Appendix 1. MEDLINE search strategy

1 "attention deficit and disruptive behavior disorders"/
2 attention deficit disorder with hyperactivity/
3 conduct disorder/
4 ADHD.tw,kf.
5 ADDH.tw,kf.
6 ADHS.tw,kf.
7 ("AD/HD" or HKD).tw,kf.
8 TDAH.tw,kf.
9 ((attention$ or behav$) adj3 (defic$ or dysfunc$ or disorder$)).tw,kf.
10 ((disrupt$ adj3 disorder$) or (disrupt$ adj3 behav$) or (defian$ adj3 disorder$) or (defian$ adj3 behav$)).tw,kf.
11 (impulsiv$ or inattentiv$ or inattention$).tw,kf.
12 hyperkinesis/
13 (hyperkin$ or hyper‐kin$).tw,kf.
14 (minimal adj3 brain adj3 (disorder$ or dysfunct$ or damage$)).tw,kf.
15 (hyperactiv$ or hyper‐activ$).tw,kf.
16 or/1‐15
17 Adrenergic Uptake Inhibitors/
18 Antidepressive Agents, Second‐Generation/
19 selective noradrenaline re‐uptake inhibitor$.mp.
20 SNR$1.mp.
21 Atomoxetine Hydrochloride/
22 Atomoxetin$.mp.
23 Strattera.mp.
24 Morpholines/
25 Reboxetine.mp.
26 Edronax.mp.
27 Vestra.mp.
28 Maprotiline/
29 Maprotiline.mp.
30 Ludiomil.mp.
31 noradrenaline re‐uptake inhibitor$.mp.
32 noradrenaline reuptake inhibitor$.mp.
33 norepinephrine re‐uptake inhibitor$.mp.
34 norepinephrine reuptake inhibitor$.mp.
35 NARI$1.tw,kf.
36 NRI$1.tw,kf.
37 Viloxazine/
38 Viloxazine.mp.
39 Vivalan.mp.
40 or/17‐39
41 randomized controlled trial.pt.
42 controlled clinical trial.pt.
43 randomi#ed.ab.
44 placebo$.ab.
45 drug therapy.fs.
46 randomly.ab.
47 trial.ab.
48 groups.ab.
49 or/41‐48
50 exp animals/ not humans.sh.
51 49 not 50
52 16 and 40 and 51