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Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 1: Vertigo ‐ number of attacks per month at baseline

Figures and Tables -
Analysis 1.1

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 1: Vertigo ‐ number of attacks per month at baseline

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 2: Vertigo ‐ number of attacks per month at 15 days

Figures and Tables -
Analysis 1.2

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 2: Vertigo ‐ number of attacks per month at 15 days

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 3: Vertigo ‐ number of attacks per month at 1 month

Figures and Tables -
Analysis 1.3

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 3: Vertigo ‐ number of attacks per month at 1 month

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 4: Vertigo ‐ number of attacks per month at 2 months

Figures and Tables -
Analysis 1.4

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 4: Vertigo ‐ number of attacks per month at 2 months

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 5: Vertigo ‐ number of attacks per month at 3 months

Figures and Tables -
Analysis 1.5

Comparison 1: Betahistine versus placebo ‐ number of vertigo attacks, Outcome 5: Vertigo ‐ number of attacks per month at 3 months

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 1: Vertigo intensity scores at baseline

Figures and Tables -
Analysis 2.1

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 1: Vertigo intensity scores at baseline

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 2: Vertigo intensity scores at 15 days

Figures and Tables -
Analysis 2.2

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 2: Vertigo intensity scores at 15 days

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 3: Vertigo intensity scores at 1 month

Figures and Tables -
Analysis 2.3

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 3: Vertigo intensity scores at 1 month

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 4: Vertigo intensity scores at 2 months

Figures and Tables -
Analysis 2.4

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 4: Vertigo intensity scores at 2 months

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 5: Vertigo intensity scores at 3 months

Figures and Tables -
Analysis 2.5

Comparison 2: Betahistine versus placebo ‐ vertigo intensity scores, Outcome 5: Vertigo intensity scores at 3 months

Table 1. Quality of included studies

OVERALL GRADE

STUDY

YEAR

DIAGNOSTIC ACCURACY

OUTCOME QUALITY

RISK OF BIAS

A

None

B

Schmidt

1992

II

I / III

Medium

C

Burkin

1967

III

III

Medium

C

Okamato

1968

III

I / II

Low

C

Elia

1970

III

I / II

Low

C

Salami

1984

III

I

Medium

C

Ricci

1987

III

I

Medium

C

Mira

2003

III

II

Medium

Figures and Tables -
Table 1. Quality of included studies
Comparison 1. Betahistine versus placebo ‐ number of vertigo attacks

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1.1 Vertigo ‐ number of attacks per month at baseline Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

1.16 [‐2.78, 5.10]

1.2 Vertigo ‐ number of attacks per month at 15 days Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐2.32 [‐4.10, ‐0.54]

1.3 Vertigo ‐ number of attacks per month at 1 month Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐2.37 [‐3.94, ‐0.80]

1.4 Vertigo ‐ number of attacks per month at 2 months Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐2.27 [‐4.40, ‐0.14]

1.5 Vertigo ‐ number of attacks per month at 3 months Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐2.74 [‐4.87, ‐0.61]

Figures and Tables -
Comparison 1. Betahistine versus placebo ‐ number of vertigo attacks
Comparison 2. Betahistine versus placebo ‐ vertigo intensity scores

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

2.1 Vertigo intensity scores at baseline Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

0.06 [‐0.36, 0.48]

2.2 Vertigo intensity scores at 15 days Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐0.16 [‐0.51, 0.19]

2.3 Vertigo intensity scores at 1 month Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐0.36 [‐0.71, ‐0.01]

2.4 Vertigo intensity scores at 2 months Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐0.53 [‐0.93, ‐0.13]

2.5 Vertigo intensity scores at 3 months Show forest plot

1

72

Mean Difference (IV, Fixed, 95% CI)

‐0.55 [‐0.92, ‐0.18]

Figures and Tables -
Comparison 2. Betahistine versus placebo ‐ vertigo intensity scores