12 months.

Comparison 3 LUNA versus LPSN, Outcome 3 Adverse effects.
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Analysis 3.3

Comparison 3 LUNA versus LPSN, Outcome 3 Adverse effects.

Comparison 1. LUNA versus control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain relief ‐ up to 6 months Show forest plot

4

258

Odds Ratio (M‐H, Fixed, 95% CI)

1.15 [0.66, 1.99]

1.1 Primary dysmenorrhoea

2

68

Odds Ratio (M‐H, Fixed, 95% CI)

1.43 [0.56, 3.69]

1.2 Secondary dysmenorrhoea

3

190

Odds Ratio (M‐H, Fixed, 95% CI)

1.03 [0.52, 2.02]

2 Pain relief ‐ up to 12 months Show forest plot

3

285

Odds Ratio (M‐H, Fixed, 95% CI)

1.20 [0.72, 1.99]

2.1 Primary dysmenorrhoea

2

68

Odds Ratio (M‐H, Fixed, 95% CI)

6.12 [1.78, 21.03]

2.2 Secondary dysmenorrhoea

2

217

Odds Ratio (M‐H, Fixed, 95% CI)

0.77 [0.43, 1.39]

4 Pain relief up to 36 months Show forest plot

1

116

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.84 [0.39, 1.80]

4.2 Secondary dysmenorrhoea

1

116

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.84 [0.39, 1.80]

Figures and Tables -
Comparison 1. LUNA versus control
Comparison 2. PSN versus control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain relief ‐ up to 6 months Show forest plot

1

126

Odds Ratio (M‐H, Fixed, 95% CI)

4.52 [1.84, 11.09]

1.2 PSN with surgical treatment of endometriosis vs surgical treatment of endometriosis only

1

126

Odds Ratio (M‐H, Fixed, 95% CI)

4.52 [1.84, 11.09]

2 Pain relief ‐ up to 12 months Show forest plot

2

197

Odds Ratio (M‐H, Fixed, 95% CI)

3.14 [1.59, 6.21]

2.2 PSN with surgical treatment of endometriosis vs surgical treatment of endometriosis only

2

197

Odds Ratio (M‐H, Fixed, 95% CI)

3.14 [1.59, 6.21]

3 Adverse effects Show forest plot

1

71

Peto Odds Ratio (Peto, Fixed, 95% CI)

14.57 [5.04, 42.15]

3.2 PSN with surgical treatment of endometriosis vs surgical treatment of endometriosis only

1

71

Peto Odds Ratio (Peto, Fixed, 95% CI)

14.57 [5.04, 42.15]

Figures and Tables -
Comparison 2. PSN versus control
Comparison 3. LUNA versus LPSN

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain relief ‐ up to 6 months Show forest plot

1

68

Odds Ratio (M‐H, Fixed, 95% CI)

0.67 [0.17, 2.61]

1.1 Primary dysmenorrhoea

1

68

Odds Ratio (M‐H, Fixed, 95% CI)

0.67 [0.17, 2.61]

2 Pain relief ‐ up to 12 months Show forest plot

1

68

Odds Ratio (M‐H, Fixed, 95% CI)

0.10 [0.03, 0.32]

2.1 Primary dysmenorrhoea

1

68

Odds Ratio (M‐H, Fixed, 95% CI)

0.10 [0.03, 0.32]

3 Adverse effects Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3.3 Primary dysmenorrhoea

1

68

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.02 [0.01, 0.06]

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Comparison 3. LUNA versus LPSN